WO PCT/US2023/014302 2023-03-01 2974-3 PCT US 63/315529 2022-02-28 CROSSLINK THERAPEUTICS INC. Rodolfo J. Chaparro ATP-DEPENDENT AGONISTS OF IMMUNE CELL FUNCTION AS ANTICANCER AGENTS 103 288 AA PAT REGION 1..288 note Description of sequence: Nucleotide binding domain of the ABCA1 gene product of UniProtKB - O95477 source 1..288 mol_type protein organism Homo sapiens RILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLA 257 AA PAT REGION 1..257 note Description of sequence: Nucleotide binding domain of ABCB1 gene product from UniProtKB - P08183 source 1..257 mol_type protein organism Homo sapiens EGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ 389 AA PAT REGION 1..389 note Description of sequence: Nucleotide binding domain of ABCC1 gene product from UniProtKB - P33527 source 1..389 mol_type protein organism Homo sapiens RRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG 280 AA PAT REGION 1..280 note Description of sequence: Nucleotide binding domain of he ABCD1 gene product from UniProtKB/Swiss-Prot: P33897 source 1..280 mol_type protein organism Homo sapiens GPLKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQILGEAVAPAHVPAPSPQGPG 293 AA PAT REGION 1..293 note Description of sequence: Nucleotide binding domain of ABCE1 gene product from UniProtKB/Swiss-Prot: P61221 source 1..293 mol_type protein organism Homo sapiens GALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF 228 AA PAT REGION 1..228 note Description of sequence: Nucleotide binding domain of the ABCF1 gene product from UniProtKB - Q8NE71 source 1..228 mol_type protein organism Homo sapiens PPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE 269 AA PAT REGION 1..269 note Description of sequence: Nucleotide binding domain of the ABCG2 gene product from UniProtKB/Swiss-Prot: P45844 source 1..269 mol_type protein organism Homo sapiens RFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEY 748 AA PAT REGION 1..748 note Description of sequence: TAP1 NCBI NP_000584.3 source 1..748 mol_type protein organism Homo sapiens MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE 257 AA PAT REGION 1..257 note Description of sequence: A nucleotide binding domain polypeptide of wild type TAP1 source 1..257 mol_type protein organism Homo sapiens GLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE 257 AA PAT REGION 1..257 note Description of sequence: A nucleotide binding domain polypeptide based on TAP1 source 1..257 mol_type protein organism Homo sapiens GLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPSVLILDNATSALDAGNQLRVQRLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGSYWAMVQAPADAPE 686 AA PAT REGION 1..686 note Description of sequence: Tap2 UniProtKB - Q03519 source 1..686 mol_type protein organism Homo sapiens MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL 226 AA PAT REGION 1..226 note Description of sequence: A nucleotide binding domain polypeptide of wild type TAP2 source 1..226 mol_type protein organism Homo sapiens GTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQK 1480 AA PAT REGION 1..1480 note Description of sequence: NCBI Accession ABD72215.1 source 1..1480 mol_type protein organism Homo sapiens MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 200 AA PAT REGION 1..200 note Description of sequence: A nucleotide binding domain polypeptide of the CFTR source 1..200 mol_type protein organism Homo sapiens VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPD 229 AA PAT REGION 1..229 note Description of sequence: A nucleotide binding domain polypeptide of the CFTR source 1..229 mol_type protein organism Homo sapiens VARIANT 1..229 note position 2 may be absent or L; position 229 is absent or G VARIANT 2 note position 2 may be absent VARIANT 229 note position 229 may be absent SLTTTEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMG 4 AA PAT REGION 1..4 note Description of sequence: Linker sequence source 1..4 mol_type protein organism Homo sapiens GGGS 8 AA PAT REGION 1..8 note Description of sequence: Linker sequence source 1..8 mol_type protein organism Homo sapiens GGGSGGGS 12 AA PAT REGION 1..12 note Description of sequence: Linker sequence source 1..12 mol_type protein organism Homo sapiens GGGSGGGSGGGS 16 AA PAT REGION 1..16 note Description of sequence: Linker sequence source 1..16 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGS 20 AA PAT REGION 1..20 note Description of sequence: Linker sequence source 1..20 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGS 24 AA PAT REGION 1..24 note Description of sequence: Linker sequence source 1..24 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGSGGGS 24 AA PAT REGION 1..24 note Description of sequence: Linker sequence source 1..24 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGSGGGS 24 AA PAT REGION 1..24 note Description of sequence: Linker sequence source 1..24 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGSGGGS 28 AA PAT REGION 1..28 note Description of sequence: Linker sequence source 1..28 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGSGGGSGGGS 32 AA PAT REGION 1..32 note Description of sequence: Linker sequence source 1..32 mol_type protein organism Homo sapiens GGGSGGGSGGGSGGGSGGGSGGGSGGGSGGGS 5 AA PAT REGION 1..5 note Description of sequence: Linker sequence source 1..5 mol_type protein organism Homo sapiens GGGGS 10 AA PAT REGION 1..10 note Description of sequence: Linker sequence source 1..10 mol_type protein organism Homo sapiens GGGGSGGGGS 15 AA PAT REGION 1..15 note Description of sequence: Linker sequence source 1..15 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGS 20 AA PAT REGION 1..20 note Description of sequence: Linker sequence source 1..20 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGS 25 AA PAT REGION 1..25 note Description of sequence: Linker sequence source 1..25 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGS 30 AA PAT REGION 1..30 note Description of sequence: Linker sequence source 1..30 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 35 AA PAT REGION 1..35 note Description of sequence: Linker sequence source 1..35 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 40 AA PAT REGION 1..40 note Description of sequence: Linker sequence source 1..40 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 45 AA PAT REGION 1..45 note Description of sequence: Linker sequence source 1..45 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 50 AA PAT REGION 1..50 note Description of sequence: Linker sequence source 1..50 mol_type protein organism Homo sapiens GGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGGGGS 7 AA PAT REGION 1..7 note Description of sequence: Linker sequence source 1..7 mol_type protein organism Homo sapiens VARIANT 1..7 note position 1 may be absent or any alanine; position 7 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 7 note position 7 may be absent AEAAAKA 12 AA PAT REGION 1..12 note Description of sequence: Linker sequence source 1..12 mol_type protein organism Homo sapiens VARIANT 1..12 note position 1 may be absent or any alanine; position 12 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 12 note position 12 may be absent AEAAAKEAAAKA 17 AA PAT REGION 1..17 note Description of sequence: Linker sequence source 1..17 mol_type protein organism Homo sapiens VARIANT 1..17 note position 1 may be absent or any alanine; position 17 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 17 note position 17 may be absent AEAAAKEAAAKEAAAKA 22 AA PAT REGION 1..22 note Description of sequence: Linker sequence source 1..22 mol_type protein organism Homo sapiens VARIANT 1..22 note position 1 may be absent or any alanine; position 22 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 22 note position 22 may be absent AEAAAKEAAAKEAAAKEAAAKA 27 AA PAT REGION 1..27 note Description of sequence: Linker sequence source 1..27 mol_type protein organism Homo sapiens VARIANT 1..27 note position 1 may be absent or any alanine; position 27 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 27 note position 27 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKA 33 AA PAT REGION 1..33 note Description of sequence: Linker sequence source 1..33 mol_type protein organism Homo sapiens VARIANT 1..33 note position 1 may be absent or any alanine; position 32 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 33 note position 33 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKKEAAAKA 37 AA PAT REGION 1..37 note Description of sequence: Linker sequence source 1..37 mol_type protein organism Homo sapiens VARIANT 1..37 note position 1 may be absent or any alanine; position 37 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 37 note position 37 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 42 AA PAT REGION 1..42 note Description of sequence: Linker sequence source 1..42 mol_type protein organism Homo sapiens VARIANT 1..42 note position 1 may be absent or any alanine; position 42 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 42 note position 42 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 47 AA PAT REGION 1..47 note Description of sequence: Linker sequence source 1..47 mol_type protein organism Homo sapiens VARIANT 1..47 note position 1 may be absent or any alanine; position 47 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 47 note position 47 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 52 AA PAT REGION 1..52 note Description of sequence: Linker sequence source 1..52 mol_type protein organism Homo sapiens VARIANT 1..52 note position 1 may be absent or any alanine; position 52 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 52 note position 52 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 57 AA PAT REGION 1..57 note Description of sequence: Linker sequence source 1..57 mol_type protein organism Homo sapiens VARIANT 1..57 note position 1 may be absent or any alanine; position 57 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 57 note position 57 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 62 AA PAT REGION 1..62 note Description of sequence: Linker sequence source 1..62 mol_type protein organism Homo sapiens VARIANT 1..62 note position 1 may be absent or any alanine; position 62 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 62 note position 62 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 67 AA PAT REGION 1..67 note Description of sequence: Linker sequence source 1..67 mol_type protein organism Homo sapiens VARIANT 1..67 note position 1 may be absent or any alanine; position 67 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 67 note position 67 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 72 AA PAT REGION 1..72 note Description of sequence: Linker sequence source 1..72 mol_type protein organism Homo sapiens VARIANT 1..72 note position 1 may be absent or any alanine; position 72 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 72 note position 72 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 77 AA PAT REGION 1..77 note Description of sequence: Linker sequence source 1..77 mol_type protein organism Homo sapiens VARIANT 1..77 note position 1 may be absent or any alanine; position 77 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 77 note position 77 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 82 AA PAT REGION 1..82 note Description of sequence: Linker sequence source 1..82 mol_type protein organism Homo sapiens VARIANT 1..82 note position 1 may be absent or any alanine; position 82 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 82 note position 82 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 87 AA PAT REGION 1..87 note Description of sequence: Linker sequence source 1..87 mol_type protein organism Homo sapiens VARIANT 1..87 note position 1 may be absent or any alanine; position 87 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 87 note position 87 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 92 AA PAT REGION 1..92 note Description of sequence: Linker sequence source 1..92 mol_type protein organism Homo sapiens VARIANT 1..92 note position 1 may be absent or any alanine; position 92 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 92 note position 92 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 97 AA PAT REGION 1..97 note Description of sequence: Linker sequence source 1..97 mol_type protein organism Homo sapiens VARIANT 1..97 note position 1 may be absent or any alanine; position 97 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 97 note position 97 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 102 AA PAT REGION 1..102 note Description of sequence: Linker sequence source 1..102 mol_type protein organism Homo sapiens VARIANT 1..102 note position 1 may be absent or any alanine; position 102 is absent or alanine VARIANT 1 note position 1 may be absent VARIANT 102 note position 102 may be absent AEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKEAAAKA 227 AA PAT REGION 1..227 note Description of sequence: WT Homo sapiens IgG1 Fc Sequence source 1..227 mol_type protein organism Homo sapiens DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 226 AA PAT REGION 1..226 note Description of sequence: hIgG1 Fc with LALA substitution source 1..226 mol_type protein organism Homo sapiens DKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 325 AA PAT REGION 1..325 note Description of sequence: Homo sapiens IgG2 Fc GenBank AAN76044 source 1..325 mol_type protein organism Homo sapiens STKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 246 AA PAT REGION 1..246 note Description of sequence: Homo sapiens IgG3 Fc GenBank AAW65947 source 1..246 mol_type protein organism Homo sapiens HKPSNTKVDKRVELKTPLGDTTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 223 AA PAT REGION 1..223 note Description of sequence: Homo sapiens IgG4 Fc Segment source 1..223 mol_type protein organism Homo sapiens PPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSPG 253 AA PAT REGION 1..253 note Description of sequence: A scFv anti-human CD3 source 1..253 mol_type protein organism Homo sapiens AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVTTYADSVKGRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 253 AA PAT REGION 1..253 note Description of sequence: A scFv anti-human CD3 source 1..253 mol_type protein organism Homo sapiens AIQMTQSPSSLSASVGDRVTITCRASQDIRNYLNWYQQKPGKAPKLLIYYTSRLESGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQGNTLPWTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSGGGSEVQLVESGGGLVQPGGSLRLSCAASGYSFTGYTMNWVRQAPGKGLEWVALINPYKGVSTYNQKFKDRFTISVDKSKNTAYLQMNSLRAEDTAVYYCARSGYYGDSDWYFDVWGQGTLVTVSS 115 AA PAT REGION 1..115 note Description of sequence: An anti-human CD3 VHH source 1..115 mol_type protein organism Homo sapiens QVQLVESGGGLVQPGGSLRLSCAASGSIFSANTMGWYRQAPGKQRELVAGMNTSGSTVYGDSVKGRFTISRDNAKNIAYLQMNSLIPEDTAVYYCTLVQRGPNYWGQGTQVTVSS 240 AA PAT REGION 1..240 note Description of sequence: An anti-human CD3 scFv (vH-vL) source 1..240 mol_type protein organism Homo sapiens DVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGQGLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGGGTKVEIK 240 AA PAT REGION 1..240 note Description of sequence: An anti-human CD3 scFv (vH-vL) with disulfide linkage source 1..240 mol_type protein organism Homo sapiens DISULFID 43..233 note Disufide bond between POS 43 and POS 233 DVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGCGLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGCGTKVEIK 240 AA PAT REGION 1..240 note Description of sequence: An anti-human CD3 scFv (vH-vL) with disulfide linkage source 1..240 mol_type protein organism Homo sapiens DISULFID 43..234 note Disufide bond between POS 43 and POS 234 DVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGCGLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGGCTKVEIK 240 AA PAT REGION 1..240 note Description of sequence: An anti-human CD3 scFv (vH-vL) with disulfide linkage source 1..240 mol_type protein organism Homo sapiens DISULFID 44..233 note Disufide bond between POS 44 and POS 233 DVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGQCLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGCGTKVEIK 240 AA PAT REGION 1..240 note Description of sequence: An anti-human CD3 scFv (vH-vL) with disulfide linkage source 1..240 mol_type protein organism Homo sapiens DISULFID 44..234 note Disufide bond between POS 44 and POS 234 DVQLVQSGAEVKKPGASVKVSCKASGYTFTRYTMHWVRQAPGQCLEWIGYINPSRGYTNYADSVKGRFTITTDKSTSTAYMELSSLRSEDTATYYCARYYDDHYCLDYWGQGTTVTVSSGGGGSGGGGSGGGGSDIVLTQSPATLSLSPGERATLSCRASQSVSYMNWYQQKPGKAPKRWIYDTSKVASGVPARFSGSGSGTDYSLTINSLEAEDAATYYCQQWSSNPLTFGGCTKVEIK 24 DNA PAT source 1..24 mol_type other DNA organism synthetic construct misc_feature 1..24 note Description of sequence: Enzyme:Oligonucleotide IMT504 tcatcattttgtcattttgtcatt 240 AA PAT REGION 1..240 note Description of sequence: An anti-mesothelin scFv polypeptide related to the murine-derived SS1 antibody source 1..240 mol_type protein organism Homo sapiens VARIANT 121 note X is V or G QVQLQQSGPELEKPGASVKISCKASGYSFTGYTMNWVKQSHGKSLEWIGLITPYNGASSYNQKFRGKATLTVDKSSSTAYMDLLSLTSEDSAVYFCARGGYDGRGFDYWGSGTPVTVSSGXGGSGGGGSGGGGSDIELTQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDTSKLASGVPGRFSGSGSGNSYSLTISSVEAEDDATYYCQQWSKHPLTFGSGTKVEIK 244 AA PAT REGION 1..244 note Description of sequence: An anti-human mesothelin scFv (vH-vL) polypeptide related to the monoclonal antibody YP218 source 1..244 mol_type protein organism Homo sapiens VARIANT 121 note X is V or G QEQLVESGGGLVQPGASLTLTCTASGIDFSRYYMCWVRQAPGKGLEGIACIYIGGSGSTYYASWAKGRFTISKASSTTVTLQMTSLTAADTATYFCARGTNLNYIFRLWGPGTLVTVSSGXGGSGGGGSGGGGSDVVMTQTPASVSEPVGGTVTIKCQASQRISSYLSWYQQKPGQRPKLLIFGASTLASGVPSRFKGSGSGTEYTLTISDLECADAATYYCQSYAYFDSNNWHAFGGGTEVVV 244 AA PAT REGION 1..244 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody YP218 source 1..244 mol_type protein organism Homo sapiens VARIANT 112 note X is V or G DVVMTQTPASVSEPVGGTVTIKCQASQRISSYLSWYQQKPGQRPKLLIFGASTLASGVPSRFKGSGSGTEYTLTISDLECADAATYYCQSYAYFDSNNWHAFGGGTEVVVGXGGSGGGGSGGGGSQEQLVESGGGLVQPGASLTLTCTASGIDFSRYYMCWVRQAPGKGLEGIACIYIGGSGSTYYASWAKGRFTISKASSTTVTLQMTSLTAADTATYFCARGTNLNYIFRLWGPGTLVTVSS 239 AA PAT REGION 1..239 note Description of sequence: An anti-human mesothelin scFv (vH-vL) polypeptide related to the monoclonal antibody 15B6 source 1..239 mol_type protein organism Homo sapiens VARIANT 116 note X is V or G EVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGKSLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVSSGXGGSGGGGSGGGGSQAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGGGTKLTVLG 239 AA PAT REGION 1..239 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody 15B6 source 1..239 mol_type protein organism Homo sapiens VARIANT 112 note X is V or G QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGGGTKLTVLGGXGGSGGGGSGGGGSEVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGKSLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVSS 239 AA PAT REGION 1..239 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody 15B6 with a disulfide linkage source 1..239 mol_type protein organism Homo sapiens DISULFID 102..168 note Disulfide bond between POS 102 and POS 168 QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGCGTKLTVLGGGGGSGGGGSGGGGSEVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGCSLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVSS 239 AA PAT REGION 1..239 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody 15B6 with a disulfide linkage source 1..239 mol_type protein organism Homo sapiens DISULFID 102..169 note Disulfide bond between POS 102 and POS 169 QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGCGTKLTVLGGGGGSGGGGSGGGGSEVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGKCLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVSS 239 AA PAT REGION 1..239 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody 15B6 with a disulfide linkage source 1..239 mol_type protein organism Homo sapiens DISULFID 103..168 note Disulfide bond between POS 103 and POS 168 QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGGCTKLTVLGGGGGSGGGGSGGGGSEVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGCSLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVSS 238 AA PAT REGION 1..238 note Description of sequence: An anti-human mesothelin scFv (vL-vH) polypeptide related to the monoclonal antibody 15B6 with a disulfide linkage source 1..238 mol_type protein organism Homo sapiens DISULFID 103..169 note Disulfide bond between POS 103 and POS 169 QAVVTQESALTTSPGETVTLTCRSSTGAVTTGNYPNWVQEKPDHLFTGLIAGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWFSSHWVFGGCTKLTVLGGGGGSGGGGSGGGGSEVQLQQSGPVLVKPGASVKISCKASGYSFTGYYMHWVRQSNGKCLEWIGRINPYTGVPSYKHNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARELGGYWGQGTTLTVS 113 AA PAT REGION 1..113 note Description of sequence: An anti-human mesothelin (VHH) polypeptide related to the monoclonal antibody SD1 source 1..113 mol_type protein organism Homo sapiens QVQLVQSGGGLVQPGGSLRLSCAASDFDFAAYEMSWVRQAPGQGLEWVAIISHDGIDKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTATYYCLRLGAVGQGTLVTVSSS 252 AA PAT REGION 1..252 note Description of sequence: An anti-human EpCAM scFv (vH-vL) polypeptide related to the monoclonal antibody MT201 source 1..252 mol_type protein organism Homo sapiens VARIANT 129 note X is V or G EVQLLESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDMGWGSGWRPYYYYGMDVWGQGTTVTVSSGXGGSGGGGSGGGGSELQMTQSPSSLSASVGDRVTITCRTSQSISSYLNWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQPEDSATYYCQQSYDIPYTFGQGTKLEIKRTV 252 AA PAT REGION 1..252 note Description of sequence: An anti-human EpCAM scFv (vL-vH) polypeptide related to the monoclonal antibody MT201 source 1..252 mol_type protein organism Homo sapiens VARIANT 112 note X is V or G ELQMTQSPSSLSASVGDRVTITCRTSQSISSYLNWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQPEDSATYYCQQSYDIPYTFGQGTKLEIKRTVGXGGSGGGGSGGGGSEVQLLESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDMGWGSGWRPYYYYGMDVWGQGTTVTVSS 242 AA PAT REGION 1..242 note Description of sequence: An anti-human CTLA-4 scFv (vL-vH) polypeptide related to Ipilimumab source 1..242 mol_type protein organism Homo sapiens EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Description of sequence: An anti-human CTLA-4 scFv (vL-vH) polypeptide related to Ipilimumab with a disulfide linkage source 1..242 mol_type protein organism Homo sapiens DISULFID 101..167 note Disulfide bond between POS 101 and POS 167 EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGCGTKVEIKRGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGCGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Description of sequence: An anti-human CTLA-4 scFv (vL-vH) polypeptide related to Ipilimumab with a disulfide linkage source 1..242 mol_type protein organism Homo sapiens DISULFID 101..168 note Disulfide bond between POS 101 and POS 168 EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGCGTKVEIKRGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKCLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Description of sequence: An anti-human CTLA-4 scFv (vL-vH) polypeptide related to Ipilimumab with a disulfide linkage source 1..242 mol_type protein organism Homo sapiens DISULFID 102..167 note Disulfide bond between POS 102 and POS 167 EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQCTKVEIKRGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGCGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 242 AA PAT REGION 1..242 note Description of sequence: An anti-human CTLA-4 scFv (vL-vH) polypeptide related to Ipilimumab with a disulfide linkage source 1..242 mol_type protein organism Homo sapiens DISULFID 102..168 note Disulfide bond between POS 102 and POS 168 EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQCTKVEIKRGGGGSGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKCLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS 261 AA PAT REGION 1..261 note Description of sequence: A nucleotide binding domain polypeptide based on TAP1 source 1..261 mol_type protein organism Homo sapiens MPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPSVLILDNATSALDAGNQLRVQRLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGSYWAMVQAPADAPE 290 AA PAT REGION 1..290 note Description of sequence: A nucleotide binding domain polypeptide based on TAP1 source 1..290 mol_type protein organism Homo sapiens METEFFQQNQTGGGGSGLQTVRSFGGGGGSGGSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPSVLILDNATSALDAGNQLRVQRLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGSYWAMVQAPADAPE 247 AA PAT REGION 1..247 note Description of sequence: anti-CD28 scFv source 1..247 mol_type protein organism Homo sapiens DIELTQSPASLAVSLGQRATISCRASESVEYYVTSLMQWYQQKPGQPPKLLIFAASNVESGVPARFSGSGSGTNFSLNIHPVDEDDVAMYFCQQSRKVPYTFGGGTKLEIKRGGGGSGGGGSGGGGSQVKLQQSGPGLVTPSQSLSITCTVSGFSLSDYGVHWVRQSPGQGLEWLGVIWAGGGTNYNSALMSRKSISKDNSKSQVFLKMNSLQADDTAVYYCARDKGYSYYYSMDYWGQGTTVTVSS 518 AA PAT REGION 1..518 note Description of sequence: Single-chain IL12 source 1..518 mol_type protein organism Homo sapiens IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCSGGGGSGGGGSGGGGSRNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 306 AA PAT REGION 1..306 note Description of sequence: IL12 component p40 source 1..306 mol_type protein organism Homo sapiens IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS 197 AA PAT REGION 1..197 note Description of sequence: IL12 component p35 source 1..197 mol_type protein organism Homo sapiens RNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 645 AA PAT REGION 1..645 note Description of sequence: single chain 4-1BBL (trimer) source 1..645 mol_type protein organism Homo sapiens ACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSEGGGGSGGGGSGGGGSACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSEGGGGSGGGGSGGGGSACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE 205 AA PAT REGION 1..205 note Description of sequence: a 4-1BBL amino acid sequence source 1..205 mol_type protein organism Homo sapiens ACPWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE 468 AA PAT REGION 1..468 note Description of sequence: a single-chain CD40L (sequence trimer) source 1..468 mol_type protein organism Homo sapiens GDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKLGGGGSGGGGSGGGGSGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKLGGGGSGGGGSGGGGSGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL 146 AA PAT REGION 1..146 note Description of sequence: a CD40L amino acid sequence source 1..146 mol_type protein organism Homo sapiens GDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL 265 AA PAT REGION 1..265 note Description of sequence: Single-chain IFNg (monomeric engagement) source 1..265 mol_type protein organism Homo sapiens MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIDELIQVMAEFSTEEQQEGPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRG 119 AA PAT REGION 1..119 note Description of sequence: Anti-CD16 VHH source 1..119 mol_type protein organism Homo sapiens EVQLVESGGGLVQPGESLTLSCVVAGSIFSFAMSWYRQAPGKERELVARIGSDDRVTYADSVKGRFTISRDNIKRTAGLQMNSLKPEDTAVYYCNAQTDLRDWTVREYWGQGTQVTVSS 201 AA PAT REGION 1..201 note Description of sequence: a CD80 amino acid sequence source 1..201 mol_type protein organism Homo sapiens VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTK 222 AA PAT REGION 1..222 note Description of sequence: CD86 (IgV-IgC) source 1..222 mol_type protein organism Homo sapiens LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMNRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIP 109 AA PAT REGION 1..109 note Description of sequence: CD86 (IGV) source 1..109 mol_type protein organism Homo sapiens LKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLA 482 AA PAT REGION 1..482 note Description of sequence: scFc (wild type L234 L235; including Fc hinge source 1..482 mol_type protein organism Homo sapiens DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGSGGGGSGGGGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 122 AA PAT REGION 1..122 note Description of sequence: Anti-CD16 VHH source 1..122 mol_type protein organism Homo sapiens EVQLVESGGELVQPGGSLRLSCAASGLTFSSYNMGWFRRAPGKEREFVASITWSGRDTFYADSVKGRFTISRDNAKNTVYLQMSSLKPEDTAVYYCAANPWPVAAPRSGTYWGQGTQVTVSS