PCTCN2022142185 CHENGDU ORIGEN BIOTECHNOLOGY CO., LTD. Modified AAV capsid protein and use thereof 28 5 AA PAT source 1..5 mol_type protein organism synthetic construct RGNRQ 10 AA PAT source 1..10 mol_type protein organism synthetic construct QQNTARGNRQ 12 AA PAT source 1..12 mol_type protein organism synthetic construct RGNRQAAQQNTA 9 AA PAT source 1..9 mol_type protein organism synthetic construct RGNRQQNTA 10 AA PAT source 1..10 mol_type protein organism synthetic construct RGNRQQQNTA 5 AA PAT source 1..5 mol_type protein organism synthetic construct SGNTQ 10 AA PAT source 1..10 mol_type protein organism synthetic construct RGNQQNTARQ 12 AA PAT source 1..12 mol_type protein organism synthetic construct RGNQQPRPTSRQ 14 AA PAT source 1..14 mol_type protein organism synthetic construct RGNRQAAQQPTPTS 10 AA PAT source 1..10 mol_type protein organism synthetic construct SQSGASNDNH 432 AA PAT source 1..432 mol_type protein organism synthetic construct SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 526 AA PAT source 1..526 mol_type protein organism synthetic construct GRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPGPGDKTHTCPLCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKATPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 123 AA PAT source 1..123 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVTVSS 124 AA PAT source 1..124 mol_type protein organism synthetic construct DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQ 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCTASGFSLTDYYYMTWVRQAPGKGLEWVGFIDPDDDPYYATWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGGDHNSGWGLDIWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism synthetic construct MEIVMTQSPSTLSASVGDRVIITCQASEIIHSWLAWYQQKPGKAPKLLIYLASTLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQNVYLASTNGANFGQGTKLTVLG 121 AA PAT source 1..121 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIK 12 AA PAT source 1..12 mol_type protein organism synthetic construct RGNRQQQPTPTS 9 AA PAT source 1..9 mol_type protein organism synthetic construct RGDLTTPQQ 9 AA PAT source 1..9 mol_type protein organism synthetic construct RGDLNTPQQ 9 AA PAT source 1..9 mol_type protein organism synthetic construct RGDVSSPQQ 1299 AA PAT source 1..1299 mol_type protein organism synthetic construct AGCGACACCGGCCGGCCCTTCGTGGAGATGTACAGCGAAATCCCTGAGATCATTCACATGACAGAAGGCCGCGAACTGGTGATTCCCTGCAGGGTTACCAGCCCAAACATCACCGTGACCCTGAAGAAGTTCCCCCTGGACACCCTGATCCCTGACGGCAAACGGATCATCTGGGACTCTAGGAAAGGCTTTATCATCTCCAATGCCACATACAAAGAGATTGGCCTGCTGACCTGCGAGGCTACGGTCAACGGCCACCTGTACAAAACAAATTACCTGACCCACAGACAGACCAACACAATCATCGACGTGGTGCTGAGCCCATCCCATGGCATTGAGCTGTCCGTGGGAGAAAAGCTGGTGCTGAATTGTACGGCTAGAACAGAACTTAACGTGGGCATCGATTTCAACTGGGAGTACCCTAGCTCCAAGCACCAGCATAAAAAGCTGGTGAACCGGGACCTGAAGACCCAGTCCGGCAGTGAGATGAAAAAGTTCTTGAGCACCCTGACCATCGATGGAGTGACCCGAAGCGACCAGGGCCTGTACACCTGTGCCGCCTCCTCTGGGCTGATGACAAAAAAGAACAGCACCTTTGTCAGAGTGCACGAGAAGGATAAAACCCACACCTGCCCTCCTTGTCCCGCTCCTGAGCTGCTGGGGGGACCATCTGTGTTCCTGTTCCCCCCCAAGCCCAAGGATACCCTGATGATCAGCCGAACCCCAGAAGTGACCTGCGTGGTGGTGGACGTGTCCCACGAGGACCCAGAGGTGAAATTCAACTGGTATGTGGACGGCGTGGAGGTGCACAATGCCAAGACCAAACCAAGAGAGGAGCAGTATAACTCCACCTACAGGGTGGTGAGCGTGCTGACTGTGCTGCACCAGGATTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTTAGCAATAAAGCTCTGCCCGCCCCCATCGAAAAGACCATTTCCAAAGCCAAAGGGCAGCCAAGGGAGCCCCAGGTGTACACCCTGCCCCCATCTCGGGACGAGCTGACCAAGAACCAGGTGAGTCTCACATGTCTCGTGAAGGGCTTTTACCCTAGCGACATCGCCGTCGAGTGGGAAAGCAACGGACAGCCTGAGAATAACTATAAGACCACACCCCCCGTGCTGGATTCCGACGGCAGTTTTTTCCTGTACTCTAAGCTGACAGTGGACAAATCCCGCTGGCAGCAGGGCAACGTGTTCAGCTGCTCCGTGATGCACGAGGCCCTGCACAATCACTATACACAGAAGAGCCTGAGCCTGAGCCCCGGGAAGTGA 466 AA PAT source 1..466 mol_type protein organism synthetic construct LPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSDTTSSTDICRPHQICNVVAIPGDASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYDSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 1401 DNA PAT source 1..1401 mol_type other DNA organism synthetic construct ctgcccgcccaagtggccttcaccccctatgcccccgagcccggctccacctgtagactgagagagtactacgatcagaccgctcagatgtgctgcagcaagtgcagccccgggcagcacgccaaggtgttctgcaccaagacaagcgacaccgtgtgcgacagctgcgaggacagcacatacacacaactgtggaactgggtgcccgagtgcctgagctgcggcagcagatgcagcagcgaccaagtggagacccaagcctgcacaagagagcagaacagaatctgcacctgcagacccggctggtactgcgccctgagcaagcaagagggctgcagactgtgcgcccccctgagaaagtgtagacccggctttggcgtggctagacccggcacagaaacaagcgacgtcgtgtgcaaaccttgcgctcccggcaccttcagcgacaccacaagcagcaccgacatctgcagaccccatcagatctgcaacgtggtggccatccccggcgacgctagcatggacgccgtctgcacctccacaagccccacccggagcatggctcctggcgccgtgcatctgcctcagcccgtgagcacccggtcccaacacacacagcctacccccgagcctagcaccgctccctccacatccttcctgctccctatggggcctagcccccctgccgaaggcagcaccggcgacgagcccaagagctgcgataaaacccacacatgccccccctgccccgcccctgaactcctgggcgggcctagcgtgttcctgttcccccccaagcccaaggacaccctgatgatcagcagaacccccgaggtgacctgcgtggtcgtggacgtgagccacgaggaccccgaggtgaagttcaactggtacgtggacggcgtggaggtgcacaacgccaagaccaagcctagagaggagcagtacgacagcacctacagagtcgtgagcgtgctgaccgtgctgcaccaagactggctgaacggcaaggagtacaagtgcaaggtgagcaacaaggccctgcccgctcctatcgagaagaccatcagcaaggccaaggggcagcctagagagccccaagtgtacaccctgccccctagcagagaggagatgaccaagaaccaagtgagcctgacctgcctggtgaagggcttctaccctagcgacatcgccgtggagtgggagagcaacgggcagcccgagaacaactacaagaccaccccccccgtgctggacagcgacggcagcttcttcctgtacagcaagctgaccgtggacaagagcagatggcagcaaggcaacgtgttcagctgcagcgtgatgcacgaggccctgcacaaccactacacacagaagagcctgagcctgagccccggctga 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct cacatgaagcagcacgactt 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tcgtccttgaagaagatggt 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct agtccgccatgcccgaaggct