WO JATH-017/05WO 335666-2197 US 63/543,215 2023-10-09 Jasper Therapeutics, Inc. COMPOSITIONS AND METHODS FOR DEPLETION OF MAST CELLS 38 499 AA PAT source 1..499 mol_type protein organism Homo sapiens QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTP 466 AA PAT source 1..466 mol_type protein organism synthetic construct MDWTWRVFCLLAVAPGAHSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGVIYSGNGDTSYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 238 AA PAT source 1..238 mol_type protein organism synthetic construct MVLQTQVFISLLLWISGAYGDIVMTQSPDSLAVSLGERATINCRASESVDIYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 117 AA PAT source 1..117 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGVIYSGNGDTSYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein organism synthetic construct DIVMTQSPDSLAVSLGERATINCRASESVDIYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQNNEDPYTFGGGTKVEIK 4 AA PAT source 1..4 mol_type protein organism synthetic construct YNMH 16 AA PAT source 1..16 mol_type protein organism synthetic construct IYSGNGDTSYNQKFKG 8 AA PAT source 1..8 mol_type protein organism synthetic construct ERDTRFGN 15 AA PAT source 1..15 mol_type protein organism synthetic construct RASESVDIYGNSFMH 7 AA PAT source 1..7 mol_type protein organism synthetic construct LASNLES 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQNNEDPYT 107 AA PAT source 1..107 mol_type protein organism synthetic construct VARIANT 10 note X is an amino acid with an aromatic or aliphatic hydroxyl side chain VARIANT 46 note X is an amino acid with an aliphatic or aliphatic hydroxyl side chain VARIANT 63 note X is an amino acid with an aliphatic hydroxyl side chain VARIANT 80 note X is an amino acid with an aliphatic hydroxyl side chain or is Proline VARIANT 85 note X is an amino acid with a charged or acidic side chain VARIANT 87 note X is an amino acid with an aromatic side chain DIVMTQSPSXLSASVGDRVTITCKASQNVRTNVAWYQQKPGKAPKXLIYSASYRYSGVPDRFXGSGSGTDFTLTISSLQXEDFAXYXCQQYNSYPRTFGGGTKVEIK 117 AA PAT source 1..117 mol_type protein organism synthetic construct VARIANT 11 note X is an amino acid with an aliphatic side chain VARIANT 20 note XH2 is an amino acid with an aliphatic side chain VARIANT 39 note X is an amino acid with a polar or basic side chain VARIANT 69 note X is an amino acid with an aliphatic side chain VARIANT 71 note X is an amino acid with an aliphatic side chain VARIANT 74 note X is an amino acid with an acidic side chain VARIANT 83 note X is an amino acid with an acidic or amide derivative side chain VARIANT 92 note X is an amino acid with an aliphatic hydroxyl side chain QVQLVQSGAEXKKPGASVKXSCKASGYTFTDYYINAVVXQAPGKGLEWIARIYPGSGNTYYNEKFKGRXTXTAXKSTSTAYMXLSSLRSEDXAVYFCARGVYYFDYWGQGTTVTVSS 116 AA PAT source 1..116 mol_type protein organism synthetic construct QVQLKQSGAELVRPGASVKLSCKASGYTFTDYYINWVKQRPGQGLEWIARIYPGSGNTYYNEKFKGKATLTAEKSSSTAYMQLSSLTSEDSAVYFCARGVYYFDYWGQGTTLTVSS 116 AA PAT source 1..116 mol_type protein organism synthetic construct QVQLKQSGAELVRPGASVKLSCKASGYTFTDYYINWVKQRPGQGLEWIARIYPGSGNTYYNEKFKGKATLTAEKSSSTAYMQLSSLTSEDSAVYFCARGVYYFDYWGQGTTLTVSA 108 AA PAT source 1..108 mol_type protein organism synthetic construct DIVMTQSQKFMSTSVGDRVSVTCKASQNVRTNVAWYQQKPGQSPKALIYSASYRYSGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQQYNSYPRTFGGGTKLEIKR 31 AA PAT source 1..31 mol_type protein organism Homo sapiens EKAEATNTGKYTCTNKHGLSNSIYVFVRDPA 21 AA PAT source 1..21 mol_type protein organism Homo sapiens RCPLTDPEVTNYSLKGCQGKP 123 AA PAT source 1..123 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLKISCKGSGYSFTNYWIGWVRQMPGKGLEWMAIINPRDSDTRYRPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARHGRGYEGYEGAFDIWGQGTLVTVSS 5 AA PAT source 1..5 mol_type protein organism synthetic construct NYWIG 17 AA PAT source 1..17 mol_type protein organism synthetic construct IINPRDSDTRYRPSFQG 14 AA PAT source 1..14 mol_type protein organism synthetic construct HGRGYEGYEGAFDI 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRSSQGIRSDLGWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANGFPLTFGGGTKVEIK 11 AA PAT source 1..11 mol_type protein organism synthetic construct RSSQGIRSDLG 7 AA PAT source 1..7 mol_type protein organism synthetic construct DASNLET 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQANGFPLT 5 AA PAT source 1..5 mol_type protein organism synthetic construct SYNMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct VARIANT 12 note X is Ala or Asn VARIANT 16 note X is Lys or Gln VIYSGNGDTSYXQKFXG 8 AA PAT source 1..8 mol_type protein organism synthetic construct ERDTRFGN 15 AA PAT source 1..15 mol_type protein organism synthetic construct VARIANT 4 note X is Asp or Glu VARIANT 11 note X is Asn or Gln RASXSVDIYGXSFMH 7 AA PAT source 1..7 mol_type protein organism synthetic construct LASNLES 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQNNEDPYT 17 AA PAT source 1..17 mol_type protein organism synthetic construct VIYSGNGDTSYAQKFKG 15 AA PAT source 1..15 mol_type protein organism synthetic construct RASESVDIYGQSFMH 117 AA PAT source 1..117 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYMNHWVRQAPGQGLEWMGVIYSGNGDTSYAQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSS 117 AA PAT source 1..117 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYMNHWVRQAPGQGLEWMGVIYSGNGDTSYNQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSS 117 AA PAT source 1..117 mol_type protein organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYMNHWVRQAPGQGLEWMGVIYSGNGDTSYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERDTRFGNWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein organism synthetic construct DIVMTQSPLSLPVTPGEPASISCRASESVDIYGQSFMHWYQQKPGQPPKLLIYLASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQNNEDPYTFGGGTKVEIK