WO 116983-5097-WO US US 63/242,373 2021-09-09 Iovance Biotherapeutics, Inc. PROCESSES FOR GENERATING TIL PRODUCTS USING PD-1 TALEN KNOCKDOWN 241 450 AA PAT REGION 1..450 note Synthetic Muromonab heavy chain source 1..450 mol_type protein organism synthetic construct QVQLQQSGAELARPGASVKMSCKASGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 213 AA PAT REGION 1..213 note Synthetic Muromonab light chain source 1..213 mol_type protein organism synthetic construct QIVLTQSPAIMSASPGEKVTMTCSASSSVSYMNWYQQKSGTSPKRWIYDTSKLASGVPAHFRGSGSGTSYSLTISGMEAEDAATYYCQQWSSNPFTFGSGTKLEINRADTAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 134 AA PAT REGION 1..134 note Synthetic recombinant human IL-2 (rhIL-2) source 1..134 mol_type protein organism synthetic construct MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 132 AA PAT REGION 1..132 note Synthetic Aldesleukin source 1..132 mol_type protein organism synthetic construct PTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLT 133 AA PAT REGION 1..133 note Synthetic IL-2 form source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 303 AA PAT REGION 1..303 note Synthetic IL-2 form source 1..303 mol_type protein organism synthetic construct SKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLTGGSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQGSGGGSELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTG 452 AA PAT REGION 1..452 note Synthetic IL-2 form source 1..452 mol_type protein organism synthetic construct MDAMKRGLCCVLLLCGAVFVSARRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDESGSGGASSESSASSDGPHPVITESRASSESSASSDGPHPVITESREPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 16 AA PAT REGION 1..16 note Synthetic mucin domain polypeptide source 1..16 mol_type protein organism synthetic construct SESSASSDGPHPVITP 130 AA PAT REGION 1..130 note Synthetic recombinant human IL-4 (rhIL-4) source 1..130 mol_type protein organism synthetic construct MHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS 153 AA PAT REGION 1..153 note Synthetic recombinant human IL-7 (rhIL-7) source 1..153 mol_type protein organism synthetic construct MDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCLNNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQVKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH 115 AA PAT REGION 1..115 note Synthetic recombinant human IL-15 (rhIL-15) source 1..115 mol_type protein organism synthetic construct MNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS 132 AA PAT REGION 1..132 note Synthetic recombinant human IL-21 (rhIL-21) source 1..132 mol_type protein organism synthetic construct MQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS 153 AA PAT REGION 1..153 note Synthetic IL-2 source 1..153 mol_type protein organism synthetic construct MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note Synthetic IL-2 mutein source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 133 AA PAT REGION 1..133 note Synthetic IL-2 mutein source 1..133 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT 145 AA PAT REGION 1..145 note Synthetic HCDR1_IL-2 source 1..145 mol_type protein organism synthetic construct GFSLAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMSVG 16 AA PAT REGION 1..16 note Synthetic HCDR2 source 1..16 mol_type protein organism synthetic construct DIWWDDKKDYNPSLKS 10 AA PAT REGION 1..10 note Synthetic HCDR3 source 1..10 mol_type protein organism synthetic construct SMITNWYFDV 141 AA PAT REGION 1..141 note Synthetic HCDR1_IL-2 kabat source 1..141 mol_type protein organism synthetic construct APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMSVG 16 AA PAT REGION 1..16 note Synthetic HCDR2 kabat source 1..16 mol_type protein organism synthetic construct DIWWDDKKDYNPSLKS 10 AA PAT REGION 1..10 note Synthetic HCDR3 kabat source 1..10 mol_type protein organism synthetic construct SMITNWYFDV 142 AA PAT REGION 1..142 note Synthetic HCDR1_IL-2 clothia source 1..142 mol_type protein organism synthetic construct GFSLAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGM 5 AA PAT REGION 1..5 note Synthetic HCDR2 clothia source 1..5 mol_type protein organism synthetic construct WWDDK 10 AA PAT REGION 1..10 note Synthetic HCDR3 clothia source 1..10 mol_type protein organism synthetic construct SMITNWYFDV 143 AA PAT REGION 1..143 note Synthetic HCDR1_IL-2 IMGT source 1..143 mol_type protein organism synthetic construct GFSLAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMS 7 AA PAT REGION 1..7 note Synthetic HCDR2 IMGT source 1..7 mol_type protein organism synthetic construct IWWDDKK 12 AA PAT REGION 1..12 note Synthetic HCDR3 IMGT source 1..12 mol_type protein organism synthetic construct ARSMITNWYFDV 253 AA PAT REGION 1..253 note Synthetic VH source 1..253 mol_type protein organism synthetic construct QVTLRESGPALVKPTQTLTLTCTFSGFSLAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMSVGWIRQPPGKALEWLADIWWDDKKDYNPSLKSRLTISKDTSKNQVVLKVTNMDPADTATYYCARSMITNWYFDVWGAGTTVTVSS 533 AA PAT REGION 1..533 note Synthetic Heavy chain source 1..533 mol_type protein organism synthetic construct QMILNGINNYKNPKLTAMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMSVGWIRQPPGKALEWLADIWWDDKKDYNPSLKSRLTISKDTSKNQVVLKVTNMDPADTATYYCARSMITNWYFDVWGAGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 10 AA PAT REGION 1..10 note Synthetic LCDR1 kabat source 1..10 mol_type protein organism synthetic construct KAQLSVGYMH 7 AA PAT REGION 1..7 note Synthetic LCDR2 kabat source 1..7 mol_type protein organism synthetic construct DTSKLAS 9 AA PAT REGION 1..9 note Synthetic LCDR3 kabat source 1..9 mol_type protein organism synthetic construct FQGSGYPFT 6 AA PAT REGION 1..6 note Synthetic LCDR1 chothia source 1..6 mol_type protein organism synthetic construct QLSVGY 000 6 AA PAT REGION 1..6 note Synthetic LCDR3 chothia source 1..6 mol_type protein organism synthetic construct GSGYPF 106 AA PAT REGION 1..106 note Synthetic VL source 1..106 mol_type protein organism synthetic construct DIQMTQSPSTLSASVGDRVTITCKAQLSVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKLEIK 213 AA PAT REGION 1..213 note Synthetic Light chain source 1..213 mol_type protein organism synthetic construct DIQMTQSPSTLSASVGDRVTITCKAQLSVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 583 AA PAT REGION 1..583 note Synthetic Light chain source 1..583 mol_type protein organism synthetic construct QVTLRESGPALVKPTQTLTLTCTFSGFSLAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTAKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLTSTSGMSVGWIRQPPGKALEWLADIWWDDKKDYNPSLKSRLTISKDTSKNQVVLKVTNMDPADTATYYCARSMITNWYFDVWGAGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 213 AA PAT REGION 1..213 note Synthetic Light chain source 1..213 mol_type protein organism synthetic construct DIQMTQSPSTLSASVGDRVTITCKAQLSVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 255 AA PAT REGION 1..255 note Synthetic human 4-1BB, Tumor necrosis factor receptorsuperfamily, member 9 (Homo sapiens) source 1..255 mol_type protein organism synthetic construct MGNSCYNIVATLLLVLNFERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALLFLLFFLTLRFSVVKRGRKKLLYIFKQPFMRPVQTTQEEDGCSCRFPEEEEGGCEL 256 AA PAT REGION 1..256 note Synthetic murine 4-1BB, Tumor necrosis factor receptorsuperfamily, member 9 (Mus musculus) source 1..256 mol_type protein organism synthetic construct MGNNCYNVVVIVLLLVGCEKVGAVQNSCDNCQPGTFCRKYNPVCKSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRCEKDCRPGQELTKQGCKTCSLGTFNDQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVCGPPVVSFSPSTTISVTPEGGPGGHSLQVLTLFLALTSALLLALIFITLLFSVLKWIRKKFPHIFKQPFKKTTGAAQEEDACSCRCPQEEEGGGGGYEL 441 AA PAT REGION 1..441 note Synthetic heavy chain for utomilumab source 1..441 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 214 AA PAT REGION 1..214 note Synthetic light chain for utomilumab source 1..214 mol_type protein organism synthetic construct SYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 116 AA PAT REGION 1..116 note Synthetic heavy chain variable region for utomilumab source 1..116 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Synthetic light chain variable region for utomilumab source 1..108 mol_type protein organism synthetic construct SYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVL 6 AA PAT REGION 1..6 note Synthetic heavy chain CDR1 for utomilumab source 1..6 mol_type protein organism synthetic construct STYWIS 17 AA PAT REGION 1..17 note Synthetic heavy chain CDR2 for utomilumab source 1..17 mol_type protein organism synthetic construct KIYPGDSYTNYSPSFQG 8 AA PAT REGION 1..8 note Synthetic heavy chain CDR3 for utomilumab source 1..8 mol_type protein organism synthetic construct RGYGIFDY 11 AA PAT REGION 1..11 note Synthetic light chain CDR1 for utomilumab source 1..11 mol_type protein organism synthetic construct SGDNIGDQYAH 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for utomilumab source 1..7 mol_type protein organism synthetic construct QDKNRPS 11 AA PAT REGION 1..11 note Synthetic light chain CDR3 for utomilumab source 1..11 mol_type protein organism synthetic construct ATYTGFGSLAV 448 AA PAT REGION 1..448 note Synthetic heavy chain for urelumab source 1..448 mol_type protein organism synthetic construct QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 216 AA PAT REGION 1..216 note Synthetic light chain for urelumab source 1..216 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFCGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for urelumab source 1..120 mol_type protein organism synthetic construct MKHLWFFLLLVAAPRWVLSQVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGP 110 AA PAT REGION 1..110 note Synthetic variable light chain for urelumab source 1..110 mol_type protein organism synthetic construct MEAPAQLLFLLLLWLPDTTGEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQ 5 AA PAT REGION 1..5 note Synthetic heavy chain CDR1 for urelumab source 1..5 mol_type protein organism synthetic construct GYYWS 16 AA PAT REGION 1..16 note Synthetic heavy chain CDR2 for urelumab source 1..16 mol_type protein organism synthetic construct EINHGGYVTYNPSLES 13 AA PAT REGION 1..13 note Synthetic heavy chain CDR3 for urelumab source 1..13 mol_type protein organism synthetic construct DYGPGNYDWYFDL 11 AA PAT REGION 1..11 note Synthetic light chain CDR1 for urelumab source 1..11 mol_type protein organism synthetic construct RASQSVSSYLA 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for urelumab source 1..7 mol_type protein organism synthetic construct DASNRAT 11 AA PAT REGION 1..11 note Synthetic light chain CDR3 for urelumab source 1..11 mol_type protein organism synthetic construct QQRSDWPPALT 230 AA PAT REGION 1..230 note Synthetic Fc domain source 1..230 mol_type protein organism synthetic construct KSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 22 AA PAT REGION 1..22 note Synthetic linker source 1..22 mol_type protein organism synthetic construct GGPGSSKSCDKTHTCPPCPAPE 22 AA PAT REGION 1..22 note Synthetic linker source 1..22 mol_type protein organism synthetic construct GGSGSSKSCDKTHTCPPCPAPE 27 AA PAT REGION 1..27 note Synthetic linker source 1..27 mol_type protein organism synthetic construct GGPGSSSSSSSKSCDKTHTCPPCPAPE 27 AA PAT REGION 1..27 note Synthetic linker source 1..27 mol_type protein organism synthetic construct GGSGSSSSSSSKSCDKTHTCPPCPAPE 29 AA PAT REGION 1..29 note Synthetic linker source 1..29 mol_type protein organism synthetic construct GGPGSSSSSSSSSKSCDKTHTCPPCPAPE 29 AA PAT REGION 1..29 note Synthetic linker source 1..29 mol_type protein organism synthetic construct GGSGSSSSSSSSSKSCDKTHTCPPCPAPE 24 AA PAT REGION 1..24 note Synthetic linker source 1..24 mol_type protein organism synthetic construct GGPGSSGSGSSDKTHTCPPCPAPE 23 AA PAT REGION 1..23 note Synthetic linker source 1..23 mol_type protein organism synthetic construct GGPGSSGSGSDKTHTCPPCPAPE 21 AA PAT REGION 1..21 note Synthetic linker source 1..21 mol_type protein organism synthetic construct GGPSSSGSDKTHTCPPCPAPE 25 AA PAT REGION 1..25 note Synthetic linker source 1..25 mol_type protein organism synthetic construct GGSSSSSSSSGSDKTHTCPPCPAPE 246 AA PAT REGION 1..246 note Synthetic Fc domain source 1..246 mol_type protein organism synthetic construct METDTLLLWVLLLWVPAGNGDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 11 AA PAT REGION 1..11 note Synthetic linker source 1..11 mol_type protein organism synthetic construct SGSGSGSGSGS 12 AA PAT REGION 1..12 note Synthetic linker source 1..12 mol_type protein organism synthetic construct SSSSSSGSGSGS 16 AA PAT REGION 1..16 note Synthetic linker source 1..16 mol_type protein organism synthetic construct SSSSSSGSGSGSGSGS 254 AA PAT REGION 1..254 note Synthetic 4-1BBL source 1..254 mol_type protein organism synthetic construct MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE 168 AA PAT REGION 1..168 note Synthetic 4-1BBL soluble domain source 1..168 mol_type protein organism synthetic construct LRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE 118 AA PAT REGION 1..118 note Synthetic variable heavy chain for 4B4-1-1 version 1 source 1..118 mol_type protein organism synthetic construct QVQLQQPGAELVKPGASVKLSCKASGYTFSSYWMHWVKQRPGQVLEWIGEINPGNGHTNYNEKFKSKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARSFTTARGFAYWGQGTLVTVS 107 AA PAT REGION 1..107 note Synthetic variable light chain for 4B4-1-1 version 1 source 1..107 mol_type protein organism synthetic construct DIVMTQSPATQSVTPGDRVSLSCRASQTISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQDGHSFPPTFGGGTKLEIK 119 AA PAT REGION 1..119 note Synthetic variable heavy chain for 4B4-1-1 version 2 source 1..119 mol_type protein organism synthetic construct QVQLQQPGAELVKPGASVKLSCKASGYTFSSYWMHWVKQRPGQVLEWIGEINPGNGHTNYNEKFKSKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARSFTTARGFAYWGQGTLVTVSA 108 AA PAT REGION 1..108 note Synthetic variable light chain for 4B4-1-1 version 2 source 1..108 mol_type protein organism synthetic construct DIVMTQSPATQSVTPGDRVSLSCRASQTISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQDGHSFPPTFGGGTKLEIKR 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for H39E3-2 source 1..120 mol_type protein organism synthetic construct MDWTWRILFLVAAATGAHSEVQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMSWVRQAPGKGLEWVADIKNDGSYTNYAPSLTNRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARELT 109 AA PAT REGION 1..109 note Synthetic variable light chain for H39E3-2 source 1..109 mol_type protein organism synthetic construct MEAPAQLLFLLLLWLPDTTGDIVMTQSPDSLAVSLGERATINCKSSQSLLSSGNQKNYLWYQQKPGQPPKLLIYYASTRQSGVPDRFSGSGSGTDFTLTISSLQAEDVA 277 AA PAT REGION 1..277 note Synthetic human OX40 (Homo sapiens) source 1..277 mol_type protein organism synthetic construct MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI 272 AA PAT REGION 1..272 note Synthetic murine OX40 (Mus musculus) source 1..272 mol_type protein organism synthetic construct MYVWVQQPTALLLLGLTLGVTARRLNCVKHTYPSGHKCCRECQPGHGMVSRCDHTRDTLCHPCETGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTQDTVCRCRPGTQPRQDSGYKLGVDCVPCPPGHFSPGNNQACKPWTNCTLSGKQTRHPASDSLDAVCEDRSLLATLLWETQRPTFRPTTVQSTTVWPRTSELPSPPTLVTPEGPAFAVLLGLGLGLLAPLTVLLALYLLRKAWRLPNTPKPCWGNSFRTPIQEEHTDAHFTLAKI 451 AA PAT REGION 1..451 note Synthetic heavy chain for tavolixizumab source 1..451 mol_type protein organism synthetic construct QVQLQESGPGLVKPSQTLSLTCAVYGGSFSSGYWNWIRKHPGKGLEYIGYISYNGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYDGGHAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note Synthetic light chain for tavolixizumab source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGSALPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 118 AA PAT REGION 1..118 note Synthetic heavy chain variable region for tavolixizumab source 1..118 mol_type protein organism synthetic construct QVQLQESGPGLVKPSQTLSLTCAVYGGSFSSGYWNWIRKHPGKGLEYIGYISYNGITYHNPSLKSRITINRDTSKNQYSLQLNSVTPEDTAVYYCARYKYDYDGGHAMDYWGQGTLVT 108 AA PAT REGION 1..108 note Synthetic light chain variable region for tavolixizumab source 1..108 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGSALPWTFGQGTKVEIKR 9 AA PAT REGION 1..9 note Synthetic heavy chain CDR1 for tavolixizumab source 1..9 mol_type protein organism synthetic construct GSFSSGYWN 13 AA PAT REGION 1..13 note Synthetic heavy chain CDR2 for tavolixizumab source 1..13 mol_type protein organism synthetic construct YIGYISYNGITYH 14 AA PAT REGION 1..14 note Synthetic heavy chain CDR3 for tavolixizumab source 1..14 mol_type protein organism synthetic construct RYKYDYDGGHAMDY 8 AA PAT REGION 1..8 note Synthetic light chain CDR1 for tavolixizumab source 1..8 mol_type protein organism synthetic construct QDISNYLN 11 AA PAT REGION 1..11 note Synthetic light chain CDR2 for tavolixizumab source 1..11 mol_type protein organism synthetic construct LLIYYTSKLHS 8 AA PAT REGION 1..8 note Synthetic light chain CDR3 for tavolixizumab source 1..8 mol_type protein organism synthetic construct QQGSALPW 444 AA PAT REGION 1..444 note Synthetic heavy chain for 11D4 source 1..444 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIDYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARESGWYLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note Synthetic light chain for 11D4 source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 118 AA PAT REGION 1..118 note Synthetic heavy chain variable region for 11D4 source 1..118 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIDYADSVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCARESGWYLFDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note Synthetic light chain variable region for 11D4 source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPPTFGGGTKVEIK 5 AA PAT REGION 1..5 note Synthetic heavy chain CDR1 for 11D4 source 1..5 mol_type protein organism synthetic construct SYSMN 17 AA PAT REGION 1..17 note Synthetic heavy chain CDR2 for 11D4 source 1..17 mol_type protein organism synthetic construct YISSSSSTIDYADSVKG 9 AA PAT REGION 1..9 note Synthetic heavy chain CDR3 for 11D4 source 1..9 mol_type protein organism synthetic construct ESGWYLFDY 11 AA PAT REGION 1..11 note Synthetic light chain CDR1 for 11D4 source 1..11 mol_type protein organism synthetic construct RASQGISSWLA 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for 11D4 source 1..7 mol_type protein organism synthetic construct AASSLQS 9 AA PAT REGION 1..9 note Synthetic light chain CDR3 for 11D4 source 1..9 mol_type protein organism synthetic construct QQYNSYPPT 450 AA PAT REGION 1..450 note Synthetic heavy chain for 18D8 source 1..450 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDQSTADYYFYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 213 AA PAT REGION 1..213 note Synthetic light chain for 18D8 source 1..213 mol_type protein organism synthetic construct EIVVTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 124 AA PAT REGION 1..124 note Synthetic heavy chain variable region for 18D8 source 1..124 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSGISWNSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKDQSTADYYFYYGMDVWGQGTTVTVSS 106 AA PAT REGION 1..106 note Synthetic light chain variable region for 18D8 source 1..106 mol_type protein organism synthetic construct EIVVTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPTFGQGTKVEIK 5 AA PAT REGION 1..5 note Synthetic heavy chain CDR1 for 18D8 source 1..5 mol_type protein organism synthetic construct DYAMH 17 AA PAT REGION 1..17 note Synthetic heavy chain CDR2 for 18D8 source 1..17 mol_type protein organism synthetic construct GISWNSGSIGYADSVKG 15 AA PAT REGION 1..15 note Synthetic heavy chain CDR3 for 18D8 source 1..15 mol_type protein organism synthetic construct DQSTADYYFYYGMDV 11 AA PAT REGION 1..11 note Synthetic light chain CDR1 for 18D8 source 1..11 mol_type protein organism synthetic construct RASQSVSSYLA 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for 18D8 source 1..7 mol_type protein organism synthetic construct DASNRAT 8 AA PAT REGION 1..8 note Synthetic light chain CDR3 for 18D8 source 1..8 mol_type protein organism synthetic construct QQRSNWPT 120 AA PAT REGION 1..120 note Synthetic heavy chain variable region for Hu119-122 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASEYEFPSHDMSWVRQAPGKGLELVAAINSDGGSTYYPDTMERRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARHYDDYYAWFAYWGQGTMVTVSS 111 AA PAT REGION 1..111 note Synthetic light chain variable region for Hu119-122 source 1..111 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKSVSTSGYSYMHWYQQKPGQAPRLLIYLASNLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRELPLTFGGGTKVEIK 5 AA PAT REGION 1..5 note Synthetic heavy chain CDRl for Hu119-122 source 1..5 mol_type protein organism synthetic construct SHDMS 17 AA PAT REGION 1..17 note Synthetic heavy chain CDR2 for Hu119-122 source 1..17 mol_type protein organism synthetic construct AINSDGGSTYYPDTMER 11 AA PAT REGION 1..11 note Synthetic heavy chain CDR3 for Hu119-122 source 1..11 mol_type protein organism synthetic construct HYDDYYAWFAY 15 AA PAT REGION 1..15 note Synthetic light chain CDR1 for Hu119-122 source 1..15 mol_type protein organism synthetic construct RASKSVSTSGYSYMH 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for Hu119-122 source 1..7 mol_type protein organism synthetic construct LASNLES 9 AA PAT REGION 1..9 note Synthetic light chain CDR3 for Hu119-122 source 1..9 mol_type protein organism synthetic construct QHSRELPLT 122 AA PAT REGION 1..122 note Synthetic heavy chain variable region for Hu106-222 source 1..122 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYSMHWVRQAPGQGLKWMGWINTETGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCANPYYDYVSYYAMDYWGQGTTVTVSS 107 AA PAT REGION 1..107 note Synthetic light chain variable region for Hu106-222 source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYSASYLYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHYSTPRTFGQGTKLEIK 5 AA PAT REGION 1..5 note Synthetic heavy chain CDR1 for Hu106-222 source 1..5 mol_type protein organism synthetic construct DYSMH 17 AA PAT REGION 1..17 note Synthetic heavy chain CDR2 for Hu106-222 source 1..17 mol_type protein organism synthetic construct WINTETGEPTYADDFKG 13 AA PAT REGION 1..13 note Synthetic heavy chain CDR3 for Hu106-222 source 1..13 mol_type protein organism synthetic construct PYYDYVSYYAMDY 11 AA PAT REGION 1..11 note Synthetic light chain CDR1 for Hu106-222 source 1..11 mol_type protein organism synthetic construct KASQDVSTAVA 7 AA PAT REGION 1..7 note Synthetic light chain CDR2 for Hu106-222 source 1..7 mol_type protein organism synthetic construct SASYLYT 9 AA PAT REGION 1..9 note Synthetic light chain CDR3 for Hu106-222 source 1..9 mol_type protein organism synthetic construct QQHYSTPRT 183 AA PAT REGION 1..183 note Synthetic OX40L source 1..183 mol_type protein organism synthetic construct MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL 131 AA PAT REGION 1..131 note Synthetic OX40L soluble domain source 1..131 mol_type protein organism synthetic construct SHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL 128 AA PAT REGION 1..128 note Synthetic OX40L soluble domain (alternative) source 1..128 mol_type protein organism synthetic construct YPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for 008 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYTMNWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRYSQVHYALDYWGQGTLVTVS 108 AA PAT REGION 1..108 note Synthetic variable light chain for 008 source 1..108 mol_type protein organism synthetic construct DIVMTQSPDSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKAGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQYYNHPTTFGQGTK 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for 011 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGVVQPGRSLRLSCAASGFTFSDYTMNWVRQAPGKGLEWVSSISGGSTYYADSRKGRFTISRDNSKNTLYLQMNNLRAEDTAVYYCARDRYFRQQNAFDYWGQGTLVTVSSA 108 AA PAT REGION 1..108 note Synthetic variable light chain for 011 source 1..108 mol_type protein organism synthetic construct DIVMTQSPDSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKAGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQYYNHPTTFGQGTK 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for 021 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPRGSLRLSCAASGFTFSSYAMNWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRYITLPNALDYWGQGTLVTVS 108 AA PAT REGION 1..108 note Synthetic variable light chain for 021 source 1..108 mol_type protein organism synthetic construct DIQMTQSPVSLPVTPGEPASISCRSSQSLLHSNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQYKSNPPTFGQGTK 120 AA PAT REGION 1..120 note Synthetic variable heavy chain for 023 source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVHPGGSLRLSCAGSGFTFSSYAMHWVRQAPGKGLEWVSAIGTGGGTYYADSVMGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYDNVMGLYWFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Synthetic variable light chain for 023 source 1..108 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPAFGGGTKVEIKR 119 AA PAT REGION 1..119 note Synthetic heavy chain variable region source 1..119 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYINPYNDGTKYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCANYYGSSLSMDYWGQGTSVTVSS 108 AA PAT REGION 1..108 note Synthetic light chain variable region source 1..108 mol_type protein organism synthetic construct DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIKR 121 AA PAT REGION 1..121 note Synthetic heavy chain variable region source 1..121 mol_type protein organism synthetic construct EVQLQQSGPELVKPGASVKISCKTSGYTFKDYTMHWVKQSHGKSLEWIGGIYPNNGGSTYNQNFKDKATLTVDKSSSTAYMEFRSLTSEDSAVYYCARMGYHGPHLDFDVWGAGTTVTVSP 108 AA PAT REGION 1..108 note Synthetic light chain variable region source 1..108 mol_type protein organism synthetic construct DIVMTQSHKFMSTSLGDRVSITCKASQDVGAAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGGGSGTDFTLTISNVQSEDLTDYFCQQYINYPLTFGGGTKLEIKR 122 AA PAT REGION 1..122 note Synthetic heavy chain variable region of humanized antibody source 1..122 mol_type protein organism synthetic construct QIQLVQSGPELKKPGETVKISCKASGYTFTDYSMHWVKQAPGKGLKWMGWINTETGEPTYADDFKGRFAFSLETSASTAYLQINNLKNEDTATYFCANPYYDYVSYYAMDYWGHGTSVTVSS 122 AA PAT REGION 1..122 note Synthetic heavy chain variable region of humanized antibody source 1..122 mol_type protein organism synthetic construct QVQLVQSGSELKKPGASVKVSCKASGYTFTDYSMHWVRQAPGQGLKWMGWINTETGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCANPYYDYVSYYAMDYWGQGTTVTVSS 107 AA PAT REGION 1..107 note Synthetic light chain variable region of humanized antibody source 1..107 mol_type protein organism synthetic construct DIVMTQSHKFMSTSVRDRVSITCKASQDVSTAVAWYQQKPGQSPKLLIYSASYLYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTPRTFGGGTKLEIK 107 AA PAT REGION 1..107 note Synthetic light chain variable region of humanized antibody source 1..107 mol_type protein organism synthetic construct DIVMTQSHKFMSTSVRDRVSITCKASQDVSTAVAWYQQKPGQSPKLLIYSASYLYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQHYSTPRTFGGGTKLEIK 120 AA PAT REGION 1..120 note Synthetic heavy chain variable region of humanized antibody source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGESLKLSCESNEYEFPSHDMSWVRKTPEKRLELVAAINSDGGSTYYPDTMERRFIISRDNTKKTLYLQMSSLRSEDTALYYCARHYDDYYAWFAYWGQGTLVTVSA 120 AA PAT REGION 1..120 note Synthetic heavy chain variable region of humanized antibody source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASEYEFPSHDMSWVRQAPGKGLELVAAINSDGGSTYYPDTMERRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARHYDDYYAWFAYWGQGTMVTVSS 111 AA PAT REGION 1..111 note Synthetic light chain variable region of humanized antibody source 1..111 mol_type protein organism synthetic construct DIVLTQSPASLAVSLGQRATISCRASKSVSTSGYSYMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPLTFGAGTKLELK 111 AA PAT REGION 1..111 note Synthetic light chain variable region of humanized antibody source 1..111 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKSVSTSGYSYMHWYQQKPGQAPRLLIYLASNLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRELPLTFGGGTKVEIK 138 AA PAT REGION 1..138 note Synthetic heavy chain variable region source 1..138 mol_type protein organism synthetic construct MYLGLNYVFIVFLLNGVQSEVKLEESGGGLVQPGGSMKLSCAASGFTFSDAWMDWVRQSPEKGLEWVAEIRSKANNHATYYAESVNGRFTISRDDSKSSVYLQMNSLRAEDTGIYYCTWGEVFYFDYWGQGTTLTVSS 126 AA PAT REGION 1..126 note Synthetic light chain variable region source 1..126 mol_type protein organism synthetic construct MRPSIQFLGLLLFWLHGAQCDIQMTQSPSSLSASLGGKVTITCKSSQDINKYIAWYQHKPGKGPRLLIHYTSTLQPGIPSRFSGSGSGRDYSFSISNLEPEDIATYYCLQYDNLLTFGAGTKLELK 440 AA PAT REGION 1..440 note Synthetic nivolumab heavy chain source 1..440 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT REGION 1..214 note Synthetic nivolumab light chain source 1..214 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 113 AA PAT REGION 1..113 note Synthetic nivolumab variable heavy chain source 1..113 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS 107 AA PAT REGION 1..107 note Synthetic nivolumab variable light chain source 1..107 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK 5 AA PAT REGION 1..5 note Synthetic nivolumab heavy chain CDR1 source 1..5 mol_type protein organism synthetic construct NSGMH 17 AA PAT REGION 1..17 note Synthetic nivolumab heavy chain CDR2 source 1..17 mol_type protein organism synthetic construct VIWYDGSKRYYADSVKG 4 AA PAT REGION 1..4 note Synthetic nivolumab heavy chain CDR3 source 1..4 mol_type protein organism synthetic construct NDDY 11 AA PAT REGION 1..11 note Synthetic nivolumab light chain CDR1 source 1..11 mol_type protein organism synthetic construct RASQSVSSYLA 7 AA PAT REGION 1..7 note Synthetic nivolumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct DASNRAT 9 AA PAT REGION 1..9 note Synthetic nivolumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQSSNWPRT 447 AA PAT REGION 1..447 note Synthetic pembrolizumab heavy chain source 1..447 mol_type protein organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 218 AA PAT REGION 1..218 note Synthetic pembrolizumab light chain source 1..218 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT REGION 1..120 note Synthetic pembrolizumab variable heavy chain source 1..120 mol_type protein organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSS 111 AA PAT REGION 1..111 note Synthetic pembrolizumab variable light chain source 1..111 mol_type protein organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIK 5 AA PAT REGION 1..5 note Synthetic pembrolizumab heavy chain CDR1 source 1..5 mol_type protein organism synthetic construct NYYMY 16 AA PAT REGION 1..16 note Synthetic pembrolizumab heavy chain CDR2 source 1..16 mol_type protein organism synthetic construct GINPSNGGTNFNEKFK 11 AA PAT REGION 1..11 note Synthetic pembrolizumab heavy chain CDR3 source 1..11 mol_type protein organism synthetic construct RDYRFDMGFDY 15 AA PAT REGION 1..15 note Synthetic pembrolizumab light chain CDR1 source 1..15 mol_type protein organism synthetic construct RASKGVSTSGYSYLH 7 AA PAT REGION 1..7 note Synthetic pembrolizumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct LASYLES 9 AA PAT REGION 1..9 note Synthetic pembrolizumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QHSRDLPLT 451 AA PAT REGION 1..451 note Synthetic durvalumab heavy chain source 1..451 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPASIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 265 AA PAT REGION 1..265 note Synthetic durvalumab light chain source 1..265 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANEIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 121 AA PAT REGION 1..121 note Synthetic durvalumab variable heavy chain source 1..121 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Synthetic durvalumab variable light chain source 1..108 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQRVSSSYLAWYQQKPGQAPRLLIYDASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSLPWTFGQGTKVEIK 5 AA PAT REGION 1..5 note Synthetic durvalumab heavy chain CDR1 source 1..5 mol_type protein organism synthetic construct RYWMS 17 AA PAT REGION 1..17 note Synthetic durvalumab heavy chain CDR2 source 1..17 mol_type protein organism synthetic construct NIKQDGSEKYYVDSVKG 12 AA PAT REGION 1..12 note Synthetic durvalumab heavy chain CDR3 source 1..12 mol_type protein organism synthetic construct EGGWFGELAFDY 12 AA PAT REGION 1..12 note Synthetic durvalumab light chain CDR1 source 1..12 mol_type protein organism synthetic construct RASQRVSSSYLA 7 AA PAT REGION 1..7 note Synthetic durvalumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct DASSRAT 9 AA PAT REGION 1..9 note Synthetic durvalumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQYGSLPWT 450 AA PAT REGION 1..450 note Synthetic avelumab heavy chain source 1..450 mol_type protein organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT REGION 1..216 note Synthetic avelumab light chain source 1..216 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 120 AA PAT REGION 1..120 note Synthetic avelumab variable heavy chain source 1..120 mol_type protein organism synthetic construct EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYIMMWVRQAPGKGLEWVSSIYPSGGITFYADTVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARIKLGTVTTVDYWGQGTLVTVSS 110 AA PAT REGION 1..110 note Synthetic avelumab variable light chain source 1..110 mol_type protein organism synthetic construct QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSSTRVFGTGTKVTVL 5 AA PAT REGION 1..5 note Synthetic avelumab heavy chain CDR1 source 1..5 mol_type protein organism synthetic construct SYIMM 17 AA PAT REGION 1..17 note Synthetic avelumab heavy chain CDR2 source 1..17 mol_type protein organism synthetic construct SIYPSGGITFYADTVKG 11 AA PAT REGION 1..11 note Synthetic avelumab heavy chain CDR3 source 1..11 mol_type protein organism synthetic construct IKLGTVTTVDY 14 AA PAT REGION 1..14 note Synthetic avelumab light chain CDR1 source 1..14 mol_type protein organism synthetic construct TGTSSDVGGYNYVS 7 AA PAT REGION 1..7 note Synthetic avelumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct DVSNRPS 10 AA PAT REGION 1..10 note Synthetic avelumab light chain CDR3 source 1..10 mol_type protein organism synthetic construct SSYTSSSTRV 448 AA PAT REGION 1..448 note Synthetic atezolizumab heavy chain source 1..448 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note Synthetic atezolizumab light chain source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 118 AA PAT REGION 1..118 note Synthetic atezolizumab variable heavy chain source 1..118 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA 108 AA PAT REGION 1..108 note Synthetic atezolizumab variable light chain source 1..108 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKR 10 AA PAT REGION 1..10 note Synthetic atezolizumab heavy chain CDR1 source 1..10 mol_type protein organism synthetic construct GFTFSDSWIH 18 AA PAT REGION 1..18 note Synthetic atezolizumab heavy chain CDR2 source 1..18 mol_type protein organism synthetic construct AWISPYGGSTYYADSVKG 9 AA PAT REGION 1..9 note Synthetic atezolizumab heavy chain CDR3 source 1..9 mol_type protein organism synthetic construct RHWPGGFDY 11 AA PAT REGION 1..11 note Synthetic atezolizumab light chain CDR1 source 1..11 mol_type protein organism synthetic construct RASQDVSTAVA 7 AA PAT REGION 1..7 note Synthetic atezolizumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct SASFLYS 9 AA PAT REGION 1..9 note Synthetic atezolizumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQYLYHPAT 225 AA PAT REGION 1..225 note Synthetic ipilimumab heavy chain source 1..225 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH 215 AA PAT REGION 1..215 note Synthetic ipilimumab light chain source 1..215 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 118 AA PAT REGION 1..118 note Synthetic ipilimumab variable heavy chain source 1..118 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 108 AA PAT REGION 1..108 note Synthetic ipilimumab variable light chain source 1..108 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK 8 AA PAT REGION 1..8 note Synthetic ipilimumab heavy chain CDR1 source 1..8 mol_type protein organism synthetic construct GFTFSSYT 10 AA PAT REGION 1..10 note Synthetic ipilimumab heavy chain CDR2 source 1..10 mol_type protein organism synthetic construct TFISYDGNNK 11 AA PAT REGION 1..11 note Synthetic ipilimumab heavy chain CDR3 source 1..11 mol_type protein organism synthetic construct ARTGWLGPFDY 7 AA PAT REGION 1..7 note Synthetic ipilimumab light chain CDR1 source 1..7 mol_type protein organism synthetic construct QSVGSSY 000 9 AA PAT REGION 1..9 note Synthetic ipilimumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQYGSSPWT 451 AA PAT REGION 1..451 note Synthetic tremelimumab heavy chain source 1..451 mol_type protein organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note Synthetic tremelimumab light chain source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 167 AA PAT REGION 1..167 note Synthetic tremelimumab variable heavy chain source 1..167 mol_type protein organism synthetic construct GVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVH 139 AA PAT REGION 1..139 note Synthetic tremelimumab variable light chain source 1..139 mol_type protein organism synthetic construct PSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKV 10 AA PAT REGION 1..10 note Synthetic tremelimumab heavy chain CDR1 source 1..10 mol_type protein organism synthetic construct GFTFSSYGMH 15 AA PAT REGION 1..15 note Synthetic tremelimumab heavy chain CDR2 source 1..15 mol_type protein organism synthetic construct VIWYDGSNKYYADSV 16 AA PAT REGION 1..16 note Synthetic tremelimumab heavy chain CDR3 source 1..16 mol_type protein organism synthetic construct DPRGATLYYYYYGMDV 11 AA PAT REGION 1..11 note Synthetic tremelimumab light chain CDR1 source 1..11 mol_type protein organism synthetic construct RASQSINSYLD 7 AA PAT REGION 1..7 note Synthetic tremelimumab light chain CDR2 source 1..7 mol_type protein organism synthetic construct AASSLQS 9 AA PAT REGION 1..9 note Synthetic tremelimumab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQYYSTPFT 448 AA PAT REGION 1..448 note Synthetic zalifrelimab heavy chain source 1..448 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVGLMGPFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT REGION 1..214 note Synthetic zalifrelimab light chain source 1..214 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSRYLGWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTITRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 118 AA PAT REGION 1..118 note Synthetic zalifrelimab variable heavy chain source 1..118 mol_type protein organism synthetic construct EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARVGLMGPFDIWGQGTMVTVSS 107 AA PAT REGION 1..107 note Synthetic zalifrelimab variable light chain source 1..107 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSRYLGWYQQKPGQAPRLLIYGASTRATGIPDRFSGSGSGTDFTLTITRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK 8 AA PAT REGION 1..8 note Synthetic zalifrelimab heavy chain CDR1 source 1..8 mol_type protein organism synthetic construct GFTFSSYS 8 AA PAT REGION 1..8 note Synthetic zalifrelimab heavy chain CDR2 source 1..8 mol_type protein organism synthetic construct ISSSSSYI 11 AA PAT REGION 1..11 note Synthetic zalifrelimab heavy chain CDR3 source 1..11 mol_type protein organism synthetic construct ARVGLMGPFDI 6 AA PAT REGION 1..6 note Synthetic zalifrelimab light chain CDR1 source 1..6 mol_type protein organism synthetic construct QSVSRY 000 9 AA PAT REGION 1..9 note Synthetic zalifrelimab light chain CDR3 source 1..9 mol_type protein organism synthetic construct QQYGSSPWT 199 AA PAT source 1..199 mol_type protein organism synthetic construct EGIKSNISLLKDELRGQISHISHEYLSLIDLAFDSKQNRLFEMKVLELLVNEYGFKGRHLGGSRKPDGIVYSTTLEDNFGIIVDTKAYSEGYSLPISQADEMERYVRENSNRDEEVNPNKWWENFSEEVKKYYFVFISGSFKGKFEEQLRRLSMTTGVNGSAVNVVNLLLGAEKIRSGEMTIEELERAMFNNSEFILKY 594 AA PAT source 1..594 mol_type protein organism synthetic construct MGSSLDDEHILSALLQSDDELVGEDSDSEISDHVSEDDVQSDTEEAFIDEVHEVQPTSSGSEILDEQNVIEQPGSSLASNRILTLPQRTIRGKNKHCWSTSKSTRRSRVSALNIVRSQRGPTRMCRNIYDPLLCFKLFFTDEIISEIVKWTNAEISLKRRESMTGATFRDTNEDEIYAFFGILVMTAVRKDNHMSTDDLFDRSLSMVYVSVMSRDRFDFLIRCLRMDDKSIRPTLRENDVFTPVRKIWDLFIHQCIQNYTPGAHLTIDEQLLGFRGRCPFRMYIPNKPSKYGIKILMMCDSGTKYMINGMPYLGRGTQTNGVPLGEYYVKELSKPVHGSCRNITCDNWFTSIPLAKNLLQEPYKLTIVGTVRSNKREIPEVLKNSRSRPVGTSMFCFDGPLTLVSYKPKPAKMVYLLSSCDEDASINESTGKPQMVMYYNQTKGGVDTLDQMCSVMTCSRKTNRWPMALLYGMINIACINSFIIYSHNVSSKGEKVQSRKKFMRNLYMSLTSSFMRKRLEAPTLKRYLRDNISNILPNEVPGTSDDSTEEPVMKKRTYCTYCPSKIRRKANASCKKCKKVICREHNIDMCQSCF 338 AA PAT source 1..338 mol_type protein organism synthetic construct MGKSKEISQDLRKKIVDLHKSGSSLGAISKRLKVPRSSVQTIVRKYKHHGTTQPSYRSGRRRVLSPRDERTLVRKVQINPRTTAKDLVKMLEETGTKVSISTVKRVLYRHNLKGRSARKKPLLQNRHKKARLRFATAHGDKDRTFWRNVLWSDETKIELFGHNDHRYVWRKKGEACKPKNTIPTVKHGGGSIMLWGCFAAGGTGALHKIDGIMRKENYVDILKQHLKTSVRKLKLGRKVFQMDNDPKHTSKWAKWLKDNKVKVLEWPSQSPDLNPIENLWAELKKRVRARRPTNLTQLHQLCQEEWAKIHPTYCGKLVEGYPKRLTQVKQFKGNATKY 339 AA PAT source 1..339 mol_type protein organism synthetic construct MGKSKEISQDLRKRIVDLHKSGSSLGAISKRLAVPRSSVQTIVRKYKHHGTTQPSYRSGRRRVLSPRDERTLVRKVQINPRTTAKDLVKMLEETGTKVSISTVKRVLYRHNLKGHSARKKPLLQNRHKKARLRFATAHGDKDRTFWRNVLWSDETKIELFGHNDHRYVWRKKGEACKPKNTIPTVKHGGGSIMLWGCFAAGGTGALHKIDGIMDAVQYVDILKQHLKTSVRKLKLGRKWVFQHDNDPKHTSKWAKWLKDNKVKVLEWPSQSPDLNPIENLWAELKKRVRARRPTNLTQLHQLCQEEWAKIHPNYCGKLVEGYPKRLTQVKQFKGNATKY