P2024-0333 CN 202110990796.X 2021-08-26 TIOC THERAPEUTICS, LTD. LI, Yi POLYPEPTIDE FUSION MOLECULE CLOSE TO NATURAL MOLECULE 38 200 AA PAT source 1..200 mol_type protein note Amino acid sequence of 1G4 TCR alpha chain with mutation organism synthetic construct AQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLITPWQREQTSGRLNASLDKSSGRSTLYIAASQPGDSATYLCAVRPLVDPTYIPTFGRGTSLIVHPYIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDT 600 DNA PAT source 1..600 mol_type other DNA note Nucleic acid sequence of 1G4 TCR alpha chain with mutation organism synthetic construct gcccaagaagttacccaaatcccggcagccctgagtgtcccggaaggtgaaaatctggtcctgaattgctcgtttaccgatagcgccatttacaacctgcagtggtttcgtcaagatccgggcaaaggtctgaccagcctgctgctgatcacgccgtggcagcgtgaacaaaccagcggccgcctgaatgcctctctggataaaagctctggtcgcagcaccctgtatattgcagcatcacagccgggtgactcggctacgtacctgtgtgcggtgcgtccgctggttgatccgacctatatcccgacgtttggccgcggtaccagtctgattgttcatccgtatatccagaacccggatccggcggtctaccaactgcgtgatagtaaaagttccgacaaatccgtgtgcctgtttaccgatttcgactcacagacgaatgtttcacaatcgaaagattcggacgtctatattaccgataaatgtgtgctggacatgcgcagcatggatttcaaaagcaactctgcagtcgcttggagtaataaatccgactttgcgtgcgccaacgcattcaacaattctattatcccggaagatacg 241 AA PAT source 1..241 mol_type protein note Amino acid sequence of 1G4 TCR beta chain with mutation organism synthetic construct GVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 723 DNA PAT source 1..723 mol_type other DNA note Nucleic acid sequence of 1G4 TCR beta chain with mutation organism synthetic construct ggtgttacccagacgccgaaattccaagtcctgaaaaccggccagtcgatgacgctgcagtgtgcacaagatatgaatcatgaatatatgagctggtaccgccaagacccgggtatgggcctgcgtctgattcactatagcgtggccatccagaccacggatcaaggtgaagttccgaacggctacaatgtctcccgctcaaccacggaagactttccgctgcgtctgctgagcgcagcaccgtcgcagaccagcgtgtatttctgcgcaagctcttacgttggtaacaccggcgaactgtttttcggtgaaggcagccgcctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcggtgttcgaaccgtccgaagccgaaatttcacatacccagaaagcaacgctggtgtgcctggctaccggtttttatccggatcatgtggaactgtcttggtgggttaacggtaaagaagtgcacagtggcgtttgtacggatccgcagccgctgaaagaacaaccggcactgaatgactcccgttatgctctgagttcccgtctgcgcgtttcagccaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggtctgtctgaaaatgatgaatggacccaggaccgtgcaaaaccggtcacgcaaatcgtgagtgcagaagcttggggccgtgcagat 122 AA PAT source 1..122 mol_type protein organism Homo sapiens EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 366 DNA PAT source 1..366 mol_type other DNA organism Homo sapiens gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaaggcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggtcagggcaccctggtgaccgttagttcc 370 AA PAT source 1..370 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSSGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1110 DNA PAT source 1..1110 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaaggcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggtcagggcaccctggtgaccgttagttccggcggtggcggtagcaacgcaggtgttacccagacgccgaaattccaagtcctgaaaaccggccagtctatgacgctgcagtgtgcgcaagatatgaaccatgaatacatgagttggtaccgtcaggacccgggtatgggtctgcgtctgattcactattctgtggcgatccagaccacggatcaaggtgaagttccgaacggctacaatgtctcgcgtagcaccacggaagactttccgctgcgtctgctgtccgcagctccgtcccagacctcagtgtatttctgcgcctcatcgtacgttggtaacaccggcgaactgtttttcggtgaaggcagccgtctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcagtgttcgaaccgtcggaagctgaaattagccatacccagaaagcgacgctggtttgcctggccaccggtttttatccggatcatgtggaactgtcctggtgggttaacggtaaagaagtgcactcaggcgtttgtacggatccgcagccgctgaaagaacaaccggcgctgaatgactcgcgctatgccctgagctctcgtctgcgcgttagcgcgaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggtctgtccgaaaatgatgaatggacccaggaccgtgcgaaaccggtcacgcaaatcgtgtcagcggaagcctggggccgcgcagat 5 AA PAT source 1..5 mol_type protein organism Homo sapiens GGGGS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIK 321 DNA PAT source 1..321 mol_type other DNA organism Homo sapiens gatattcagatgacgcaatccccgagttccctgtcagcttcggttggtgatcgtgtcaccattacgtgtcgcgcgagccaggacatccgtaactatctgaattggtaccagcaaaaaccgggtaaagctccgaaactgctgatttattacacctcccgtctggaatcaggtgtgccgtcgcgttttagcggctctggtagtggcaccgattataccctgacgatctcatcgctgcagccggaagactttgcgacgtattactgccagcaaggcaacaccctgccgtggacgttcggtcagggcaccaaagttgaaatcaaa 355 AA PAT source 1..355 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1065 DNA PAT source 1..1065 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gatattcagatgacgcaatccccgagttccctgtcagcttcggttggtgatcgtgtcaccattacgtgtcgcgcgagccaggacatccgtaactatctgaattggtaccagcaaaaaccgggtaaagctccgaaactgctgatttattacacctcccgtctggaatcaggtgtgccgtcgcgttttagcggctctggtagtggcaccgattataccctgacgatctcatcgctgcagccggaagactttgcgacgtattactgccagcaaggcaacaccctgccgtggacgttcggtcagggcaccaaagttgaaatcaaaggcggtggcggtagcaatgccggtgttacccagacgccgaaattccaagtcctgaaaaccggccagtcgatgacgctgcagtgtgcacaagatatgaatcatgaatatatgagctggtaccgccaagacccgggtatgggcctgcgtctgattcactatagcgtggccatccagaccacggatcaaggtgaagttccgaacggctacaatgtctcccgctcaaccacggaagactttccgctgcgtctgctgagcgcagcaccgtcgcagaccagcgtgtatttctgcgcaagctcttacgttggtaacaccggcgaactgtttttcggtgaaggcagccgcctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcggtgttcgaaccgtccgaagccgaaatttcacatacccagaaagcaacgctggtgtgcctggctaccggtttttatccggatcatgtggaactgtcttggtgggttaacggtaaagaagtgcacagtggcgtttgtacggatccgcagccgctgaaagaacaaccggcactgaatgactcccgttatgctctgagttcccgtctgcgcgtttcagccaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggtctgtctgaaaatgatgaatggacccaggaccgtgcaaaaccggtcacgcaaatcgtgagtgcagaagcctggggccgcgcagat 122 AA PAT source 1..122 mol_type protein note Amino acid sequence of heavy chain variable region with mutation organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 366 DNA PAT source 1..366 mol_type other DNA note Nucleic acid sequence of heavy chain variable region with mutation organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaatgcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggtcagggcaccctggtgaccgttagttcc 108 AA PAT source 1..108 mol_type protein note Amino acid sequence of light chain variable region with mutation organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGCGTKVEIKR 324 DNA PAT source 1..324 mol_type other DNA note Nucleic acid sequence of light chain variable region with mutation organism synthetic construct gatattcagatgacgcagtctccgagcagcctgtccgcctccgtgggtgaccgtgttaccattacctgtcgtgccagccaagatattcgtaactatctgaattggtaccagcaaaaaccgggtaaagccccgaaactgctgatttattacacctcgcgtctggaaagcggcgtgccgtctcgctttagtggctccggttcaggcaccgattataccctgacgatcagctctctgcagccggaagactttgcaacgtattactgccagcagggtaacaccctgccgtggacgttcggttgcggcaccaaagttgaaattaaacgt 370 AA PAT source 1..370 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKCLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSSGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1110 DNA PAT source 1..1110 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaatgcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggtcagggcaccctggtgaccgttagttccggcggtggcggtagcaacgcaggtgttacccagacgccgaaattccaagtcctgaaaaccggccagtctatgacgctgcagtgtgcgcaagatatgaaccatgaatacatgagttggtaccgtcaggacccgggtatgggtctgcgtctgattcactattctgtggcgatccagaccacggatcaaggtgaagttccgaacggctacaatgtctcgcgtagcaccacggaagactttccgctgcgtctgctgtccgcagctccgtcccagacctcagtgtatttctgcgcctcatcgtacgttggtaacaccggcgaactgtttttcggtgaaggcagccgtctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcagtgttcgaaccgtcggaagctgaaattagccatacccagaaagcgacgctggtttgcctggccaccggtttttatccggatcatgtggaactgtcctggtgggttaacggtaaagaagtgcactcaggcgtttgtacggatccgcagccgctgaaagaacaaccggcgctgaatgactcgcgctatgccctgagctctcgtctgcgcgttagcgcgaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggtctgtccgaaaatgatgaatggacccaggaccgtgcgaaaccggtcacgcaaatcgtgtcagcggaagcctggggccgcgcagat 122 AA PAT source 1..122 mol_type protein note Amino acid sequence of heavy chain variable region with mutation organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGCGTLVTVSS 366 DNA PAT source 1..366 mol_type other DNA note Nucleic acid sequence of heavy chain variable region with mutation organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaaggcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggttgcggcaccctggtgaccgttagttcc 108 AA PAT source 1..108 mol_type protein note Amino acid sequence of light chain variable region with mutation organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKCPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKR 324 DNA PAT source 1..324 mol_type other DNA note Nucleic acid sequence of light chain variable region with mutation organism synthetic construct gatattcagatgacgcagtctccgagcagcctgtccgcctccgtgggtgaccgtgttaccattacctgtcgtgccagccaagatattcgtaactatctgaattggtaccagcaaaaaccgggtaaatgcccgaaactgctgatttattacacctcgcgtctggaaagcggcgtgccgtctcgctttagtggctccggttcaggcaccgattataccctgacgatcagctctctgcagccggaagactttgcaacgtattactgccagcagggtaacaccctgccgtggacgttcggtcagggcaccaaagttgaaattaaacgt 370 AA PAT source 1..370 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGCGTLVTVSSGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1110 DNA PAT source 1..1110 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaaggcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggttgcggcaccctggtgaccgttagttccggcggtggcggtagcaacgcaggtgttacccagacgccgaaattccaagtcctgaaaaccggccagtctatgacgctgcagtgtgcgcaagatatgaaccatgaatacatgagttggtaccgtcaggacccgggtatgggtctgcgtctgattcactattctgtggcgatccagaccacggatcaaggtgaagttccgaacggctacaatgtctcgcgtagcaccacggaagactttccgctgcgtctgctgtccgcagctccgtcccagacctcagtgtatttctgcgcctcatcgtacgttggtaacaccggcgaactgtttttcggtgaaggcagccgtctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcagtgttcgaaccgtcggaagctgaaattagccatacccagaaagcgacgctggtttgcctggccaccggtttttatccggatcatgtggaactgtcctggtgggttaacggtaaagaagtgcactcaggcgtttgtacggatccgcagccgctgaaagaacaaccggcgctgaatgactcgcgctatgccctgagctctcgtctgcgcgttagcgcgaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggtctgtccgaaaatgatgaatggacccaggaccgtgcgaaaccggtcacgcaaatcgtgtcagcggaagcctggggccgcgcagat 355 AA PAT source 1..355 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKCPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1065 DNA PAT source 1..1065 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gatattcagatgacgcagtctccgagcagcctgtccgcctccgtgggtgaccgtgttaccattacctgtcgtgccagccaagatattcgtaactatctgaattggtaccagcaaaaaccgggtaaatgcccgaaactgctgatttattacacctcgcgcctggaaagcggtgtgccgtctcgttttagcggttctggcagtggtaccgattataccctgacgatctcatcgctgcagccggaagactttgcgacgtattactgccagcagggtaacaccctgccgtggacgttcggccagggtaccaaagttgaaatcaaaggtggcggtggcagcaatgccggcgttacccagacgccgaaattccaagtcctgaaaaccggccagtctatgacgctgcagtgtgcacaagatatgaaccatgaatacatgagttggtaccgccaagacccgggcatgggtctgcgtctgattcactatagcgtggccatccagaccacggatcaaggcgaagttccgaacggttacaatgtctcccgctcaaccacggaagactttccgctgcgtctgctgagcgcagcaccgtcgcagaccagcgtgtatttctgcgcaagctcttacgttggcaacaccggtgaactgtttttcggcgaaggttctcgcctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcggtgttcgaaccgtcggaagccgaaattagccatacccagaaagcaacgctggtgtgcctggctaccggcttttatccggatcatgtggaactgtcctggtgggttaacggcaaagaagtgcactcaggtgtttgtacggatccgcagccgctgaaagaacaaccggcactgaatgactcgcgttatgctctgagttcccgtctgcgcgttagcgccaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggcctgtccgaaaatgatgaatggacccaggaccgtgcaaaaccggtcacgcaaatcgtgtcagcagaagcctggggccgcgcagat 355 AA PAT source 1..355 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct SITE 240 note Xaa can be any naturally occurring amino acid DIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGCGTKVEIKGGGGSNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVAIQTTDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVAVFXPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1065 DNA PAT source 1..1065 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gatattcagatgacgcagtctccgagcagcctgtccgcctccgtgggtgaccgtgttaccattacctgtcgtgccagccaagatattcgtaactatctgaattggtaccagcaaaaaccgggtaaagccccgaaactgctgatttattacacctcgcgtctggaaagcggcgtgccgtctcgctttagtggctccggttcaggcaccgattataccctgacgatcagctctctgcagccggaagactttgcaacgtattactgccagcagggtaacaccctgccgtggacgttcggttgcggcaccaaagttgaaatcaaaggtggcggtggcagcaatgccggcgttacccagacgccgaaattccaagtcctgaaaaccggccagtctatgacgctgcagtgtgcacaagatatgaaccatgaatacatgagttggtaccgccaagacccgggcatgggtctgcgtctgattcactatagcgtggccatccagaccacggatcaaggcgaagttccgaacggttacaatgtctcccgctcaaccacggaagactttccgctgcgtctgctgagcgcagcaccgtcgcagaccagcgtgtatttctgcgcaagctcttacgttggcaacaccggtgaactgtttttcggcgaaggttctcgcctgacggtcctggaagatctgaaaaatgtgtttccgccggaagtcgcggtgttcraaccgtcggaagccgaaattagccatacccagaaagcaacgctggtgtgcctggctaccggcttttatccggatcatgtggaactgtcctggtgggttaacggcaaagaagtgcactcaggtgtttgtacggatccgcagccgctgaaagaacaaccggcactgaatgactcgcgttatgctctgagttcccgtctgcgcgttagcgccaccttctggcaggatccgcgtaaccactttcgctgtcaggtccaattctacggcctgtccgaaaatgatgaatggacccaggaccgtgcaaaaccggtcacgcaaatcgtgtcagcagaagcctggggccgcgcagat 205 AA PAT source 1..205 mol_type protein note Amino acid sequence of AFP TCR alpha chain with mutation organism synthetic construct SQQGEEDPQALSIQEGENATMNCSYKDRITNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATDLEAEYKYIFGTGTRLKVLANIQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFCSPESS 618 DNA PAT source 1..618 mol_type other DNA note Nucleic acid sequence of AFP TCR alpha chain with mutation organism synthetic construct agtcaacagggagaagaggatcctcaggccttgagcatccaggagggtgaaaatgccaccatgaactgcagttacaaagatcgtataaccaatttacagtggtatagacaaaattcaggtagaggccttgtccacctaattttaatacgttcaaatgaaagagagaaacacagtggaagattaagagtcacgcttgacacttccaagaaaagcagttccttgttgatcacggcttcccgggcagcagacactgcttcttacttctgtgctacggacctggaagcagaatacaaatacatctttggaacaggcaccaggctgaaggttttagcaaatatccagaacccagaccccgccgtgtatcagctgagggactccaagagctccgataagagcgtgtgcctgttcaccgactttgattctcagacaaacgtgagccagtctaaggacagcgacgtgtacatcaccgacaagacagtgctggatatgcgctccatggacttcaagagcaactccgccgtggcctggtctaataagagcgatttcgcctgcgccaacgcctttaacaattccatcatccctgaggataccttcttttgttctccagaaagttcctaa 368 AA PAT source 1..368 mol_type protein note Amino acid sequence of fusion protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGCGTLVTVSSGGGGSETGVTQSPTHLIKTRGQQVTLRCSSQSGHNTVSWYQQALGQGPQFIFQYYRQVANGRGNFPPRFSGLQFPNYSSELNVNALELDDSALYLCASSKDAGPVFFGQGTRLTVVEDLKNVFPPEVAVFEPSECEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYALSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD 1107 DNA PAT source 1..1107 mol_type other DNA note Nucleic acid sequence of fusion protein organism synthetic construct gaagttcagctggtcgaaagcggtggcggtctggtccaaccgggcggttcactgcgtctgtcgtgtgcggcctctggttatagttttaccggctacacgatgaattgggttcgccaggcaccgggtaaaggcctggaatgggtcgctctgattaacccgtataaaggcgtgtctacctacaatcagaaatttaaagatcgcttcaccatcagcgtggacaaatctaaaaacacggcatatctgcaaatgaatagtctgcgtgcagaagataccgctgtgtattactgcgctcgctctggttattacggcgatagtgactggtattttgacgtttggggttgcggcaccctggtgaccgttagttccggcggtggcggtagcgaaactggagtaacccaaagtcccacacacctgatcaaaacgagaggacagcaagtgactctgagatgctcttctcagtctgggcacaacactgtgtcctggtaccaacaggccctgggtcaggggccccagtttatctttcagtattataggcaggtggcgaatggcagaggaaacttccctcctagattctcaggtctccagttccctaattatagctctgagctgaatgtgaacgccttggagctggacgactcggccctgtatctctgtgccagcagcaaggacgcgggtccggttttctttggacaaggcaccagactcacagttgtagaggacctgaagaacgtgttcccccctgaggtggccgtgtttgagccaagcgagtgcgagatctcccacacccagaaggccaccctggtgtgcctggccacaggcttctaccccgatcacgtggagctgagctggtgggtgaacggcaaggaggtgcacagcggcgtgtccaccgacccacagcccctgaaggagcagcctgccctgaatgattctagatacgccctgtctagccggctgagagtgagcgccaccttttggcagaacccacggaatcacttcagatgtcaggtgcagttttatggcctgagcgagaacgatgagtggacccaggacagggcaaagccagtgacacagatcgtgtccgccgaggcttggggtcgtgcagattaa 90 AA PAT source 1..90 mol_type protein note Amino acid sequence of TRAC*01 with mutation organism synthetic construct IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSP 128 AA PAT source 1..128 mol_type protein note Amino acid sequence of TRBC*01 with mutation organism synthetic construct DLNKVFPPEVAVFEPSEAEISHTQKATLVCLATGFFPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA 128 AA PAT source 1..128 mol_type protein note Amino acid sequence of TRBC*02 with mutation organism synthetic construct DLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRA 9 AA PAT source 1..9 mol_type protein organism Homo sapiens SLLMWITQC 9 AA PAT source 1..9 mol_type protein organism Homo sapiens FMNKFIYEI