51139-032WO2 US 63/241,836 2021-09-08 Orchard Therapeutics (Europe) Limited COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 20 689 DNA PAT source 1..689 mol_type genomic DNA organism Homo sapiens ttcccatccacacatagagcttcagattctctttctttccccagagaccctcaaatatcctctcactcacagaatggtgtctctgcctgcctcgggttggccctgtgatttattttagttcttttcccttgttttttttttttcaaactctatacacttttgttttaaaaactgtggtttctcatgagccctattatctcattgatacctctcacctctgtggtgaggggaagaaatcatattttcagatgactcgtaaagggcaaagaaaaaaacccaaaatttcaaaatttccgtttaagtctcataatcaagaaaaggagaaacacagagagagagaaaaaaaaaactatgagaacccccccccaccccgtgattatcagcgcacacactcatcgaaaaaaatttggattattagaagagagaggtctgcggcttccacaccgtacagcgtggtttttcttctcggtataaaagcaaagttgtttttgatacgtgacagtttcccacaagccaggctgatccttttctgtcagtccacttcaccaaggtgagtgtccctgctctcccctaccagatgtgggccccattggaggagatggcagggaggtaggcacggcgggggggtcaggggccctctggtacagtgggatgtacccagctaccgtgattccagccaggtaaggtct 482 DNA PAT source 1..482 mol_type genomic DNA organism Homo sapiens gcttcagattctctttctttccccagagaccctcaaatatcctctcactcacagaatggtgtctctgcctgcctcgggttggccctgtgatttattttagttcttttcccttgttttttttttttcaaactctatacacttttgttttaaaaactgtggtttctcatgagccctattatctcattgatacctctcacctctgtggtgaggggaagaaatcatattttcagatgactcgtaaagggcaaagaaaaaaacccaaaatttcaaaatttccgtttaagtctcataatcaagaaaaggagaaacacagagagagagaaaaaaaaaactatgagaacccccccccaccccgtgattatcagcgcacacactcatcgaaaaaaatttggattattagaagagagaggtctgcggcttccacaccgtacagcgtggtttttcttctcggtataaaagcaaagttgtttttgatacgtgac 420 DNA PAT source 1..420 mol_type genomic DNA organism Homo sapiens gcttcagatcccttcttctgttcaacccagcgatcctccaacgtctcacaaacacaatgctgtctctacctgcctcgggatgcctttgtgatttgacttattttccctcagttttttttttctgactctacacacttttgtttaagaaattgtggtttctcatgagccctgttatctcattgataccttttacctctgtggtgaggggaagaaatcatattttcagatgacttgtaaagggcaaagaaaaaacccaaaatttcaaaatttccgtttaagtctcataagaaaagaataaacaaagtaagagagcaaagaaaaaaaaactacaagaaccccccccccaccctgcaattatcagcacacacactcatcaaaaaaaaattggattattagaagagcgaggtctgcggcttccac 424 DNA PAT source 1..424 mol_type genomic DNA organism Homo sapiens gcttcagattctctttctttccccagagaccctcaaatatcctctcactcacagaatggtgtctctgcctgcctcgggttggccctgtgatttattttagttcttttcccttgttttttttttttcaaactctatacacttttgttttaaaaactgtggtttctcatgagccctattatctcattgatacctctcacctctgtggtgaggggaagaaatcatattttcagatgactcgtaaagggcaaagaaaaaaacccaaaatttcaaaatttccgtttaagtctcataatcaagaaaaggagaaacacagagagagagaaaaaaaaaactatgagaacccccccccaccccgtgattatcagcgcacacactcatcgaaaaaaatttggattattagaagagagaggtctgcggcttccac 150 DNA PAT source 1..150 mol_type genomic DNA organism Homo sapiens tttaagtcttttgcacttgaaaatgagataactgttcaccccatgttggcttccagtctcctttatggcttcattttttccatttactgcagaggtcaaaagtgtgggtatgggagccagactgtctggaacaacctagcctcaactcaa 148 DNA PAT source 1..148 mol_type genomic DNA organism Homo sapiens aagtcctttcctacttgaaaatgagataaatgttcacctatgttggcttctagtctcttttatggcttcattttttccatttactatagaggttaagagtgtgggtactggagccagactgtctgggacaaacccagcgtcaccccaa 341 DNA PAT source 1..341 mol_type genomic DNA organism Homo sapiens tagattactcttttcttgtggggcttctgtgtatggttttgtgttttaagtcttttgcacttgaaaatgagataactgttcaccccatgttggcttccagtctcctttatggcttcattttttccatttactgcagaggtcaaaagtgtgggtatgggagccagactgtctggaacaacctagcctcaactcaagtcatctgtgtgaattttacccaggctcttaacctctctgtacctccatttcctcgtatgtactgtgatgattataacagtacctacctcagaggatctttctgaggattatttttattaatgatggtaggtgctcagcacaaggcc 343 DNA PAT source 1..343 mol_type genomic DNA organism Homo sapiens taggttagtctttttttctgtggcttctgtctctggttttgtgcttagaaagtcctttcctacttgaaaatgagataaatgttcacctatgttggcttctagtctcttttatggcttcattttttccatttactatagaggttaagagtgtgggtactggagccagactgtctgggacaaacccagcgtcaccccaagccctatgtgtgatttttagccaggcacttaacctctccatacctccatttcctcatatgtactgcaatggttataatagtaccttcctcaggagtctttgtttagattaaaatttttaaccacagtaaatacttagcacaaggcc 403 DNA PAT source 1..403 mol_type genomic DNA organism Homo sapiens cagatggacgtcacctaccacatccgctagcacccacatcaccctacctgggcctatccggctacaggatagactagccacttctcggaacgaaacctgtggggtagattatctgcccccttctcttcctccttgttgccgatgaagcccaatgcatccggccgccatgacgtcaatggcagaaaaatctggccaagttcaggttgtgacaacagggcccagatgtagaccccgataggaaaacatattctatgtcccagaaacaacctccatacagcttctaagaaacagtcaaacaggaacgccccaacagacagtgcaggaagctggctggccagcccagccctccaggtccctagtaccactagacagaccatatccaattcaggtcctctttctgaga 383 DNA PAT source 1..383 mol_type genomic DNA organism Homo sapiens cagatggacatcacctaccacatccaccagcacccatgtcaccccacctgggccaagcctgctgcaggacagggcagccagttctcggaacgaaacctgtggggtggggtatctgccctcttctcttcctccgtggtgtcgatgaagcccggcgcatccggccgccatgacgtcaatggcggaaaaatctgggcaagtcgggggctgtgacaacagggcccagatgcagaccccgatatgaaaacataatctgtgtcccagaaacatcccccattcagcttctgagaaacccagtcagaaagggacgtcccaacagacagtgcaggaagccggctgcccagcccggccctctaggtcctctacccccagacagatcatctcca 426 DNA PAT source 1..426 mol_type genomic DNA organism Homo sapiens tgggttttgcatggtagccagatggacgtcacctaccacatccgctagcacccacatcaccctacctgggcctatccggctacaggatagactagccacttctcggaacgaaacctgtggggtagattatctgcccccttctcttcctccttgttgccgatgaagcccaatgcatccggccgccatgacgtcaatggcagaaaaatctggccaagttcaggttgtgacaacagggcccagatgtagaccccgataggaaaacatattctatgtcccagaaacaacctccatacagcttctaagaaacagtcaaacaggaacgccccaacagacagtgcaggaagctggctggccagcccagccctccaggtccctagtaccactagacagaccatatccaattcaggtcctctttctgagaatgta 420 DNA PAT source 1..420 mol_type genomic DNA organism Homo sapiens gggcttgtcatagtggccagatggacatcacctaccacatccaccagcacccatgtcaccccacctgggccaagcctgctgcaggacagggcagccagttctcggaacgaaacctgtggggtggggtatctgccctcttctcttcctccgtggtgtcgatgaagcccggcgcatccggccgccatgacgtcaatggcggaaaaatctgggcaagtcgggggctgtgacaacagggcccagatgcagaccccgatatgaaaacataatctgtgtcccagaaacatcccccattcagcttctgagaaacccagtcagaaagggacgtcccaacagacagtgcaggaagccggctgcccagcccggccctctaggtcctctacccccagacagatcatctccatgtccctgtctgagaatgta 207 DNA PAT source 1..207 mol_type genomic DNA organism Homo sapiens cccggggcccagaatggggtaagcagggtggggtacttgggcctataggtgtcgacctttactgtggcatgtggcgggggggggggggggggctggggcacaggaagtggtttatgggtcccaggcaagtctgacttatgcagatattgcagggccaagaaaatccccactctccaggcttcagagattcaaggctttccccacccc 201 DNA PAT source 1..201 mol_type genomic DNA organism Homo sapiens ccctgggcccaggatggggcaggcagggtggggtacctggacctacaggtgccgacctttactgtggcactgggcgggaggggggctggctggggcacaggaagtggtttctgggtcccaggcaagtctgtgacttatgcagatgttgcagggccaagaaaatccccacctgccaggcctcagagattggaggctctcccc 234 DNA PAT source 1..234 mol_type genomic DNA organism Homo sapiens gtgaggcccggggcccagaatggggtaagcagggtggggtacttgggcctataggtgtcgacctttactgtggcatgtggcgggggggggggggggggctggggcacaggaagtggtttatgggtcccaggcaagtctgacttatgcagatattgcagggccaagaaaatccccactctccaggcttcagagattcaaggctttccccacccctcccaatcctcatcccgatag 220 DNA PAT source 1..220 mol_type genomic DNA organism Homo sapiens gtgaggccctgggcccaggatggggcaggcagggtggggtacctggacctacaggtgccgacctttactgtggcactgggcgggaggggggctggctggggcacaggaagtggtttctgggtcccaggcaagtctgtgacttatgcagatgttgcagggccaagaaaatccccacctgccaggcctcagagattggaggctctccccgacctcccaatcc 447 DNA PAT source 1..447 mol_type genomic DNA organism Homo sapiens tcccctgaggtccaccaccatttccccagagggctggatcacggggggtagctattcttcaacagcacttcaaatcagcagcagcacacaggccttaaaacaataataagttgaaatgtatttgctaggaaagtcaccgacctacaaagaaaaccttatcgctgatctagcagcgcacaccagcctcccctttgcaagagctgagatcaaaagataaagaagctatcaaaaagccatctgcccacttaaaataacatctcaagtcacgttgggaaccacaaacatggggccagctaccaaaacaattgtctaaatgaactacttcaatttctccttaaaaccacccatgtattttaaaagaaaaacaccctctccacccaccttggcacggcaaggttttgatttgtctgttcccttcctttcacattcttgaaaatgaccaaactt 444 DNA PAT source 1..444 mol_type genomic DNA organism Homo sapiens agtttggtcattttaaagagtgtgaaaggcagagaacagagaaatcaaaaccttgcagggccaaggtgggtggagagggtgtttttcttttaacatacatgggcggttttaaggagaaattgaagcagcctgttcagacaattgttttggtatctggccccaggtctgtggttcctaacatgacttgtgatattattttaagtgggcagatggctttttgatagcttctttatctttcgatctcagctcttgcaaaggggaggttggtgctcattgcaagatcagcgataagggtttctttgtaggtcggtggctttcttggtgagtacatttcaacatattattgttttagaacctgtgtgctgccagtgacttgcagcactgttgaagactagccaccctttgtgacctagccctcttgggaaatggcggaggatctcaggg 601 DNA PAT source 1..601 mol_type genomic DNA organism Homo sapiens cagtgggcctgtggccaacgattctgaagccctctacagcaggcctcccacagataagaaaagggatcccctgaggtccaccaccatttccccagagggctggatcacggggggtagctattcttcaacagcacttcaaatcagcagcagcacacaggccttaaaacaataataagttgaaatgtatttgctaggaaagtcaccgacctacaaagaaaaccttatcgctgatctagcagcgcacaccagcctcccctttgcaagagctgagatcaaaagataaagaagctatcaaaaagccatctgcccacttaaaataacatctcaagtcacgttgggaaccacaaacatggggccagctaccaaaacaattgtctaaatgaactacttcaatttctccttaaaaccacccatgtattttaaaagaaaaacaccctctccacccaccttggcacggcaaggttttgatttgtctgttcccttcctttcacattcttgaaaatgaccaaacttcagtactcaactgtcttatcttccagaaagggctcccacaactgccgatggaataagaagtgattgaaatgcaggcgattctgggggc 531 DNA PAT source 1..531 mol_type genomic DNA organism Homo sapiens cggctgtcatgggaaccctgtctgtaagatgcgacagtttgggtaaaggagtttggtcattttaaagagtgtgaaaggcagagaacagagaaatcaaaaccttgcagggccaaggtgggtggagagggtgtttttcttttaacatacatgggcggttttaaggagaaattgaagcagcctgttcagacaattgttttggtatctggccccaggtctgtggttcctaacatgacttgtgatattattttaagtgggcagatggctttttgatagcttctttatctttcgatctcagctcttgcaaaggggaggttggtgctcattgcaagatcagcgataagggtttctttgtaggtcggtggctttcttggtgagtacatttcaacatattattgttttagaacctgtgtgctgccagtgacttgcagcactgttgaagactagccaccctttgtgacctagccctcttgggaaatggcggaggatctcagggtatatcccttacctgtgggagccctatcagagggcttc