PF 240570PCT CN PCT/CN2023/109110 2023-07-25 JW THERAPEUTICS R&D (SHANGHAI) CO., LTD. FUSION PROTEIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CD20 43 247 AA PAT source 1..247 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTV 249 AA PAT source 1..249 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSGGGGSGGGGSGGGGSDIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTV 242 AA PAT source 1..242 mol_type protein organism synthetic construct QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSGGGGSGGGGSGGGGSQIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKR 122 AA PAT source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSS 110 AA PAT source 1..110 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTV 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYAMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct TISWNSGSIGYADSVKG 13 AA PAT source 1..13 mol_type protein organism synthetic construct DIQYGNYYYGMDV 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein organism synthetic construct DASNRAT 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQRSNWPIT 119 AA PAT source 1..119 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct DIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTV 5 AA PAT source 1..5 mol_type protein organism synthetic construct YSWIN 17 AA PAT source 1..17 mol_type protein organism synthetic construct RIFPGDGDTDYNGKFKG 10 AA PAT source 1..10 mol_type protein organism synthetic construct NVFDGYWLVY 16 AA PAT source 1..16 mol_type protein organism synthetic construct RSSKSLLHSNGITYLY 7 AA PAT source 1..7 mol_type protein organism synthetic construct QMSNLVS 9 AA PAT source 1..9 mol_type protein organism synthetic construct AQNLELPYT 120 AA PAT source 1..120 mol_type protein organism synthetic construct QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVS 107 AA PAT source 1..107 mol_type protein organism synthetic construct QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKR 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYNMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct AIYPGNGDTSYNQKFKG 12 AA PAT source 1..12 mol_type protein organism synthetic construct STYYGGDWYFNV 10 AA PAT source 1..10 mol_type protein organism synthetic construct RASSSVSYIH 7 AA PAT source 1..7 mol_type protein organism synthetic construct ATSNLAS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQWTSNPPT 15 AA PAT source 1..15 mol_type protein organism synthetic construct GGGGSGGGGSGGGGS 38 AA PAT source 1..38 mol_type protein organism synthetic construct PPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFACD 40 AA PAT source 1..40 mol_type protein organism synthetic construct KIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKP 12 AA PAT source 1..12 mol_type protein organism synthetic construct ESKYGPPCPPCP 24 AA PAT source 1..24 mol_type protein organism synthetic construct IYIWAPLAGTCGVLLLSLVITLYC 28 AA PAT source 1..28 mol_type protein organism synthetic construct MFWVLVVVGGVLACYSLLVTVAFIIFWV 42 AA PAT source 1..42 mol_type protein organism synthetic construct KRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 112 AA PAT source 1..112 mol_type protein organism synthetic construct RVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 469 AA PAT source 1..469 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTVKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPMFWVLVVVGGVLACYSLLVTVAFIIFWVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 443 AA PAT source 1..443 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGYAFSYSWINWVRQAPGQGLEWMGRIFPGDGDTDYNGKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARNVFDGYWLVYWGQGTLVTVSSGGGGSGGGGSGGGGSDIVMTQTPLSLPVTPGEPASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLVSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPYTFGGGTKVEIKRTVESKYGPPCPPCPMFWVLVVVGGVLACYSLLVTVAFIIFWVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 441 AA PAT source 1..441 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSGGGGSGGGGSGGGGSEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTVESKYGPPCPPCPMFWVLVVVGGVLACYSLLVTVAFIIFWVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCELRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 20 AA PAT source 1..20 mol_type protein organism synthetic construct METDTLLLWVLLLWVPGSTG 357 AA PAT source 1..357 mol_type protein organism synthetic construct MLLLVTSLLLCELPHPAFLLIPRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFM 5 AA PAT source 1..5 mol_type protein organism synthetic construct REPEAT 1..5 note Repeated for 1, 2, 3, 4, 5, 6, 7 or 8, in particular 3 times GGGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct REPEAT 1..5 note Repeated for 1, 2, 3, 4, 5, 6, 7 or 8, in particular 3 times SGGGG 9 AA PAT source 1..9 mol_type protein organism synthetic construct REPEAT 5..9 note Repeated for 1, 2, 3, 4, 5, 6, 7 or 8, in particular 3 times GGGGSGGGG