P22-173WO JP 2021-135138 2021-08-20 大塚製薬株式会社 OTSUKA PHARMACEUTICAL CO., LTD. 組み合わせ医薬 Combined drug 21 8 AA PAT source 1..8 mol_type protein note CDR1 of VH organism synthetic construct GVSLPDYG 7 AA PAT source 1..7 mol_type protein note CDR2 of VH organism synthetic construct IWGSETT 14 AA PAT source 1..14 mol_type protein note CDR3 of VH organism synthetic construct AKHYYYGGSYAMDY 6 AA PAT source 1..6 mol_type protein note CDR1 of VL organism synthetic construct QDISKY 000 9 AA PAT source 1..9 mol_type protein note CDR3 of VL organism synthetic construct QQGNTLPYT 8 AA PAT source 1..8 mol_type protein note CDR1 of VH organism synthetic construct GYTFSSYW 8 AA PAT source 1..8 mol_type protein note CDR2 of VH organism synthetic construct MLPGSGSS 12 AA PAT source 1..12 mol_type protein note CDR3 of VH organism synthetic construct ARGDGNYWYFDV 5 AA PAT source 1..5 mol_type protein note CDR1 of VL organism synthetic construct SSVGY 000 9 AA PAT source 1..9 mol_type protein note CDR3 of VL organism synthetic construct QQWSSDPPT 39 AA PAT source 1..39 mol_type protein note extracellular domain organism synthetic construct IEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKP 112 AA PAT source 1..112 mol_type protein note intracellular signaling domain organism synthetic construct RVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 41 AA PAT source 1..41 mol_type protein note intracellular signaling domain organism synthetic construct RSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 27 AA PAT source 1..27 mol_type protein note transmembrane domain organism synthetic construct FWVLVVVGGVLACYSLLVTVAFIIFWV 18 AA PAT source 1..18 mol_type protein note linker organism synthetic construct GSTSGSGKPGSGEGSTKG 18 AA PAT source 1..18 mol_type protein note linker organism synthetic construct GSTSGGGSGGGSGGGGSS 22 AA PAT source 1..22 mol_type protein note signal peptide organism synthetic construct MLLLVTSLLLCELPHPAFLLIP 489 AA PAT source 1..489 mol_type protein note CAR organism synthetic construct MLLLVTSLLLCELPHPAFLLIPDIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGSTSGSGKPGSGEGSTKGEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSETTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGTSVTVSSAAAIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 485 AA PAT source 1..485 mol_type protein note CAR organism synthetic construct MDFQVQIFSFLLISASVIMSRGQIVLSQSPAILSASPGEKVTMTCRASSSVGYMHWFQQKPGSSPKPWIYATSNLASGVPARFSGSESGTSYSLTISRVEAEDAATYYCQQWSSDPPTFGGGTKLEIKRGSTSGSGKPGSGEGSQVQLQQSGAELMKPGASVKISCKASGYTFSSYWIEWVKQRPGHGLEWIGEMLPGSGSSNYNEKFKGKATFTADTSSNTAYMQLSSLTSEDSAVYYCARGDGNYWYFDVWGAGTTVTVSSAAAIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR