A24006-WO JP 2023-160157 2023-09-25 Astellas Pharma Inc. 抗MerTKアゴニスト抗体、抗MerTK二重特異性抗体、及びその使用 Anti-MerTK agonist antibody, anti-MerTK bispecific antibody and use thereof 70 5 AA PAT source 1..5 mol_type protein note tA3-20_tA3-20.5_HC_CDR1_aa organism synthetic construct SYAIS 17 AA PAT source 1..17 mol_type protein note tA3-20_tA3-20.5_HC_CDR2_aa organism synthetic construct GIIPIFGPAKHAQKFQG 10 AA PAT source 1..10 mol_type protein note tA3-20_tA3-20.5_HC_CDR3_aa organism synthetic construct LVGATGWFDP 13 AA PAT source 1..13 mol_type protein note tA3-20_tA3-20.5_LC_CDR1_aa organism synthetic construct TRSSGSIATNYVQ 7 AA PAT source 1..7 mol_type protein note tA3-20_tA3-20.5_LC_CDR2_aa organism synthetic construct EDNQRPS 9 AA PAT source 1..9 mol_type protein note tA3-20_tA3-20.5_LC_CDR3_aa organism synthetic construct QSYDSSNVV 1347 DNA PAT source 1..1347 mol_type other DNA note tA3-20_tA3-20.5_HC_DNA organism synthetic construct caggtgcagctggttcagtctggcgccgaagtgaagaaacctggctcctccgtgaaggtgtcctgcaaggcttctggcggcaccttcaactcctacgccatctcttggatgagacaggcccctggacagggccttgaatggatgggaggcatcatccccatcttcggccctgctaagcacgcccagaaattccagggcagagtgaccatcaccgccgacaagtctacctccaccgtgtacatggaactgtccagcctgagatccgaggacaccgccgtgtactactgtgctagactcgtgggcgctaccggatggttcgatccttggggacagggcacactggtcaccgtgtcctctgcttctaccaagggacccagcgtgttccctctggctcctagctctaagtccacctccggtggaacagctgctctgggctgtctggtcaaggactacttccctgagcctgtgaccgtgtcttggaactctggcgctctgacatccggcgtgcacacctttccagctgtgctgcaatcctccggcctgtactctctgtcctccgtcgtgaccgtgccttctagctctctgggcacccagacctacatctgcaatgtgaaccacaagccttccaacaccaaggtggacaagaaggtggaacccaagtcctgcgacaagacccacacctgtcctccatgtcctgctccagaagctgcaggcggcccttccgtgtttctgttccctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcacgaggacccagaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaactccacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggcactgcctgccggcatcgaaaagaccatctccaaggctaagggccagcctcgggaaccccaggtttacacattgcctccatctcgggacgagctgaccaagaaccaggtgtccctgacctgtctcgtgaagggcttctacccctccgatatcgccgtggaatgggagtccaatggccagccagagaacaactacaagacaacccctcctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtccagatggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaatcactacacacagaagtccctgtctctgtcccctggcaag 449 AA PAT source 1..449 mol_type protein note tA3-20_tA3-20.5_HC_aa organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGGTFNSYAISWMRQAPGQGLEWMGGIIPIFGPAKHAQKFQGRVTITADKSTSTVYMELSSLRSEDTAVYYCARLVGATGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 645 DNA PAT source 1..645 mol_type other DNA note tA3-20_LC_DNA organism synthetic construct ttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgaacatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 215 AA PAT source 1..215 mol_type protein note tA3-20_LC_aa organism synthetic construct FMLTQPHSVSESPGKTVNISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 645 DNA PAT source 1..645 mol_type other DNA note tA3-20.1_LC_DNA organism synthetic construct ttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgaccatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 215 AA PAT source 1..215 mol_type protein note tA3-20.1_LC_aa organism synthetic construct FMLTQPHSVSESPGKTVTISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 645 DNA PAT source 1..645 mol_type other DNA note tA3-20.2_LC_DNA organism synthetic construct ttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgagcatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 215 AA PAT source 1..215 mol_type protein note tA3-20.2_LC_aa organism synthetic construct FMLTQPHSVSESPGKTVSISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 648 DNA PAT source 1..648 mol_type other DNA note tA3-20.3_LC_DNA organism synthetic construct aacttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgaacatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 216 AA PAT source 1..216 mol_type protein note tA3-20.3_LC_aa organism synthetic construct NFMLTQPHSVSESPGKTVNISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 648 DNA PAT source 1..648 mol_type other DNA note tA3-20.4_LC_DNA organism synthetic construct aacttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgaccatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 216 AA PAT source 1..216 mol_type protein note tA3-20.4_LC_aa organism synthetic construct NFMLTQPHSVSESPGKTVTISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 648 DNA PAT source 1..648 mol_type other DNA note tA3-20.5_LC_DNA organism synthetic construct aacttcatgctgacccagcctcactccgtgtctgagtctccaggcaagaccgtgagcatcagctgcaccagatcctccggctctatcgccaccaactacgtgcagtggtatcagcagaggcccggctcctctcctaccaccgtgatctacgaggacaaccagaggccttctggcgtgcccgatagattttccggctccatcgactcctccagcaactccgcttctctgaccatctccggcctgaaaaccgaggacgaggccgtgtaccactgccagtcctacgactcctctaacgtggtgtttggcggaggcaccaagctgacagtgctgggacaacctaaggccgctccttccgtgacactgttccctccatcctccgaggaactgcaggccaacaaggctaccctcgtgtgcctgatctccgacttttaccctggcgctgtgaccgtggcctggaaggctgatagttctcctgtgaaggccggcgtggaaaccaccacaccttccaagcagtccaacaacaaatacgccgcctcctcctacctgtctctgacccctgaacagtggaagtcccaccggtcctacagctgccaagtgacccatgagggctccaccgtggaaaagaccgtggctcctaccgagtgctcc 216 AA PAT source 1..216 mol_type protein note tA3-20.5_LC_aa organism synthetic construct NFMLTQPHSVSESPGKTVSISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 18 DNA PAT source 1..18 mol_type other DNA note Histag_DNA organism synthetic construct catcatcatcatcatcac 6 AA PAT source 1..6 mol_type protein note Histag_aa organism synthetic construct HHHHHH 1344 DNA PAT source 1..1344 mol_type other DNA note MTK201_HC_DNA organism synthetic construct caggtccagctgagacagtctggccctggactggttcagccttctcagtccctgtccatcacctgtaccgtgtccggcttctccctgtctaactacggcctgcactgggtccgacagtctccaggcaaaggactggaatggctgggagtgatttggagcggcggcatcaccgattacaacgccgccttcatctcccggctgagcatcatcaaggacaactctcggagccaggtgttcttcaagatgaactccctgcaggccgacgacaccgccatctactactgtgccagaaagggccacgatccttacgccatggatttctggggccagggcacctctgtgaccgtgtctagcgcttctaccaagggacccagcgtgttccctctggctccttccagcaagtctacctctggcggaacagctgctctgggctgcctggtcaaggactactttcctgagcctgtgacagtgtcctggaactctggcgctctgacatccggcgtgcacacctttccagctgtgctgcaatcctccggcctgtactctctgtcctccgtcgtgaccgtgccttctagctctctgggcacccagacctacatctgcaatgtgaaccacaagccttccaacaccaaggtggacaagaaggtggaacccaagtcctgcgacaagacccacacctgtcctccatgtcctgctccagaagctgctggcggcccttccgtgtttctgttccctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaactccacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgccggcatcgaaaagaccatctctaaggccaagggccagcctcgggaaccccaggtttacacattgcctccatctcgggacgagctgaccaagaaccaggtgtccctgacctgtctcgtgaagggcttctacccctccgatatcgccgtggaatgggagtctaatggccagcctgagaacaactacaagacaacccctcctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtccagatggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaatcactacacccagaagtctctgtctctgtcccctggcaag 448 AA PAT source 1..448 mol_type protein note MTK201_HC_aa organism synthetic construct QVQLRQSGPGLVQPSQSLSITCTVSGFSLSNYGLHWVRQSPGKGLEWLGVIWSGGITDYNAAFISRLSIIKDNSRSQVFFKMNSLQADDTAIYYCARKGHDPYAMDFWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 645 DNA PAT source 1..645 mol_type other DNA note MTK201_LC_DNA organism synthetic construct cagatcgtgctgacccagtctcctcctatcatgtccgcctttctcggcgagcgcgtgacaatgacctgtaccgcctcttccagcgtgtcctcctcttacctgcactggtacagacagatgcccggcagctctcccaagctgtggatctacgacacctccaacctggcctctggcgtgccagctagattttccggctctggctctggcacctcctacagcctgaccatctcctccatggaagccgaggatgccgccacctactactgccaccagtaccaccactctccatacacctttggcggaggcaccaagctggaaatcaagcggacagtggccgctccttccgtgttcatcttcccaccttccgacgagcagctgaagtctggcacagcctctgtcgtgtgcctgctgaacaacttctaccctcgggaagccaaggtgcagtggaaggtggacaatgccctgcagtccggcaactcccaagagtctgtgaccgagcaggactccaaggactctacctactctctgtcctccacactgaccctgtccaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccatcagggcctgtctagccctgtgaccaagtctttcaaccggggcgagtgc 215 AA PAT source 1..215 mol_type protein note MTK201_LC_aa organism synthetic construct QIVLTQSPPIMSAFLGERVTMTCTASSSVSSSYLHWYRQMPGSSPKLWIYDTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCHQYHHSPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein note 371M_HC_CDR1_aa organism synthetic construct SYAMS 17 AA PAT source 1..17 mol_type protein note 371M_HC_CDR2_aa organism synthetic construct AISGSGGSTYYADSVKG 10 AA PAT source 1..10 mol_type protein note 371M_HC_CDR3_aa organism synthetic construct GTRTNWYFDL 15 AA PAT source 1..15 mol_type protein note 371M_LC_CDR1_aa organism synthetic construct SCSGSRSNIGSNTVN 7 AA PAT source 1..7 mol_type protein note 371M_LC_CDR2_aa organism synthetic construct SNNQRPS 11 AA PAT source 1..11 mol_type protein note 371M_LC_CDR3_aa organism synthetic construct AAWDDSLYGPV 1347 DNA PAT source 1..1347 mol_type other DNA note tA3-20.3_mouse_HC organism synthetic construct caggtgcagctggtgcagtctggggctgaggtgaagaagcctgggtcctcggtgaaggtctcctgcaaggcttctggaggcaccttcaacagctatgctatcagctggatgcgacaggcccctggacaaggacttgagtggatgggagggatcatccctatctttggtccagcaaaacacgcacagaagttccagggcagagtcacgattaccgcggacaaatccacgagcacagtgtacatggagttgagcagcctgagatctgaggacacggccgtgtattattgtgcgagactagtgggagctactggctggttcgacccctggggccagggaaccctggtcaccgtctcctcagctaagaccaccgctcctagcgtgtaccctctggctcctgtgtgtggcgataccaccggatcttccgtgacactgggctgtctggtcaagggctacttccccgaacctgtgacactgacctggaactccggctctctgtctagcggcgtgcacacctttccagccgtgctgcagtctgacctgtacaccctgtcctctagcgtgaccgtgacctcctctacctggcctagccagtccatcacctgtaacgtggcccatcctgcctccagcaccaaggtggacaagaagatcgagcctcggggccctaccatcaagccttgtcctccatgcaagtgccccgctcctaatgctgctggtggcccttccgtgttcatcttcccacctaagatcaaggacgtgctgatgatctccctgtctcctatcgtgacctgcgtggtggtggacgtgtccgaggatgatcctgacgtgcagatcagttggttcgtgaacaacgtggaagtgcacaccgctcagacccagacacacagagaggactacaacagcaccctgagagtggtgtctgccctgcctatccagcatcaggactggatgtccggcaaagagttcaagtgcaaagtgaacaacaaggacctggccgctcctatcgagcggaccatctctaagcctaagggctctgtcagggcccctcaggtgtacgttttgccacctcctgagaaagagatgaccaagaaacaggtgtccctgacctgcctcgtgaaggacttcatgcccgaggacatctacgtggaatggaccaacaacggcaagaccgagctgaactacaagaacaccgagcctgtgctgaagtccgacggctcctacttcatgtactccaagctgaccgtcgagaagaagaactgggtcgagagaaactcctactcctgctccgtggtgcacgagggcctgcacaatcaccacaccaccaagtccttctctcggacccctggaaag 449 AA PAT source 1..449 mol_type protein note tA3-20.3_mouse_HC organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGGTFNSYAISWMRQAPGQGLEWMGGIIPIFGPAKHAQKFQGRVTITADKSTSTVYMELSSLRSEDTAVYYCARLVGATGWFDPWGQGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNAAGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLAAPIERTISKPKGSVRAPQVYVLPPPEKEMTKKQVSLTCLVKDFMPEDIYVEWTNNGKTELNYKNTEPVLKSDGSYFMYSKLTVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 648 DNA PAT source 1..648 mol_type other DNA note tA3-20.3_mouse_LC organism synthetic construct aattttatgctgactcagccccactctgtgtcggagtctccggggaagacggtaaacatctcctgcacccgcagcagtggcagcattgccaccaactatgtgcagtggtaccagcagcgccccggcagttcccccaccactgtgatctatgaggataaccaaagaccctctggggtccctgatcggttctctggctccatcgacagctcctccaactctgcctccctcaccatctctggactgaagactgaggacgaggctgtctatcactgtcagtcttatgatagcagcaatgtggtattcggcggagggaccaagctgaccgtcctaggccagcctaagtcctctccttccgtgactctgttccctccatcctccgaggaactggaaacaaacaaggctaccctcgtgtgcaccatcaccgacttctatcctggcgtggtcaccgtggactggaaggtggacggaacccctgtgacacaaggcatggaaaccacacagccctccaagcagtccaacaacaagtacatggcctccagctatctgaccctgaccgctagagcttgggagagacactcctcctacagctgccaagtgacccacgagggccacaccgtggaaaagtctctgtctagagccgactgctcc 216 AA PAT source 1..216 mol_type protein note tA3-20.3_mouse_LC organism synthetic construct NFMLTQPHSVSESPGKTVNISCTRSSGSIATNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEAVYHCQSYDSSNVVFGGGTKLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS 1434 DNA PAT source 1..1434 mol_type other DNA note 371M_scFv_mouse Fc organism synthetic construct gaagtgcagctggttgaatctggcggcggagttgttcagcctggcggatctctgagactgtcttgtgccgcctccggcttcaccttctcctcttacgctatgtcctgggtccgacaggcccctggcaaatgtctggaatgggtgtccgccatctctggctctggcggctctacctactacgccgactctgtgaagggcagattcaccatcagccgggacaactccaagaacaccctgtacctgcagatgaactccctgagagccgaggacaccgccgtgtactactgtgctaagggcacccgcaccaactggtacttcgatctgtggggcagaggcaccctggtcacagtttctagcggaggcggaggatcaggtggcggtggatctggcggtggcggatcctcttatgagctgacccaacctccttccgcctctggcacacctggacagagagtgaccatctcctgctccggctctcggtccaacatcggctctaacaccgtgaactggtatcagcaggtccccggcacagctcccaagctgctgatctactccaacaaccagcggccttctggcgtgcccgatagattcagcggctctaagtctggcacctctgccagcctggctatcagtggactgcagagcgaggatgaggctgagtactactgcgccgcctgggacgattctctgtacggccctgtgtttggctgtggcacccagctgacagtgctgggagaacctaggggccctaccatcaagccttgtcctccatgcaagtgccccgctcctaatgctgctggtggcccttccgtgttcatcttcccacctaagatcaaggacgtgctgatgatctccctgtctcctatcgtgacctgcgtggtggtggacgtgtccgaggatgatcctgacgtgcagatcagttggttcgtgaacaacgtggaagtgcacaccgctcagacccagacacacagagaggactacaacagcaccctgagagtggtgtctgccctgcctatccagcaccaggattggatgtccggcaaagagttcaagtgcaaagtgaacaacaaggacctggccgctcctatcgagcggaccatctctaagcctaagggctctgtcagggccccacaggtgtacgttttgcctccacctgaggaagagatgaccaagaaacaggtgtccctgacctgcctggtcaaggacttcatgcccgaggacatctacgtggaatggaccaacaacggcaagaccgagctgaattacaagaacacagagcccgtgctggactccgacggctcctacttcatgtactccgagctgaccgtcgagaagaagaactgggtcgagagaaactcctactcctgcagcgtggtgcacgagggcctgcacaatcaccacaccaccgacagcttcagcagaaccccaggcaag 478 AA PAT source 1..478 mol_type protein note 371M_scFv_mouse Fc organism synthetic construct EVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKCLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGTRTNWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSSYELTQPPSASGTPGQRVTISCSGSRSNIGSNTVNWYQQVPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAEYYCAAWDDSLYGPVFGCGTQLTVLGEPRGPTIKPCPPCKCPAPNAAGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLAAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVSLTCLVKDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSELTVEKKNWVERNSYSCSVVHEGLHNHHTTDSFSRTPGK 217 AA PAT source 1..217 mol_type protein note tA3-20_Fc organism synthetic construct APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 217 AA PAT source 1..217 mol_type protein note tA3-20_human 371M_Fc_knob organism synthetic construct APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 217 AA PAT source 1..217 mol_type protein note tA3-20_human 371M_Fc_hole organism synthetic construct APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 15 AA PAT source 1..15 mol_type protein note Hinge organism synthetic construct EPKSCDKTHTCPPCP 245 AA PAT source 1..245 mol_type protein note 371M_scFv organism synthetic construct EVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKCLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGTRTNWYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSSYELTQPPSASGTPGQRVTISCSGSRSNIGSNTVNWYQQVPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAEYYCAAWDDSLYGPVFGCGTQLTVLG 449 AA PAT source 1..449 mol_type protein note 371M_HC_control organism synthetic construct EVQLVESGGGVVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGTRTNWYFDLWGRGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK 216 AA PAT source 1..216 mol_type protein note 371M_LC_control organism synthetic construct SYELTQPPSASGTPGQRVTISCSGSRSNIGSNTVNWYQQVPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAEYYCAAWDDSLYGPVFGGGTQLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS 4 AA PAT source 1..4 mol_type protein note GS_linker_1 organism synthetic construct GGGS 4 AA PAT source 1..4 mol_type protein note GS_linker_2 organism synthetic construct SGGG 5 AA PAT source 1..5 mol_type protein note GS_linker_3 organism synthetic construct GGGGS 5 AA PAT source 1..5 mol_type protein note GS_linker_4 organism synthetic construct SGGGG 6 AA PAT source 1..6 mol_type protein note GS_linker_5 organism synthetic construct GGGGGS 6 AA PAT source 1..6 mol_type protein note GS_linker_6 organism synthetic construct SGGGGG 7 AA PAT source 1..7 mol_type protein note GS_linker_7 organism synthetic construct GGGGGGS 7 AA PAT source 1..7 mol_type protein note GS_linker_8 organism synthetic construct SGGGGGG 15 AA PAT source 1..15 mol_type protein note GS_linker_9 organism synthetic construct GGGGSGGGGSGGGGS 5 AA PAT source 1..5 mol_type protein note GS_linker_10 organism synthetic construct GKPGS 1359 DNA PAT source 1..1359 mol_type other DNA note 2A4-VH_CK_Fc_knob organism synthetic construct gaggttcaacttgttgaaagtggcggaagattagtgcagcccaaaggctccctcaaactgtcttgtgctgcaagtggctttacgtttaacacctatgccatgtattggatccggcaggcaccaggtaaagggttagaatgggtggcacgaatccgcagtaagtcaaataactacgccatctactacgccgacagcgttaaagataggttcaccatcttccgcgacgacagccagagcatgctgtatctccagatgaacaacctgaagacggaggataccgctatgtactactgcgtcaggccctactcagacagtttcgcctattggggccagggtactcttgtaactgtctcctccgctagcgtggcggccccatctgtatttattttccctccatcagatgagcagcttaagtcaggaaccgcttccgtggtgtgcctgctaaacaacttctatccccgggaggcaaaggtccaatggaaagtagacaatgccctccagagcgggaactctcaagaatctgtgacagagcaagatagtaaggattcgacctactccctgagctccacacttacactcagcaaagcagactacgagaagcacaaagtctacgcctgcgaggttacacaccagggcctgagtagccctgtcacaaaatcatttaaccggggcgaatgcgacaagactcacacatgtcctccatgtcctgctccagaagctgctggtggaccatctgtatttctctttcctcccaagcccaaggacacacttatgatttcacgaacacccgaagtgacctgtgtggtggtcgatgtgtcccatgaggatcctgaggtcaaattcaactggtacgtggacggcgtggaggttcataatgctaaaactaagcccagggaggagcagtataatagcacttatcgcgtggtctcggtgctcactgttttgcatcaggactggctgaacgggaaagaatataagtgtaaggtgagcaataaggccctgcctgctggaatagagaagacaattagcaaggccaaggggcagccaagagaacctcaagtatataccctcccgccctctagagatgaattgactaagaatcaggtgagcctgtggtgcctggtgaaaggattttatcccagcgacatcgctgtggagtgggaaagtaacggccagcctgaaaataactacaagaccactccgcccgtgctggattctgatggttctttctttctgtactccaagctgaccgtggacaagtctcgttggcagcagggcaatgtcttctcatgctctgtgatgcacgaggcactacacaatcactacacccagaagtccctgtccttgtctccaggaaaa 453 AA PAT source 1..453 mol_type protein note 2A4-VH_CK_Fc_knob organism synthetic construct EVQLVESGGRLVQPKGSLKLSCAASGFTFNTYAMYWIRQAPGKGLEWVARIRSKSNNYAIYYADSVKDRFTIFRDDSQSMLYLQMNNLKTEDTAMYYCVRPYSDSFAYWGQGTLVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 651 DNA PAT source 1..651 mol_type other DNA note 2A4-VK_CH1 organism synthetic construct gacgttgttatgacacaaactccactctctttaccagtctctctaggggatcaggccagcattagctgccgatcttctcagagtctggtccattcaaccggaaatacctatctgcactggtacctccagaagcccggtcaatctccaaaactgctgatctacaaggtcagcaaccgcttcagcggcgtaccagatagattttccggctccggcagcggcacatacttcacactcaaaattagcagggtcgaggcagaagatcttggtgtgtatttctgcagccagtccacccacgtccctttcacttttggaggtggaacgaagctcgagatcaagagctccgctagcacaaaaggcccttcagtatttcctctggcccctagtagcaagtccacaagtggcggcacagcagctctgggatgtctcgttaaagactatttccccgaacccgtcaccgtgtcctggaactctggggctctgacttctggagttcatacctttcccgctgtgttgcagtcgtccgggctgtacagtctgtcttcagtggtgactgtgcccagttcttcactggggactcagacatacatctgcaacgtgaaccacaagccctcaaataccaaggtggacaagaaggtggagccgaaaagttgt 217 AA PAT source 1..217 mol_type protein note 2A4-VK_CH1 organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSTGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTYFTLKISRVEAEDLGVYFCSQSTHVPFTFGGGTKLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 1347 DNA PAT source 1..1347 mol_type other DNA note tA3-20_HC_hole organism synthetic construct caggtgcagctggttcagtctggcgccgaagtgaagaaacctggctcctccgtgaaggtgtcctgcaaggcttctggcggcaccttcaactcctacgccatctcttggatgagacaggcccctggacagggccttgaatggatgggaggcatcatccccatcttcggccctgctaagcacgcccagaaattccagggcagagtgaccatcaccgccgacaagtctacctccaccgtgtacatggaactgtccagcctgagatccgaggacaccgccgtgtactactgtgctagactcgtgggcgctaccggatggttcgatccttggggacagggcacactggtcaccgtgtcctctgcttctaccaagggacccagcgtgttccctctggctcctagctctaagtccacctccggtggaacagctgctctgggctgtctggtcaaggactacttccctgagcctgtgaccgtgtcttggaactctggcgctctgacatccggcgtgcacacctttccagctgtgctgcaatcctccggcctgtactctctgtcctccgtcgtgaccgtgccttctagctctctgggcacccagacctacatctgcaatgtgaaccacaagccttccaacaccaaggtggacaagaaggtggaacccaagtcctgcgacaagacccacacctgtcctccatgtcctgctccagaagctgcaggcggcccttccgtgtttctgttccctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcacgaggacccagaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaactccacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggcactgcctgccggcatcgaaaagaccatctccaaggctaagggccagcctcgggaaccccaggtttacacattgcctccatctcgggacgagctgaccaagaaccaggtgtccctgtcttgtgccgtgaagggcttctacccctccgatatcgctgtggaatgggagtccaatggccagccagagaacaactacaagacaacccctcctgtgctggactccgacggctcattcttcctggtgtccaagctgacagtggacaagtccagatggcagcagggcaacgtgttctcctgctccgtgatgcacgaggccctgcacaatcactacacacagaagtctctgtctctgtcccctggcaag 449 AA PAT source 1..449 mol_type protein note tA3-20_HC_hole organism synthetic construct QVQLVQSGAEVKKPGSSVKVSCKASGGTFNSYAISWMRQAPGQGLEWMGGIIPIFGPAKHAQKFQGRVTITADKSTSTVYMELSSLRSEDTAVYYCARLVGATGWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 1347 DNA PAT source 1..1347 mol_type other DNA note 2A4_HC_control organism synthetic construct gaggttcaacttgttgaaagtggcggaagattagtgcagcccaaaggctccctcaaactgtcttgtgctgcaagtggctttacgtttaacacctatgccatgtattggatccggcaggcaccaggtaaagggttagaatgggtggcacgaatccgcagtaagtcaaataactacgccatctactacgccgacagcgttaaagataggttcaccatcttccgcgacgacagccagagcatgctgtatctccagatgaacaacctgaagacggaggataccgctatgtactactgcgtcaggccctactcagacagtttcgcctattggggccagggtactcttgtaactgtctccgctgctagcaccaagggacccagcgtgttccctctggctcctagctctaagtccacctctggcggaacagctgctctgggctgtctggtcaaggactacttccctgagcctgtgaccgtgtcctggaactctggcgctctgacatctggcgtgcacacattccctgctgtgctgcagtcctccggcctgtactctctgtcctctgtcgtgaccgtgccttccagctctctgggaacccagacctacatctgcaatgtgaaccacaagccttccaacaccaaggtggacaagaaggtggaacccaagtcctgcgacaagacccacacctgtcctccatgtcctgctccagaactgctcggcggaccttccgtgttcctgtttcctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcacgaggacccagaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaactccacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgctcctatcgaaaagaccatctccaaggccaagggccagcctagggaaccccaggtttacaccttgcctccatctcgggacgagctgaccaagaaccaggtgtccctgacctgtctcgtgaagggcttctacccttccgatatcgccgtggaatgggagtctaacggccagccagagaacaactacaagacaacccctcctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggataagtcccggtggcagcagggcaacgtgttctcttgctctgtgatgcacgaggccctgcacaaccactacacacagaagtctctgtctctgagccccggcaag 449 AA PAT source 1..449 mol_type protein note 2A4_HC_control organism synthetic construct EVQLVESGGRLVQPKGSLKLSCAASGFTFNTYAMYWIRQAPGKGLEWVARIRSKSNNYAIYYADSVKDRFTIFRDDSQSMLYLQMNNLKTEDTAMYYCVRPYSDSFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 657 DNA PAT source 1..657 mol_type other DNA note 2A4_LC_control organism synthetic construct gacgttgttatgacacaaactccactctctttaccagtctctctaggggatcaggccagcattagctgccgatcttctcagagtctggtccattcaaccggaaatacctatctgcactggtacctccagaagcccggtcaatctccaaaactgctgatctacaaggtcagcaaccgcttcagcggcgtaccagatagattttccggctccggcagcggcacatacttcacactcaaaattagcagggtcgaggcagaagatcttggtgtgtatttctgcagccagtccacccacgtccctttcacttttggaggtggaacgaagctcgagatcaagcgtacggtggccgctccttccgtgttcatcttcccaccttccgacgagcagctgaagtccggcacagcttctgtcgtgtgcctgctgaacaacttctaccctcgggaagccaaggtgcagtggaaggtggacaatgccctgcagtccggcaactcccaagagtctgtgaccgagcaggactccaaggacagcacctacagcctgtcctccacactgaccctgtccaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccatcagggcctgtctagccctgtgaccaagtctttcaaccggggcgagtgc 219 AA PAT source 1..219 mol_type protein note 2A4_LC_control organism synthetic construct DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSTGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTYFTLKISRVEAEDLGVYFCSQSTHVPFTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1350 DNA PAT source 1..1350 mol_type other DNA note M6_HC_control organism synthetic construct caagtgaagctggaagagtctggccccgagctgaagaaacctggcgagacagtgaagatctcctgcaaggcctccggctacaccttcaccaactacggcatgaactgggtcaagcaggctcctggcaagggcctgaaatggatgggctggatcaacacctacaccggcgagcctacctacgccgacgatttcaagggcagattcgtgttctccctggaaacctccgcctccaccgcttacctgcagatcaacaacctgaagaacgaggacatggccacctacttttgcgcccggaagtccaccgtggtgtccagatacttcgatgtgtggggcgctggcaccaccgtgacagtgtcctctgctagcacaaagggcccctctgtgttccctctggctcctagctctaagtccacctctggcggaacagctgctctgggctgtctggtcaaggactacttccctgagcctgtgaccgtgtcttggaactctggcgctctgacatccggcgtgcacacatttccagctgtgctgcagtcctccggcctgtactctctgtcctctgtcgtgaccgtgccttccagctctctgggaacccagacctacatctgcaatgtgaaccacaagccttccaacaccaaggtggacaagaaggtggaacccaagtcctgcgacaagacccacacctgtcctccatgtcctgctccagaagctgctggcggaccttccgtgttcctgtttcctccaaagcctaaggacaccctgatgatctctcggacccctgaagtgacctgcgtggtggtggatgtgtctcacgaggacccagaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaactccacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgccggcatcgaaaagaccatctccaaggccaagggccagcctagggaaccccaggtttacaccttgccaccttctcgggacgagctgaccaagaaccaggtgtccctgacctgtctcgtgaagggcttctacccctccgatatcgccgtggaatgggagtctaatggccagcctgagaacaactacaagacaacccctcctgtgctggactccgacggctcattcttcctgtactccaagctgacagtggacaagtccagatggcagcagggcaacgtgttctcctgcagcgtgatgcacgaggccctgcacaatcactacacacagaagtctctgtctctgagccccggcaag 450 AA PAT source 1..450 mol_type protein note M6_HC_control organism synthetic construct QVKLEESGPELKKPGETVKISCKASGYTFTNYGMNWVKQAPGKGLKWMGWINTYTGEPTYADDFKGRFVFSLETSASTAYLQINNLKNEDMATYFCARKSTVVSRYFDVWGAGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 642 DNA PAT source 1..642 mol_type other DNA note M6_LC_control organism synthetic construct gacatcgtgctgacccagacacacaagttcatgtccacctccgtgggcgacagagtgtccatcacatgcaaggcctctcaggatgtgggcgacgctgtgacatggtgccagcagaaacctggccagcctcctaagctgctgatctactgggcctctaccagacataccggcgtgcccgatagattcaccggctctggctctggcaccgacttcaccctgaccatcaacaacgtgcagtccgaggacctggccgactacttctgccagcagtaccggtcttaccctctgacctttggagccggcaccaagctggaactgaagcgtacggtggccgctccttccgtgttcatcttcccaccttccgacgagcagctgaagtccggcacagcttctgtcgtgtgcctgctgaacaacttctaccctcgggaagccaaggtgcagtggaaggtggacaatgccctgcagtccggcaactcccaagagtctgtgaccgagcaggactccaaggacagcacctacagcctgtcctccacactgaccctgtccaaggccgactacgagaagcacaaggtgtacgcctgcgaagtgacccatcagggcctgtctagccctgtgaccaagtctttcaaccggggcgagtgc 214 AA PAT source 1..214 mol_type protein note M6_LC_control organism synthetic construct DIVLTQTHKFMSTSVGDRVSITCKASQDVGDAVTWCQQKPGQPPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTINNVQSEDLADYFCQQYRSYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 15 AA PAT source 1..15 mol_type protein note Hinge2 organism synthetic construct EPKSSDKTHTCPPCP