WO 54462-739.601 US 63/324,487 2022-03-28 EMPIRICO INC. Darren H. WAKEFIELD MODIFIED OLIGONUCLEOTIDES 50 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..2 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..2 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 8 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caacactctttctcgacaatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..2 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 8 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caacactctttctcgacaatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 8 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caacactctttctcgacaatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 7..9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 14 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside caaccagattgacatcatgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14..16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1..2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 8 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside ctacaaaggtgaactcagatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 3 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 5 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 7 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 9 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 13 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14..16 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 19 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1..2 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 20..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 18 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 4 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 6 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 8 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 10 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 12 mod_base OTHER note 2-O-methyl modified nucleoside ctacaaaggtgaactcagatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 12 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside ttgtcgagaaagagtgttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 12 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside ttgtcgagaaagagtgttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 12 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside ttgtcgagaaagagtgttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 5-vinylphosphonate modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 1 mod_base OTHER note 5-vinylphosphonate modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside tatgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside catgatgtcaatctggttgtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 17..21 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3..5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside tctgagttcacctttgtagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 3..5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9..13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17..21 mod_base OTHER note 2-O-methyl modified nucleoside tctgagttcacctttgtagtt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 6..10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1..5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..21 mod_base OTHER note 2-O-methyl modified nucleoside tctacaaaggtgaactcaatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 19..21 mod_base OTHER note phosphorothioate linkage modified_base 6..10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 1..5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11..21 mod_base OTHER note 2-O-methyl modified nucleoside tctacaaaggtgaactcaatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 1 mod_base OTHER note 5-vinylphosphonate note 2-O-methyl modified nucleoside modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 4 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 12 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside ttgagttcacctttgtagatt 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct modified_base 1..3 mod_base OTHER note phosphorothioate linkage modified_base 19..21 mod_base OTHER note 2-O-methyl modified nucleoside note phosphorothioate linkage modified_base 1 mod_base OTHER note 2-O-methyl modified nucleoside note 5-vinylphosphonate modified_base 2 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 6 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 8 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 10 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 12 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 14 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 16 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 18 mod_base OTHER note 2-fluoro-modified nucleoside modified_base 3..5 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 7 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 9 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 11 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 13 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 15 mod_base OTHER note 2-O-methyl modified nucleoside modified_base 17 mod_base OTHER note 2-O-methyl modified nucleoside ttgagttcacctttgtagatt