WO 75FS-335587-WO2 WO PCT/CN2021/123368 2021-10-12 Concept to Medicine Biotech Co., Ltd. SINGLE-DOMAIN 4-1BB ANTIBODIES 44 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQAGGSLRLSCAASGDIFSIMFWYRQPQGKQREYVAHITSNGRTNYADSVTGRFTISRGNNDNTMYLQMDNLKPQDTAVYYCAADDATNTRTYWGQGTQVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGFTLDYYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTQVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTQVTVSS 116 AA PAT source 1..116 mol_type protein organism synthetic construct EVQLVESGGGLVQAGGSLRLSCAASGSIFSYMFWYRQPQGKQREYVAHITSGGRTNYADSVTGRFTISRGNNDNTMYLQMNNLKPEDTAVYYCAADDAVYTDRTYWGQGTQVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLSLDYYAIGWFRQAPGKEREGVSCISSSGRSTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYCATDTTTRCPIWSNYVESDYWGQGTQVTVSS 4 AA PAT source 1..4 mol_type protein organism synthetic construct SIMF 16 AA PAT source 1..16 mol_type protein organism synthetic construct HITSNGRTNYADSVTG 9 AA PAT source 1..9 mol_type protein organism synthetic construct DDATNTRTY 5 AA PAT source 1..5 mol_type protein organism synthetic construct YYAIG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSDGSTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct DTTTRCPIWSYYVESDY 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYAIG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSDGSTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct DTTTRCPIWSYYVESDY 4 AA PAT source 1..4 mol_type protein organism synthetic construct SYMF 16 AA PAT source 1..16 mol_type protein organism synthetic construct HITSGGRTNYADSVTG 10 AA PAT source 1..10 mol_type protein organism synthetic construct DDAVYTDRTY 5 AA PAT source 1..5 mol_type protein organism synthetic construct YYAIG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSGRSTNYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct DTTTRCPIWSNYVESDY 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCSASGDIFSIMFWYRQAPGKQREYVSHITSNGRTNYADSVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAADDATNTRTYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGDIFSIMFWYRQAPGKQREYVAHITSNGRTNYADSVTGRFTISRDNNKNTLYLQMNSLRAEDTAVYYCAADDATNTRTYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGDIFSIMFWYRQAPGKQREYVAHITSNGRTNYADSVTGRFTISRDNSKNTMYLQMDSLRAEDTAVYYCAADDATNTRTYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGDIFSIMFWYRQPQGKQREYVAHITSNGRTNYADSVTGRFTISRDNNKNTLYLQMDSLRAEDTAVYYCAADDATNTRTYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCSASGDIFSIMFWYRQAPGKQREYVAHITSNGRTNYADSVTGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDDATNTRTYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWVRQAPGKGLEWVSCISSSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCAKDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFAFSDYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSYYAIGWVRQAPGKGLEWVSCISSSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSYYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTLDYYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTLDYYAIGWFRQAPGKEREGVSCISSSDGSTYYADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYYCATDTTTRCPIWSYYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSYYAIGWVRQAPGKGLEWVSCISSSGRSTNYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDTTTRCPIWSNYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFSYYAIGWFRQAPGKEREGVSCISSSGRSTNYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSNYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTFSYYAIGWFRQAPGKEREGVSCISSSGRSTNYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDTTTRCPIWSNYVESDYWGQGTLVTVSS 126 AA PAT source 1..126 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGLTLSYYAIGWFRQAPGKEREGVSCISSSGRSTNYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTADYYCATDTTTRCPIWSNYVESDYWGQGTLVTVSS 16 AA PAT source 1..16 mol_type protein organism synthetic construct HITSNARTNYADSVTG 16 AA PAT source 1..16 mol_type protein organism synthetic construct HITSQGRTNYADSVTG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSDASTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSEGSTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSDASTYYADSVKG 17 AA PAT source 1..17 mol_type protein organism synthetic construct CISSSEGSTYYADSVKG