ABV21397USO1 US 63/263,204 2021-10-28 AbbVie Inc Fan Liao ANTI-AMYLOID BETA ANTIBODIES AND METHODS OF USING THE SAME 37 12 AA PAT REGION 1..12 note AC-264713 vH CDR1 sequence source 1..12 mol_type protein organism synthetic construct GFSLSTSGMGVS 16 AA PAT REGION 1..16 note AC-264713 vH CDR2 sequence source 1..16 mol_type protein organism synthetic construct HIYWDDDKRYNPYMKR 11 AA PAT REGION 1..11 note AC-264713 vH CDR3 sequence source 1..11 mol_type protein organism synthetic construct RADDYDVGFAY 11 AA PAT REGION 1..11 note AC-264713 vL CDR1 sequence source 1..11 mol_type protein organism synthetic construct LASQTIGTWLA 7 AA PAT REGION 1..7 note AC-264713 vL CDR2 sequence source 1..7 mol_type protein organism synthetic construct AATSLAD 9 AA PAT REGION 1..9 note AC-264713 vL CDR3 sequence source 1..9 mol_type protein organism synthetic construct QQLYSSPFT 121 AA PAT REGION 1..121 note AC-264713 vH region sequence source 1..121 mol_type protein organism synthetic construct EVQLQESGPGLVKPSQTLSLTCTFSGFSLSTSGMGVSWIRQPPGKGLEWLAHIYWDDDKRYNPYMKRRLTISKDTSKNQVSLKISSVTAADTAVYYCARRADDYDVGFAYWGQGTLVTVSS 107 AA PAT REGION 1..107 note AC-264713 vL region sequence source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSVSASVGDRVTITCLASQTIGTWLAWYQQKPGKSPKLLIYAATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLYSSPFTFGQGTKLEIK 451 AA PAT REGION 1..451 note AC-264713 heavy chain sequence source 1..451 mol_type protein organism synthetic construct EVQLQESGPGLVKPSQTLSLTCTFSGFSLSTSGMGVSWIRQPPGKGLEWLAHIYWDDDKRYNPYMKRRLTISKDTSKNQVSLKISSVTAADTAVYYCARRADDYDVGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note AC-264713 light chain sequence source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSVSASVGDRVTITCLASQTIGTWLAWYQQKPGKSPKLLIYAATSLADGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQLYSSPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 451 AA PAT REGION 1..451 note AC-233661 heavy chain sequence source 1..451 mol_type protein organism synthetic construct QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVSWIRQPSGKGLEWLAHIYWDDDKRYNPYMKRRLTISKDTSSNQVLLKITSVDTADTATYYCARRADDYDVGFAYWGQGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 214 AA PAT REGION 1..214 note AC-233661 light chain sequence source 1..214 mol_type protein organism synthetic construct DIVMTQSPASQSASLGESVTITCLASQTIGTWLAWYQQKPGKSPQLLIYAATSLADGVPSRFSGSGSGTKFSFKISSLQAEDFVSYYCQQLYSSPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 1353 DNA PAT misc_feature 1..1353 note AC-264713 heavy chain coding sequence source 1..1353 mol_type other DNA organism synthetic construct gaagtgcagctgcaagagtccggcccgggcttggtcaagccgtcgcagaccctcagccttacttgcaccttctcgggattctcgctgtccactagcggcatgggcgtgtcgtggatcaggcagcctcctggcaaagggctggagtggcttgcccacatctactgggacgatgacaagagatacaacccctatatgaagcgccgcctgaccatcagcaaggacacctccaaaaaccaagtctcgctgaagatctcctccgtgaccgccgcggataccgccgtgtactactgcgcccggcgggccgacgactatgacgtgggatttgcgtactggggacaggggaccctggtcaccgtgtcctccgcctcaactaagggacccagcgtgttccctctcgccccatcatcgaagtccactagtggcgggaccgctgctctcggttgtctggttaaggactacttcccggaacccgtcaccgtatcatggaactccggtgcactgacatccggcgtgcacaccttcccggccgtgctgcaaagctccggactgtactccctgtcgagcgtggtcactgtgccctcatcaagcctgggtactcagacgtacatttgcaacgtgaaccacaagccgtccaacaccaaggtcgacaagaaagtggagccgaagtcctgcgacaagacccatacttgcccgccgtgcccagcccctgagctgctgggtggaccgagcgtgttcctgttcccacctaaacccaaggacaccctgatgattagccgcacccccgaagtgacctgtgtggtcgtggatgtgtcccacgaagatcccgaagtcaagttcaattggtacgtggacggcgtcgaagtgcataacgccaagactaagccccgcgaggaacagtacaacagcacctaccgggtggtgtccgtgctcactgtcctgcaccaagactggctgaacggaaaggagtacaagtgcaaagtgtccaacaaggcactgccagcgcccatcgagaaaacgatcagcaaggccaagggccagccgagagaacctcaggtctacaccctgccgccatcccgggaagaaatgaccaagaaccaagtgtcccttacctgtctcgtgaagggattctacccttccgacatcgccgtggagtgggagtccaatggacagccggagaacaactacaagactacccctcctgtgctggactccgatggatctttcttcctgtactcgaagctcaccgtggataagtcgcggtggcaacaggggaatgtgttcagctgctccgtgatgcacgaagctctgcataaccactacactcagaagtcgctgtcactctcccccgggaaa 642 DNA PAT misc_feature 1..642 note AC-264713 light chain coding sequence source 1..642 mol_type other DNA organism synthetic construct gacatccagatgacccagtccccgtcctcggtgtcagcgtcagtgggggacagggtcacgatcacttgcctggccagccagaccattggcacttggctggcctggtatcagcagaagcccggaaagtcaccgaagctgttgatctacgccgcaacttccctggccgatggcgtgccctcgcggttctccggttccgggtcgggaactgactttaccctgaccattagctctctgcaacctgaggacttcgccacctactactgtcagcaactgtactcctcgccgttcaccttcggacaaggcaccaagttggaaatcaagcggactgtggcggcacccagcgtgttcatctttcctccatccgacgaacagctgaagtccggtaccgctagcgtggtctgtctcctgaacaacttctacccgcgcgaggccaaggtccagtggaaggtcgacaacgcgctccagagcggcaacagtcaggaatccgtgaccgaacaggactccaaggattcgacctactcgctgtcctccactctcaccctgtccaaagccgattacgagaagcacaaagtgtacgcttgcgaagtgacccatcaaggccttagcagccccgtgacaaagtccttcaatcggggagagtgc 1353 DNA PAT misc_feature 1..1353 note AC-233661 heavy chain coding sequence source 1..1353 mol_type other DNA organism synthetic construct caggttactctgaaagagtctggccctgggatattgcagccctcccagaccctcagtctgacttgttctttctctgggttttcactgagcacttctggtatgggtgtgagctggattcgtcagccctcaggaaagggtctggagtggctggcacacatttactgggatgatgacaagcgctataacccatacatgaagagacggctcacaatctccaaggatacctccagcaaccaggtactcctcaagatcaccagtgtggacactgcagatactgccacatactactgtgctcgaagagctgacgattacgacgtggggtttgcttactggggccaagggactctggtcaccgtctcctcagctaaaacaacagccccatcggtctatccactggcccctgtgtgtggagatacaactggctcctcggtgactctaggatgcctggtcaagggttatttccctgagccagtgaccttgacctggaactctggatccctgtccagtggtgtgcacaccttcccagctgtcctgcagtctgacctctacaccctcagcagctcagtgactgtaacctcgagcacctggcccagccagtccatcacctgcaatgtggcccacccggcaagcagcaccaaggtggacaagaaaattgagcccagagggcccacaatcaagccctgtcctccatgcaaatgcccagcacctaacctcttgggtggaccatccgtcttcatcttccctccaaagatcaaggatgtactcatgatctccctgagccccatagtcacatgtgtggtggtggatgtgagcgaggatgacccagatgtccagatcagctggtttgtgaacaacgtggaagtacacacagctcagacacaaacccatagagaggattacaacagtactctccgggtggtcagtgccctccccatccagcaccaggactggatgagtggcaaggagttcaaatgcaaggtcaacaacaaagacctcccagcgcccatcgagagaaccatctcaaaacccaaagggtcagtaagagctccacaggtatatgtcttgcctccaccagaagaagagatgactaagaaacaggtcactctgacctgcatggtcacagacttcatgcctgaagacatttacgtggagtggaccaacaacgggaaaacagagctaaactacaagaacactgaaccagtcctggactctgatggttcttacttcatgtacagcaagctgagagtggaaaagaagaactgggtggaaagaaatagctactcctgttcagtggtccacgagggtctgcacaatcaccacacgactaagagcttctcccggactccgggtaaa 642 DNA PAT misc_feature 1..642 note AC-233661 light chain coding sequence source 1..642 mol_type other DNA organism synthetic construct gatattgtgatgacccagtctcctgcctcccagtctgcatctctgggagaaagtgtcaccatcacatgcctggcaagtcagaccattggtacatggttagcatggtatcagcagaaaccagggaaatctcctcagctcctgatttatgctgcaaccagcttggcagatggggtcccatcaaggttcagtggtagtggatctggcacaaaattttctttcaagatcagcagcctacaggctgaagattttgtaagttattactgtcaacaactttacagtagtccattcacgttcggctcggggacaaagttggaaataaaacgggctgatgctgcaccaactgtatccatcttcccaccatccagtgagcagttaacatctggaggtgcctcagtcgtgtgcttcttgaacaacttctaccccaaagacatcaatgtcaagtggaagattgatggcagtgaacgacaaaatggcgtcctgaacagttggactgatcaggacagcaaagacagcacctacagcatgagcagcaccctcacgttgaccaaggacgagtatgaacgacataacagctatacctgtgaggccactcacaagacatcaacttcacccattgtcaagagcttcaacaggaatgagtgt 40 AA PAT SITE 1 note MISC_FEATURE - X is pyroglutamic acid source 1..40 mol_type protein organism Homo sapiens XFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 30 AA PAT SITE 1 note MISC_FEATURE - X is pyroglutamic acid source 1..30 mol_type protein organism Homo sapiens XVHHQKLVFFAEDVGSNKGAIIGLMVGGVV 40 AA PAT source 1..40 mol_type protein organism Homo sapiens EFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 40 AA PAT source 1..40 mol_type protein organism Homo sapiens DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV 42 AA PAT source 1..42 mol_type protein organism Homo sapiens DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA 40 AA PAT source 1..40 mol_type protein organism Mus musculus DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV 445 AA PAT REGION 1..445 note PR-1918940 heavy chain sequence source 1..445 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGYDFTRYYINWVRQAPGQGLEWMGWINPGSGNTKYNEKFKGRVTITADESTSTAYMELSSLRSEDTAVYYCAREGITVYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 219 AA PAT REGION 1..219 note PR-1918940 light chain sequence source 1..219 mol_type protein organism synthetic construct DIVMTQTPLSLSVTPGQPASISCKSSQSLLYSRGKTYLNWLLQKPGQSPQLLIYAVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCVQGTHYPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT REGION 1..449 note PR-1770097 heavy chain sequence source 1..449 mol_type protein organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCVRYDHYSGSSDYWGQGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 219 AA PAT REGION 1..219 note PR-1770097 light chain sequence source 1..219 mol_type protein organism synthetic construct DVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFRHDSGYEVHHQK 13 AA PAT REGION 1..13 note Anti-amyloid beta epitope identifying peptide SITE 13 note MISC_FEATURE - Biotinylation source 1..13 mol_type protein organism synthetic construct FRHDSGYEVHHQK 12 AA PAT REGION 1..12 note Anti-amyloid beta epitope identifying peptide SITE 12 note MISC_FEATURE - Biotinylation source 1..12 mol_type protein organism synthetic construct RHDSGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct EFRHDSGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XGRHDSGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFGHDSGFEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFRGDSGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFRHGSGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFRHDGGYEVHHQK 14 AA PAT REGION 1..14 note Anti-amyloid beta epitope identifying peptide SITE 1 note MISC_FEATURE - X is pyroglutamic acid SITE 14 note MISC_FEATURE - Biotinylation source 1..14 mol_type protein organism synthetic construct XFRHDSGGEVHHQK 450 AA PAT REGION 1..450 note AC-264713 heavy chain sequence with C-terminal lysine removed source 1..450 mol_type protein organism synthetic construct EVQLQESGPGLVKPSQTLSLTCTFSGFSLSTSGMGVSWIRQPPGKGLEWLAHIYWDDDKRYNPYMKRRLTISKDTSKNQVSLKISSVTAADTAVYYCARRADDYDVGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG