PF 241057PCT CN 202311629115.2 2023-11-30 JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. COMPOSITION CONTAINING PD-L1 BINDING MOLECULE AND BISPECIFIC ANTIBODY-DRUG CONJUGATE AND USE THEREOF 61 128 AA PAT source 1..128 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGKMSSRRCMAWFRQAPGKERERVAKLLTTSGSTYLADSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAADSFEDPTCTLVTSSGAFQYWGQGTLVTVSS 232 AA PAT source 1..232 mol_type protein organism synthetic construct EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 232 AA PAT source 1..232 mol_type protein organism synthetic construct EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 360 AA PAT source 1..360 mol_type protein organism synthetic construct QVQLVESGGGLVQPGGSLRLSCAASGKMSSRRCMAWFRQAPGKERERVAKLLTTSGSTYLADSVKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCAADSFEDPTCTLVTSSGAFQYWGQGTLVTVSSEPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVAVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAGIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 5 AA PAT source 1..5 mol_type protein organism synthetic construct RRCMA 17 AA PAT source 1..17 mol_type protein organism synthetic construct KLLTTSGSTYLADSVKG 19 AA PAT source 1..19 mol_type protein organism synthetic construct DSFEDPTCTLVTSSGAFQY 10 AA PAT source 1..10 mol_type protein organism synthetic construct GKMSSRRCMA 10 AA PAT source 1..10 mol_type protein organism synthetic construct KLLTTSGSTY 19 AA PAT source 1..19 mol_type protein organism synthetic construct DSFEDPTCTLVTSSGAFQY 7 AA PAT source 1..7 mol_type protein organism synthetic construct GKMSSRR 6 AA PAT source 1..6 mol_type protein organism synthetic construct LTTSGS 19 AA PAT source 1..19 mol_type protein organism synthetic construct DSFEDPTCTLVTSSGAFQY 8 AA PAT source 1..8 mol_type protein organism synthetic construct GKMSSRRC 8 AA PAT source 1..8 mol_type protein organism synthetic construct LLTTSGST 21 AA PAT source 1..21 mol_type protein organism synthetic construct AADSFEDPTCTLVTSSGAFQY 119 AA PAT source 1..119 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSS 120 AA PAT source 1..120 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK 449 AA PAT source 1..449 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSALTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 450 AA PAT source 1..450 mol_type protein organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFKLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT source 1..5 mol_type protein organism synthetic construct DYTMD 17 AA PAT source 1..17 mol_type protein organism synthetic construct DVNPNSGGSIYNQRFKG 10 AA PAT source 1..10 mol_type protein organism synthetic construct NLGPSFYFDY 10 AA PAT source 1..10 mol_type protein organism synthetic construct GFTFTDYTMD 10 AA PAT source 1..10 mol_type protein organism synthetic construct DVNPNSGGSI 10 AA PAT source 1..10 mol_type protein organism synthetic construct NLGPSFYFDY 7 AA PAT source 1..7 mol_type protein organism synthetic construct GFTFTDY 6 AA PAT source 1..6 mol_type protein organism synthetic construct NPNSGG 10 AA PAT source 1..10 mol_type protein organism synthetic construct NLGPSFYFDY 8 AA PAT source 1..8 mol_type protein organism synthetic construct GFTFTDYT 8 AA PAT source 1..8 mol_type protein organism synthetic construct VNPNSGGS 12 AA PAT source 1..12 mol_type protein organism synthetic construct ARNLGPSFYFDY 5 AA PAT source 1..5 mol_type protein organism synthetic construct DTYIH 17 AA PAT source 1..17 mol_type protein organism synthetic construct RIYPTNGYTRYADSVKG 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGGDGFYAMDY 10 AA PAT source 1..10 mol_type protein organism synthetic construct GFNIKDTYIH 10 AA PAT source 1..10 mol_type protein organism synthetic construct RIYPTNGYTR 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGGDGFYAMDY 7 AA PAT source 1..7 mol_type protein organism synthetic construct GFNIKDT 6 AA PAT source 1..6 mol_type protein organism synthetic construct YPTNGY 11 AA PAT source 1..11 mol_type protein organism synthetic construct WGGDGFYAMDY 8 AA PAT source 1..8 mol_type protein organism synthetic construct GFNIKDTY 8 AA PAT source 1..8 mol_type protein organism synthetic construct IYPTNGYT 13 AA PAT source 1..13 mol_type protein organism synthetic construct SRWGGDGFYAMDY 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASFLYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYTTPPT 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASFLYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYTTPPT 11 AA PAT source 1..11 mol_type protein organism synthetic construct RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein organism synthetic construct SASFLYS 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYTTPPT 6 AA PAT source 1..6 mol_type protein organism synthetic construct QDVNTA 000 9 AA PAT source 1..9 mol_type protein organism synthetic construct QQHYTTPPT 336 AA PAT source 1..336 mol_type protein organism synthetic construct GSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS 398 AA PAT source 1..398 mol_type protein organism synthetic construct MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS 402 AA PAT source 1..402 mol_type protein organism synthetic construct MKFREPLLGGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLRRLPQLVGVHPPLQGSSHGAAAIGQPSGELRLRGVAPPPPLQNSSKPRSRAPSNLDAYSHPGPGPGPGSNLTSAPVPSTTTRSLTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQLFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS