304975WO00P JP 2023-212506 2023-12-15 協和キリン株式会社 KYOWA KIRIN CO., LTD. ２価ＢＥＴ分解薬およびターゲティング分子－薬物複合体 BIVALENT BET DEGRADER AND TARGETING MOLECULE-DRUG CONJUGATE 199 330 AA PAT source 1..330 mol_type protein organism Homo sapiens ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note amino acid sequence of hIgG1 CH variant having S239C mutation organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism Homo sapiens RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 107 AA PAT source 1..107 mol_type protein note amino acid sequence of human kappa chain CL variant having Q124C mutation organism synthetic construct RTVAAPSVFIFPPSDECLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 117 AA PAT source 1..117 mol_type protein note amino acid sequence of anti-CD79b antibody VH organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYTFSSYWIEWVRQAPGKGLEWIGEILPGGGDTNYNEIFKGRATFSADTSKNTAYLQMNSLRAEDTAVYYCTRRVPIRLDYWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein note amino acid sequence of anti-CD79b antibody VL organism synthetic construct DIQLTQSPSSLSASVGDRVTITCKASQSVDYEGDSFLNWYQQKPGKAPKLLIYAASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSNEDPLTFGQGTKVEIK 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-CD19 antibody VH organism synthetic construct QVQLVQPGAEVVKPGASVKLSCKTSGYTFTSNWMHWVKQAPGQGLEWIGEIDPSDSYTNYNQNFQGKAKLTVDKSTSTAYMEVSSLRSDDTAVYYCARGSNPYYYAMDYWGQGTSVTVSS 104 AA PAT source 1..104 mol_type protein note amino acid sequence of anti-CD19 antibody VL organism synthetic construct EIVLTQSPAIMSASPGERVTMTCSASSGVNYMHWYQQKPGTSPRRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEPEDAATYYCHQRGSYTFGGGTKLEIK 121 AA PAT source 1..121 mol_type protein note amino acid sequence of anti-CD22 antibody VH organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYRFTNYWIHWVRQAPGQGLEWIGGINPGNNYATYRRKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTREGYGNYGAWFAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein note amino acid sequence of anti-CD22 antibody VL organism synthetic construct DVQVTQSPSSLSASVGDRVTITCRSSQSLANSYGNTFLSWYLHKPGKAPQLLIYGISNRFSGVPDRFSGSGSGTDFTLTISSLQPEDFATYYCLQGTHQPYTFGQGTKVEIK 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD79b antibody CDRH1 organism synthetic construct SYWIE 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD79b antibody CDRH2 organism synthetic construct EILPGGGDTNYNEIFKG 8 AA PAT source 1..8 mol_type protein note amino acid sequence of anti-CD79b antibody CDRH3 organism synthetic construct RVPIRLDY 15 AA PAT source 1..15 mol_type protein note amino acid sequence of anti-CD79b antibody CDRL1 organism synthetic construct KASQSVDYEGDSFLN 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD79b antibody CDRL2 organism synthetic construct AASNLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD79b antibody CDRL3 organism synthetic construct QQSNEDPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD19 antibody CDRH1 organism synthetic construct SNWMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD19 antibody CDRH2 organism synthetic construct EIDPSDSYTNYNQNFQG 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD19 antibody CDRH3 organism synthetic construct GSNPYYYAMDY 10 AA PAT source 1..10 mol_type protein note amino acid sequence of anti-CD19 antibody CDRL1 organism synthetic construct SASSGVNYMH 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD19 antibody CDRL2 organism synthetic construct DTSKLAS 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD19 antibody CDRL3 organism synthetic construct HQRGSYT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD22 antibody CDRH1 organism synthetic construct NYWIH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD22 antibody CDRH2 organism synthetic construct GINPGNNYATYRRKFQG 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-CD22 antibody CDRH3 organism synthetic construct EGYGNYGAWFAY 16 AA PAT source 1..16 mol_type protein note amino acid sequence of anti-CD22 antibody CDRL1 organism synthetic construct RSSQSLANSYGNTFLS 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD22 antibody CDRL2 organism synthetic construct GISNRFS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD22 antibody CDRL3 organism synthetic construct LQGTHQPYT 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-HER2 antibody VH organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-HER2 antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK 118 AA PAT source 1..118 mol_type protein note amino acid sequence of anti-DLL3 antibody VH organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGEPTYADDFKGRVTMTTDTSTSTAYMELRSLRSDDTAVYYCARIGDSSPSDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-DLL3 antibody VL organism synthetic construct EIVMTQSPATLSVSPGERATLSCKASQSVSNDVVWYQQKPGQAPRLLIYYASNRYTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQDYTSPWTFGQGTKLEIK 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-GM2 antibody VH organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYTFTDYNMDWVKQSPGQGLEWMGYIYPNNGGTGYNQKFKSKVTITVDTSTSTAYMELHSLRSEDTAVYYCATYGHYYGYMFAYWGQGTLVTVSS 106 AA PAT source 1..106 mol_type protein note amino acid sequence of anti-GM2 antibody VL organism synthetic construct DIQLTQSPSSLSASPGDRVTITCSASSSVSYMHWFQQKPGKAPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISRLQPEDIATYYCQQRSSYPYTFGGGTKVEIK 128 AA PAT source 1..128 mol_type protein note amino acid sequence of anti-EphA2 antibody VH organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYMMAWVRQAPGKGLEWVSRIGPSGGPTHYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGYDSGYDYVAVAGPAEYFQHWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-EphA2 antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQSISTWLAWYQQKPGKAPKLLIYKASNLHTGVPSRFSGSGSGTEFSLTISGLQPDDFATYYCQQYNSYSRTFGQGTKVEIK 119 AA PAT source 1..119 mol_type protein note amino acid sequence of anti-FAP antibody VH organism synthetic construct QVQLKQSGAELVKPGASVKLSCKTSGYTFTENIIHWVKQRSGQGLEWIGWFHPGSGSIKYNEKKDKATLTADKSSSTVYMELSRLTSEDSAVYFCARHGGTGRGAMDYWGQGTSVTVSS 112 AA PAT source 1..112 mol_type protein note amino acid sequence of anti-FAP antibody VL organism synthetic construct DILMTQSPASSVVSLSGQRATISCRASKSVSTSAYSYMHWYQQKPGQPPKLLIYLASNLESGVPPRFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPYTFGGGTKLEIK 119 AA PAT source 1..119 mol_type protein note amino acid sequence of anti-SSTR2 antibody VH organism synthetic construct EVKLVESGGGLVQPGGSLRLSCATSGFTFTDYHLNWVRQPPGKALEWLALIRNKRYGYRTEYSASVKGRFTISRDNSQSILYLQMNTLRAEDSATYYCARDFYDPFAYWGQGTLVTVSA 112 AA PAT source 1..112 mol_type protein note amino acid sequence of anti-SSTR2 antibody VL organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQRPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPFTFGSGTKLEIK 117 AA PAT source 1..117 mol_type protein note amino acid sequence of anti-CD30 antibody VH organism synthetic construct QIQLQQSGPEVVKPGASVKISCKASGYTFTDYYITWVKQKPGQGLEWIGWIYPGSGNTKYNEKFKGKATLTVDTSSSTAFMQLSSLTSEDTAVYFCANYGNYWFAYWGQGTQVTVSA 111 AA PAT source 1..111 mol_type protein note amino acid sequence of anti-CD30 antibody VL organism synthetic construct DIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKVLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPWTFGGGTKLEIK 121 AA PAT source 1..121 mol_type protein note amino acid sequence of anti-BCMA antibody VH organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNYWMHWVRQAPGQGLEWMGATYRGHSDTYYNQKFKGRVTITADKSTSTAYMELSSLRSEDTAVYYCARGAIYDGYDVLDNWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-BCMA antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKLLIYYTSNLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYRKLPWTFGQGTKLEIK 117 AA PAT source 1..117 mol_type protein note amino acid sequence of anti-CD33 antibody VH organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYDINWVRQAPGQGLEWIGWIYPGDGSTKYNEKFKAKATLTADTSTSTAYMELRSLRSDDTAVYYCASGYEDAMDYWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD33 antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTINCKASQDINSYLSWFQQKPGKAPKTLIYRANRLVDGVPSRFSGSGSGQDYTLTISSLQPEDFATYYCLQYDEFPLTFGGGTKVEIK 124 AA PAT source 1..124 mol_type protein note amino acid sequence of anti-FoLRalpha antibody VH organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFTDFYMNWVRQPPGKAPEWLGFIRNKANGYTTEFNPSVKGRFTISRDNSKNSLYLQMNSLKTEDTATYYCARTLYGYAYYYVMDAWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-FoLRalpha antibody VL organism synthetic construct DIQMTQSPSSLSASLGDRVTITCRTSEDIFRNLAWYQQKPGKAPKLLIYDTNRLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQYDNYPLTFGQGTKLEIK 115 AA PAT source 1..115 mol_type protein note amino acid sequence of anti-CD25 antibody VH organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGGTFSRYIINWVRQAPGQGLEWMGRIIPILGVENYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARKDWFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD25 antibody VL organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTFGGGTKVEIK 125 AA PAT source 1..125 mol_type protein note amino acid sequence of anti-CADM1 antibody VH organism synthetic construct QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSGVGVGWIRQPPGKALEWLALIYWDDDKRYSPSLKSRLTITKDTSKNQVVLTMTNMDPVDTATYYCAHRRVEWVTLAGNWFDPWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CADM1 antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISNLQPEDFATYYCQQYNSYPLTFGGGTKVEIK 122 AA PAT source 1..122 mol_type protein note amino acid sequence of anti-CLL1 antibody VH organism synthetic construct EVQLVQSGAEVKKPGASVKVSCKASGYSFTDYYMHWVRQAPGQGLEWIGRINPYAGAAFYSQNFKDRVTLTVDTSTSTAYLELSSLRSEDTAVYYCAIERGADLEGYAMDYWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein note amino acid sequence of anti-CLL1 antibody VL organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQSVSTSSYNYMHWYQQKPGKPPKLLIKYASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHSWEIPLTFGQGTKVEIK 122 AA PAT source 1..122 mol_type protein note amino acid sequence of anti-CD38 antibody VH organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD38 antibody VL organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIK 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-CD74 antibody VH organism synthetic construct QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGVNWIKQAPGQGLQWMGWINPNTGEPTFDDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCSRSRGKNEAWFAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein note amino acid sequence of anti-CD74 antibody VL organism synthetic construct DIQLTQSPLSLPVTLGQPASISCRSSQSLVHRNGNTYLHWFQQRPGQSPRLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYFCSQSSHVPPTFGAGTRLEIK 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-CD79b (G4055) antibody VH organism synthetic construct QVQLVESGGGVVQSGRSLRLSCATSGFTFSIYGMHWVRQAPGKGLEWVALIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGGDYDDHYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody VL organism synthetic construct AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSFPLTFGGGTKVEIK 125 AA PAT source 1..125 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody VH organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFDGYAMHWVRQAPGKGLEWVSGISWDGRHIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCSKDKGTVTSYYYYYGTDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody VL organism synthetic construct AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKAPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPFTFGPGTKVDIK 120 AA PAT source 1..120 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody VH organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSIYGMHWVRQAPGKGLEWVALIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGGDYDYHYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody VL organism synthetic construct AIQLTQSPSSLSASVGDRVTITCRASQGISSALAWYQQKPGKPPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSFPLTFGGGTKVEIK 126 AA PAT source 1..126 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody VH organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSIYGMHWVRQAPGKGLEWVALIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGGDYYDSGSSYYHYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody VL organism synthetic construct AIQLTQSPSSLSASVGDRVTITCRASQGVSSALAWYQQKPGKPPKLLIYDASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSFPLTFGGGTKVEIK 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-HER2 antibody CDRH1 organism synthetic construct DTYIH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-HER2 antibody CDRH2 organism synthetic construct RIYPTNGYTRYADSVKG 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-HER2 antibody CDRH3 organism synthetic construct WGGDGFYAMDY 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-HER2 antibody CDRL1 organism synthetic construct RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-HER2 antibody CDRL2 organism synthetic construct SASFLYS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-HER2 antibody CDRL3 organism synthetic construct QQHYTTPPT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRH1 organism synthetic construct NYGMN 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRH2 organism synthetic construct WINTYTGEPTYADDFKG 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRH3 organism synthetic construct IGDSSPSDY 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRL1 organism synthetic construct KASQSVSNDVV 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRL2 organism synthetic construct YASNRYT 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-DLL3 antibody CDRL3 organism synthetic construct QQDYTSPWT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-GM2 antibody CDRH1 organism synthetic construct DYNMD 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-GM2 antibody CDRH2 organism synthetic construct YIYPNNGGTGYNQKFKS 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-GM2 antibody CDRH3 organism synthetic construct TYGHYYGYMFAY 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-GM2 antibody CDRL1 organism synthetic construct SASSSVS 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-GM2 antibody CDRL2 organism synthetic construct STSNLAS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-GM2 antibody CDRL3 organism synthetic construct QQRSSYPYT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRH1 organism synthetic construct HYMMA 18 AA PAT source 1..18 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRH2 organism synthetic construct SRIGPSGGPTHYADSVKG 20 AA PAT source 1..20 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRH3 organism synthetic construct GYDSGYDYVAVAGPAEYFQH 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRL1 organism synthetic construct RASQSISTWLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRL2 organism synthetic construct KASNLHT 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-EphA2 antibody CDRL3 organism synthetic construct QQYNSYSRT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-FAP antibody CDRH1 organism synthetic construct ENIIH 14 AA PAT source 1..14 mol_type protein note amino acid sequence of anti-FAP antibody CDRH2 organism synthetic construct WFHPGSGSIKYNEK 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-FAP antibody CDRH3 organism synthetic construct HGGTGRGAMDY 15 AA PAT source 1..15 mol_type protein note amino acid sequence of anti-FAP antibody CDRL1 organism synthetic construct RASKSVSTSAYSYMH 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-FAP antibody CDRL2 organism synthetic construct LASNLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-FAP antibody CDRL3 organism synthetic construct QHSRELPYT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRH1 organism synthetic construct DYHLN 19 AA PAT source 1..19 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRH2 organism synthetic construct LIRNKRYGYRTEYSASVKG 8 AA PAT source 1..8 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRH3 organism synthetic construct DFYDPFAY 16 AA PAT source 1..16 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRL1 organism synthetic construct RSSQSLVHSNGNTYLH 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRL2 organism synthetic construct KVSNRFS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-SSTR2 antibody CDRL3 organism synthetic construct SQSTHVPFT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD30 antibody CDRH1 organism synthetic construct DYYIT 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD30 antibody CDRH2 organism synthetic construct WIYPGSGNTKYNEKFKG 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD30 antibody CDRH3 organism synthetic construct NYGNYWFAY 15 AA PAT source 1..15 mol_type protein note amino acid sequence of anti-CD30 antibody CDRV1 organism synthetic construct KASQSVDFDGDSYMN 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD30 antibody CDRL2 organism synthetic construct AASNLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD30 antibody CDRL3 organism synthetic construct QQSNEDPWT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-BCMA antibody CDRH1 organism synthetic construct NYWMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-BCMA antibody CDRH2 organism synthetic construct ATYRGHSDTYYNQKFKG 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-BCMA antibody CDRH3 organism synthetic construct GAIYDGYDVLDN 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-BCMA antibody CDRL1 organism synthetic construct SASQDISNYLN 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-BCMA antibody CDRL2 organism synthetic construct YTSNLHS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-BCMA antibody CDRL3 organism synthetic construct QQYRKLPWT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD33 antibody CDRH1 organism synthetic construct NYDIN 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD33 antibody CDRH2 organism synthetic construct WIYPGDGSTKYNEKFKA 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD33 antibody CDRH3 organism synthetic construct SGYEDAMDY 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD33 antibody CDRL1 organism synthetic construct KASQDINSYLS 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD33 antibody CDRL2 organism synthetic construct RANRLVD 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD33 antibody CDRL3 organism synthetic construct LQYDEFPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRH1 organism synthetic construct DFYMN 19 AA PAT source 1..19 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRH2 organism synthetic construct FIRNKANGYTTEFNPSVKG 13 AA PAT source 1..13 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRH3 organism synthetic construct TLYGYAYYYVMDA 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRL1 organism synthetic construct RTSEDIFRNLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRL2 organism synthetic construct DTNRLAD 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-FoLRalpha antibody CDRL3 organism synthetic construct QQYDNYPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD25 antibody CDRH1 organism synthetic construct RYIIN 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD25 antibody CDRH2 organism synthetic construct RIIPILGVENYAQKFQG 6 AA PAT source 1..6 mol_type protein note amino acid sequence of anti-CD25 antibody CDRH3 organism synthetic construct KDWFDY 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD25 antibody CDRL1 organism synthetic construct RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD25 antibody CDRL2 organism synthetic construct GASSRAT 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD25 antibody CDRL3 organism synthetic construct QQYGSSPLT 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRH1 organism synthetic construct TSGVGVG 16 AA PAT source 1..16 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRH2 organism synthetic construct LIYWDDDKRYSPSLKS 15 AA PAT source 1..15 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRH3 organism synthetic construct RRVEWVTLAGNWFDP 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRL1 organism synthetic construct RASQGISSWLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRL2 organism synthetic construct AASSLQS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CADM1 antibody CDRL3 organism synthetic construct QQYNSYPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRH1 organism synthetic construct DYYMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRH2 organism synthetic construct RINPYAGAAFYSQNFKD 14 AA PAT source 1..14 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRH3 organism synthetic construct IERGADLEGYAMDY 15 AA PAT source 1..15 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRL1 organism synthetic construct RASQSVSTSSYNYMH 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRL2 organism synthetic construct YASNLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CLL1 antibody CDRL3 organism synthetic construct QHSWEIPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD38 antibody CDRH1 organism synthetic construct SFAMS 18 AA PAT source 1..18 mol_type protein note amino acid sequence of anti-CD38 antibody CDRH2 organism synthetic construct SAISGSGGGTYYADSVKG 13 AA PAT source 1..13 mol_type protein note amino acid sequence of anti-CD38 antibody CDRH3 organism synthetic construct DKILWFGEPVFDY 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD38 antibody CDRL1 organism synthetic construct RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD38 antibody CDRL2 organism synthetic construct DASNRAT 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD38 antibody CDRL3 organism synthetic construct QQRSNWPPT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD74 antibody CDRH1 organism synthetic construct NYGVN 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD74 antibody CDRH2 organism synthetic construct WINPNTGEPTFDDDFKG 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD74 antibody CDRH3 organism synthetic construct SRGKNEAWFAY 16 AA PAT source 1..16 mol_type protein note amino acid sequence of anti-CD74 antibody CDRL1 organism synthetic construct RSSQSLVHRNGNTYLH 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD74 antibody CDRL2 organism synthetic construct TVSNRFS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD74 antibody CDRL3 organism synthetic construct SQSSHVPPT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRH1 organism synthetic construct IYGMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRH2 organism synthetic construct LIWYDGSNKYYADSVKG 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRH3 organism synthetic construct GGDYDDHYGMDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRL1 organism synthetic construct RASQGISSALA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRL2 organism synthetic construct DASSLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD79b(G4055) antibody CDRL3 organism synthetic construct QQFNSFPLT 6 AA PAT source 1..6 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRH1 organism synthetic construct DGYAMH 18 AA PAT source 1..18 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRH2 organism synthetic construct SGISWDGRHIGYADSVKG 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRH3 organism synthetic construct KDKGTVTSYYYYYGTDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRL1 organism synthetic construct RASQGISSALA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRL2 organism synthetic construct DASSLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD79b(G4022) antibody CDRL3 organism synthetic construct QQFNSYPFT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRH1 organism synthetic construct IYGMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRH2 organism synthetic construct LIWYDGSNKYYADSVKG 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRH3 organism synthetic construct GGDYDYHYGMDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRL1 organism synthetic construct RASQGISSALA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRL2 organism synthetic construct DASSLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD79b(G4046) antibody CDRL3 organism synthetic construct QQFNSFPLT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRH1 organism synthetic construct IYGMH 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRH2 organism synthetic construct LIWYDGSNKYYADSVKG 18 AA PAT source 1..18 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRH3 organism synthetic construct GGDYYDSGSSYYHYGMDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRL1 organism synthetic construct RASQGVSSALA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRL2 organism synthetic construct DASSLES 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-CD79b(G4047) antibody CDRL3 organism synthetic construct QQFNSFPLT 327 AA PAT source 1..327 mol_type protein note amino acid sequence of hIgG4 CH variant having R409K and S239C mutation organism synthetic construct ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 330 AA PAT source 1..330 mol_type protein note amino acid sequence of hIgG1 CH variant having S239C and H435F mutation organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPCVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNFYTQKSLSLSPGK 117 AA PAT source 1..117 mol_type protein note amino acid sequence of anti-NECTIN4 antibody VH organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYNMNWVRQAPGKGLEWVSYISSSSSTIYYADSVKGRFTISRDNAKNSLSLQMNSLRDEDTAVYYCARAYYYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-NECTIN4 antibody VL organism synthetic construct DIQMTQSPSSVSASVGDRVTITCRASQGISGWLAWYQQKPGKAPKFLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQANSFPPTFGGGTKVEIK 121 AA PAT source 1..121 mol_type protein note amino acid sequence of anti-TROP2 antibody VH organism synthetic construct QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSS 107 AA PAT source 1..107 mol_type protein note amino acid sequence of anti-TROP2 antibody VL organism synthetic construct DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIK 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRH1 organism synthetic construct SYNMN 18 AA PAT source 1..18 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRH2 organism synthetic construct SYISSSSSTIYYADSVKG 8 AA PAT source 1..8 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRH3 organism synthetic construct AYYYGMDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRL1 organism synthetic construct RASQGISGWLA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRL2 organism synthetic construct AASTLQS 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-NECTIN4 antibody CDRL3 organism synthetic construct QQANSFPPT 5 AA PAT source 1..5 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRH1 organism synthetic construct NYGMN 17 AA PAT source 1..17 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRH2 organism synthetic construct WINTYTGEPTYTDDFKG 12 AA PAT source 1..12 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRH3 organism synthetic construct GGFGSSYWYFDV 11 AA PAT source 1..11 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRL1 organism synthetic construct KASQDVSIAVA 7 AA PAT source 1..7 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRL2 organism synthetic construct SASYRYT 9 AA PAT source 1..9 mol_type protein note amino acid sequence of anti-TROP2 antibody CDRL3 organism synthetic construct QQHYITPLT 106 AA PAT source 1..106 mol_type protein note amino acid sequence of the heavy chain of the antigen-binding fragment of anti-CD79b antibody organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT