CN 217334 1PCWO CN 202210113320.2 2022-01-30 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences C-TERMINAL FRAGMENT OF APOLIPOPROTEIN E AND APPLICATION THEREOF IN INHIBITING γ-SECRETASE ACTIVITY 100 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct agagcaacatctggggacaaa 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct tccacaaataggttggccagat 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct gctctgggagagccaacata 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct aacgaattggctttgctgtca 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct aggctatggtcatgagggttg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tgactctctgcatggtggtg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tcagaattgagtgcagggct 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tttgagcctcccttgactgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct ggtattccagtccccgctg 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gattatctaatggacgacccc 21 RNA PAT source 1..21 mol_type other RNA organism synthetic construct gcgtgcttcgctccgtatttg 299 AA PAT source 1..299 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKCLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 85 AA PAT source 1..85 mol_type protein organism synthetic construct RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 86 AA PAT source 1..86 mol_type protein organism synthetic construct LRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 87 AA PAT source 1..87 mol_type protein organism synthetic construct RLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 88 AA PAT source 1..88 mol_type protein organism synthetic construct ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 89 AA PAT source 1..89 mol_type protein organism synthetic construct GERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 83 AA PAT source 1..83 mol_type protein organism synthetic construct RMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 82 AA PAT source 1..82 mol_type protein organism synthetic construct MEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 81 AA PAT source 1..81 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 80 AA PAT source 1..80 mol_type protein organism synthetic construct EMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 79 AA PAT source 1..79 mol_type protein organism synthetic construct MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 79 AA PAT source 1..79 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPV 74 AA PAT source 1..74 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGT 71 AA PAT source 1..71 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGT 70 AA PAT source 1..70 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVG 69 AA PAT source 1..69 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAV 68 AA PAT source 1..68 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAA 67 AA PAT source 1..67 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQA 66 AA PAT source 1..66 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQ 61 AA PAT source 1..61 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGL 56 AA PAT source 1..56 mol_type protein organism synthetic construct EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 60 AA PAT source 1..60 mol_type protein organism synthetic construct EMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGL 16 AA PAT source 1..16 mol_type protein organism synthetic construct RQIKIWFQNRRMKWKK 11 AA PAT source 1..11 mol_type protein organism synthetic construct YGRKKRRQRRR 8 AA PAT source 1..8 mol_type protein organism synthetic construct KQAIPVAK 15 AA PAT source 1..15 mol_type protein organism synthetic construct RRRRNRTRRNRRRVR 21 AA PAT source 1..21 mol_type protein organism synthetic construct KLTRAQRRAAARKNKRNTRGC 21 AA PAT source 1..21 mol_type protein organism synthetic construct ALWKTLLKKVLKAPKKKRKVC 9 AA PAT source 1..9 mol_type protein organism synthetic construct RKKRRQRRR 34 AA PAT source 1..34 mol_type protein organism synthetic construct DAATATRGRSAASRPTERPRAPARSASRPRRPVE 27 AA PAT source 1..27 mol_type protein organism synthetic construct GWTLNSAGYLLGKINLKALAALAKKIL 21 AA PAT source 1..21 mol_type protein organism synthetic construct AGYLLGKINLKALAALAKKIL 16 AA PAT source 1..16 mol_type protein organism synthetic construct YTAIAWVKAFIRKLRK 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEAVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAAAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRAWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLAEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAAGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVASDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIALQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRARDRLAEVKEAVAEVAAKLEAQAQQARLQAAAFQAALKSWAEPLVADMQRAWAGLAEKVQAAVGTAAAPVASDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRARDRLDEVKEAVAEVRAKLEAQAQQIRLQAAAFQARLKSWAEPLVEDMQRAWAGLVEKVQAAVGTSAAPVASDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEAVAEVRAKLEEQAQQIRLQAAAFQARLKSWFEPLVEDMQRAWAGLVEKVQAAVGTSAAPVASDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct AAAAAMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTAAAAAAAAAA 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTAAAAAEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAAAAAALEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 331 AA PAT source 1..331 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKCLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRGSGGSDYKDHDGDYKDHDIDYKDDDDKSGSGSARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 288 AA PAT source 1..288 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKCLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 84 AA PAT source 1..84 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQISLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGASTAPVPSDNH 9 AA PAT source 1..9 mol_type protein organism synthetic construct RRRRRRRRR 12 AA PAT source 1..12 mol_type protein organism synthetic construct AAVLLPVLLAAP 39 AA PAT source 1..39 mol_type protein organism synthetic construct KSVRTWNEIIPSKGCLRVGGRCHPHVNGGGRRRRRRRRR 18 AA PAT source 1..18 mol_type protein organism synthetic construct MKVLWAALLVTFLAGCQA 18 AA PAT source 1..18 mol_type protein organism synthetic construct MKAAVLTLAVLFLTGSQA 22 AA PAT source 1..22 mol_type protein organism synthetic construct MMKTLLLFVGLLLTWESGQVLG 4 AA PAT source 1..4 mol_type protein organism synthetic construct SGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct GSSGS 4 AA PAT source 1..4 mol_type protein organism synthetic construct GGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGGGS 5 AA PAT source 1..5 mol_type protein organism synthetic construct SSSSG 5 AA PAT source 1..5 mol_type protein organism synthetic construct GSGSA 5 AA PAT source 1..5 mol_type protein organism synthetic construct GGSGG 73 AA PAT source 1..73 mol_type protein organism synthetic construct ARMEEMGSRTRDRLDEVKEQVAEVRAKLEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 32 AA PAT source 1..32 mol_type protein organism synthetic construct GSGGSDYKDHDGDYKDHDIDYKDDDDKSGSGS 54 AA PAT source 1..54 mol_type protein organism synthetic construct MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 167 AA PAT source 1..167 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKCLAVYQAGAR 38 AA PAT source 1..38 mol_type protein organism synthetic construct EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 205 AA PAT source 1..205 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKCLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 14 AA PAT source 1..14 mol_type protein organism synthetic construct GKPIPNPLLGLDST 9 AA PAT source 1..9 mol_type protein organism synthetic construct IPNPLLGLD 10 AA PAT source 1..10 mol_type protein organism synthetic construct RRRRRRRRRR 11 AA PAT source 1..11 mol_type protein organism synthetic construct RRRRRRRRRRR 12 AA PAT source 1..12 mol_type protein organism synthetic construct RRRRRRRRRRRR 55 AA PAT source 1..55 mol_type protein organism synthetic construct EMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 8 AA PAT source 1..8 mol_type protein organism synthetic construct GGGSGGGS 299 AA PAT source 1..299 mol_type protein organism Homo sapiens KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH 167 AA PAT source 1..167 mol_type protein organism synthetic construct KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAR 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct attatctaatggacgacccc 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct caaatacggagcgaagcacg 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct agagcaacatctggggacaaa 22 DNA PAT source 1..22 mol_type other DNA organism synthetic construct tccacaaataggttggccagat 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct aacgaattggctttgctgtc 21 DNA PAT source 1..21 mol_type other DNA organism synthetic construct aggctatggtcatgagggttg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tgactctctgcatggtggtg 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tcagaattgagtgcagggct 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct tttgagcctcccttgactgg 19 DNA PAT source 1..19 mol_type other DNA organism synthetic construct ggtattccagtccccgctg