674-417 PCT US 63/221,340 2021-07-13 BioNTech SE MULTISPECIFIC BINDING AGENTS AGAINST CD40 AND CD137 IN COMBINATION THERAPY 76 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VH_CD40-001_CDR1 GYTFTEYI 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VH_CD40-001_CDR2 IIPNNGGT 15 AA PAT SOURCE 1..15 MOL_TYPE protein ORGANISM synthetic construct REGION 1..15 NOTE VH_CD40-001_CDR3 TRREVYGRNYYALDY 6 AA PAT SOURCE 1..6 MOL_TYPE protein ORGANISM synthetic construct REGION 1..6 NOTE VL_CD40-001_CDR1 QGINNY 000 9 AA PAT SOURCE 1..9 MOL_TYPE protein ORGANISM synthetic construct REGION 1..9 NOTE VL_CD40-001_CDR3 QQYSNLPYT 122 AA PAT SOURCE 1..122 MOL_TYPE protein ORGANISM synthetic construct REGION 1..122 NOTE VH_CD40-001 EVQLQQSGPDLVKPGASVKISCKTSGYTFTEYIMHWVKQSHGKSLEWIGGIIPNNGGTSYNQKFKDKATMTVDKSSSTGYMELRSLTSEDSAVYYCTRREVYGRNYYALDYWGQGTLVTVSS 107 AA PAT SOURCE 1..107 MOL_TYPE protein ORGANISM synthetic construct REGION 1..107 NOTE VL_CD40-001 DIQMTQTTSSLSASLGDRVTITCSASQGINNYLNWYQQKPDGTVKLLIYYTSSLHSGVPSRFSGSGSGTDYSLTISNLEPEDIATYYCQQYSNLPYTFGGGTKLEIK 122 AA PAT SOURCE 1..122 MOL_TYPE protein ORGANISM synthetic construct REGION 1..122 NOTE VH_CD40-001 humanized EVQLVQSGAEVKKPGASVKVSCKTSGYTFTEYIMHWVRQAPGQGLEWMGGIIPNNGGTSYNQKFQGRVTMTVDKSTSTGYMELSSLRSEDTAVYYCTRREVYGRNYYALDYWGQGTLVTVSS 107 AA PAT SOURCE 1..107 MOL_TYPE protein ORGANISM synthetic construct REGION 1..107 NOTE VL_CD40-001 humanized DIQMTQSPSSLSASVGDRVTITCSASQGINNYLNWYQQKPGKAVKLLIYYTSSLHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQYSNLPYTFGGGTKVEIK 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VH_CD137-009_CDR1 GFSLNDYW 7 AA PAT SOURCE 1..7 MOL_TYPE protein ORGANISM synthetic construct REGION 1..7 NOTE VH_CD137-009_CDR2 IDVGGSL 11 AA PAT SOURCE 1..11 MOL_TYPE protein ORGANISM synthetic construct REGION 1..11 NOTE VH_CD137-009_CDR3 ARGGLTYGFDL 6 AA PAT SOURCE 1..6 MOL_TYPE protein ORGANISM synthetic construct REGION 1..6 NOTE VL_CD137-009_CDR1 EDISSY 000 12 AA PAT SOURCE 1..12 MOL_TYPE protein ORGANISM synthetic construct REGION 1..12 NOTE VL_CD137-009_CDR3 HYYATISGLGVA 114 AA PAT SOURCE 1..114 MOL_TYPE protein ORGANISM synthetic construct REGION 1..114 NOTE VH_CD137-009 QSLEESGGRLVTPGTPLTLTCTVSGFSLNDYWMSWVRQAPGKGLEWIGYIDVGGSLYYASWAKGRFTISRTSTTVDLKMTSLTTEDTATYFCARGGLTYGFDLWGPGTLVTVSS 110 AA PAT SOURCE 1..110 MOL_TYPE protein ORGANISM synthetic construct REGION 1..110 NOTE VL_CD137-009 DIVMTQTPASVSEPVGGTVTINCQASEDISSYLAWYQQKPGQRPKRLIYGASDLASGVPSRFSASGSGTEYALTISDLESADAATYYCHYYATISGLGVAFGGGTEVVVK 117 AA PAT SOURCE 1..117 MOL_TYPE protein ORGANISM synthetic construct REGION 1..117 NOTE VH_CD137-009 humanized EVQLVESGGGLVQPGRSLRLSCTASGFSLNDYWMSWVRQAPGKGLEWVGYIDVGGSLYYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCARGGLTYGFDLWGQGTLVTVSS 110 AA PAT SOURCE 1..110 MOL_TYPE protein ORGANISM synthetic construct REGION 1..110 NOTE VL_CD137-009 humanized DIVMTQSPSSLSASVGDRVTITCQASEDISSYLAWYQQKPGKAPKRLIYGASDLASGVPSRFSASGSGTDYTFTISSLQPEDIATYYCHYYATISGLGVAFGGGTKVEIK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-Fc ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-Fc_F405L ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-Fc_K409R ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-Fc_FEA ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-FEAL-Fc ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT SOURCE 1..330 MOL_TYPE protein ORGANISM synthetic construct REGION 1..330 NOTE IgG1-FEAR-Fc ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT SOURCE 1..107 MOL_TYPE protein ORGANISM synthetic construct REGION 1..107 NOTE Kappa-C RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 106 AA PAT SOURCE 1..106 MOL_TYPE protein ORGANISM synthetic construct REGION 1..106 NOTE Lambda-C GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-Fc without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-Fc_F405L without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-Fc_K409R without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-Fc_FEA without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-FEAL-Fc without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1-FEAR-Fc without C-terminal Lys ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 277 AA PAT SOURCE 1..277 MOL_TYPE protein ORGANISM Homo sapiens MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ 257 AA PAT SOURCE 1..257 MOL_TYPE protein ORGANISM Homo sapiens EPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ 255 AA PAT SOURCE 1..255 MOL_TYPE protein ORGANISM Homo sapiens MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 232 AA PAT SOURCE 1..232 MOL_TYPE protein ORGANISM Homo sapiens LQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 288 AA PAT SOURCE 1..288 MOL_TYPE protein ORGANISM Homo sapiens MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL 290 AA PAT SOURCE 1..290 MOL_TYPE protein ORGANISM Homo sapiens MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET 290 AA PAT SOURCE 1..290 MOL_TYPE protein ORGANISM Macaca fascicularis MRIFAVFIFTIYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLTSLIVYWEMEDKNIIQFVHGEEDLKVQHSNYRQRAQLLKDQLSLGNAALRITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLLNVTSTLRINTTANEIFYCIFRRLDPEENHTAELVIPELPLALPPNERTHLVILGAIFLLLGVALTFIFYLRKGRMMDMKKCGIRVTNSKKQRDTQLEET 223 AA PAT SOURCE 1..223 MOL_TYPE protein ORGANISM Homo sapiens MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFLLTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN 118 AA PAT SOURCE 1..118 MOL_TYPE protein ORGANISM synthetic construct REGION 1..118 NOTE VH_MAB-19-0618 QVQLVESGGGLVQPGTSLRLSCSVSGFSLYSYNMGWVRQAPGKGLEYIGIISGGTIGHYASWAKGRFTISRDTSKTTLYLQMNSLTTEDTATYFCARAFYDDYDYNVWGPGTLVTVSS 111 AA PAT SOURCE 1..111 MOL_TYPE protein ORGANISM synthetic construct REGION 1..111 NOTE VL_MAB-19-0618 AIQLTQSPSSLSASVGGTVTITCQSSQSVYGNNQLSWYQQKPGQPPKLLIYQASKLETGVPSRFRGSGSGTQFTLTISSLQSEDFATYYCAGGYSSSSDTTFGGGTEVVVK 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VH_MAB-19-0618_CDR1 GFSLYSYN 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VH_MAB-19-0618_CDR2 IISGGTIG 10 AA PAT SOURCE 1..10 MOL_TYPE protein ORGANISM synthetic construct REGION 1..10 NOTE VH_MAB-19-0618_CDR3 AFYDDYDYNV 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE VL_MAB-19-0618_CDR1 QSVYGNNQ 000 11 AA PAT SOURCE 1..11 MOL_TYPE protein ORGANISM synthetic construct REGION 1..11 NOTE VL_MAB-19-0618_CDR3 AGGYSSSSDTT 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE IgG1-PD1-MDX1106-FEAL VH CDR1 GITFSNSG 8 AA PAT SOURCE 1..8 MOL_TYPE protein ORGANISM synthetic construct REGION 1..8 NOTE IgG1-PD1-MDX1106-FEAL VH CDR2 IWYDGSKR 6 AA PAT SOURCE 1..6 MOL_TYPE protein ORGANISM synthetic construct REGION 1..6 NOTE IgG1-PD1-MDX1106-FEAL VH CDR3 ATNDDY 6 AA PAT SOURCE 1..6 MOL_TYPE protein ORGANISM synthetic construct REGION 1..6 NOTE IgG1-PD1-MDX1106-FEAL VL CDR1 QSVSSY 000 9 AA PAT SOURCE 1..9 MOL_TYPE protein ORGANISM synthetic construct REGION 1..9 NOTE IgG1-PD1-MDX1106-FEAL VL CDR3 QQSSNWPRT 113 AA PAT SOURCE 1..113 MOL_TYPE protein ORGANISM synthetic construct REGION 1..113 NOTE IgG1-PD1-MDX1106-FEAL VH QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS 107 AA PAT SOURCE 1..107 MOL_TYPE protein ORGANISM synthetic construct REGION 1..107 NOTE IgG1-PD1-MDX1106-FEAL VL EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK 127 AA PAT SOURCE 1..127 MOL_TYPE protein ORGANISM synthetic construct REGION 1..127 NOTE IgG1-b12 VH QVQLVQSGAEVKKPGASVKVSCQASGYRFSNFVIHWVRQAPGQRFEWMGWINPYNGNKEFSAKFQDRVTFTADTSANTAYMELRSLRSADTAVYYCARVGPYSWDDSPQDNYYMDVWGKGTTVIVSS 108 AA PAT SOURCE 1..108 MOL_TYPE protein ORGANISM synthetic construct REGION 1..108 NOTE IgG1-b12 VL EIVLTQSPGTLSLSPGERATFSCRSSHSIRSRRVAWYQHKPGQAPRLVIHGVSNRASGISDRFSGSGSGTDFTLTITRVEPEDFALYYCQVYGASSYTFGQGTKLERK 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1m(f)-L234F-L235E-G236R ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFERGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE IgG1m(f)-L234F-L235E-G236R-K409R ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFERGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 000 5 AA PAT SOURCE 1..5 MOL_TYPE protein ORGANISM synthetic construct REGION 1..5 NOTE VH_MAB-19-0618_CDR1 (Kabat) SYNMG 7 AA PAT SOURCE 1..7 MOL_TYPE protein ORGANISM synthetic construct REGION 1..7 NOTE VH_MAB-19-0618_CDR2 (intersection of Kabat and IMGT) ISGGTIG 16 AA PAT SOURCE 1..16 MOL_TYPE protein ORGANISM synthetic construct REGION 1..16 NOTE VH_MAB-19-0618_CDR2 (Kabat) IISGGTIGHYASWAKG 12 AA PAT SOURCE 1..12 MOL_TYPE protein ORGANISM synthetic construct REGION 1..12 NOTE VH_MAB-19-0618_CDR3 (IMGT) ARAFYDDYDYNV 13 AA PAT SOURCE 1..13 MOL_TYPE protein ORGANISM synthetic construct REGION 1..13 NOTE VL_MAB-19-0618_CDR1 (Kabat) QSSQSVYGNNQLS 7 AA PAT SOURCE 1..7 MOL_TYPE protein ORGANISM synthetic construct REGION 1..7 NOTE VL_MAB-19-0618_CDR2 (Kabat) QASKLET 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE Heavy chain human IgG1-LALA ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 116 AA PAT SOURCE 1..116 MOL_TYPE protein ORGANISM synthetic construct REGION 1..116 NOTE VH_MAB-19-0202 QSVEESGGRLVTPGTPLTLTCTVSGFSLYSYNMGWVRQAPGKGLEYIGIISGGTIGHYASWAKGRFTISKTSSTTVDLKMTSLTTEDTATYFCARAFYDDYDYNVWGPGTLVTVSS 111 AA PAT SOURCE 1..111 MOL_TYPE protein ORGANISM synthetic construct REGION 1..111 NOTE VL_MAB-19-0202 AAVLTQTPSPVSAAVGGTVTISCQSSQSVYGNNQLSWYQQKPGQPPKLLIYQASKLETGVPSRFKGSGSGTQFTLTISDLESDDAATYYCAGGYSSSSDTTFGGGTEVVVK 329 AA PAT SOURCE 1..329 MOL_TYPE protein ORGANISM synthetic construct REGION 1..329 NOTE constant region human HC IgG1m(f)-E430G ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHGALHNHYTQKSLSLSPG 121 AA PAT SOURCE 1..121 MOL_TYPE protein ORGANISM synthetic construct REGION 1..121 NOTE VH_CD52-CAMPATH-1H QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSS 107 AA PAT SOURCE 1..107 MOL_TYPE protein ORGANISM synthetic construct REGION 1..107 NOTE VL_CD52-CAMPATH-1H DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIK 327 AA PAT REGION 1..327 NOTE constant region human HC IgG4 SOURCE 1..327 MOL_TYPE protein ORGANISM synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK