US PCT/US22/44765 2022-09-26 2010581-1149 US US 63/248,520 2021-09-26 WAVE LIFE SCIENCES LTD. OLIGONUCLEOTIDES COMPOSITIONS AND METHODS OR USE THEREOF 28 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46312 misc_feature 1..30 note Synthetic: ADR-0100541 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-44515 misc_feature 1..30 note Synthetic: ADR-0104180 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-47606 misc_feature 1..30 note Synthetic: ADR-0100564 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46460 misc_feature 1..30 note Synthetic: ADR-0104089 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-47608 misc_feature 1..30 note Synthetic: ADR-0100566 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base gm modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-47037 misc_feature 1..30 note Synthetic: ADR-0104273 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base gm modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49085 misc_feature 1..30 note Synthetic: ADR-0100585 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base gm modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49086 misc_feature 1..30 note Synthetic: ADR-0100586 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base gm modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49087 misc_feature 1..30 note Synthetic: ADR-0100587 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base cm modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base um modified_base 16 mod_base cm modified_base 17 mod_base cm modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49088 misc_feature 1..30 note Synthetic: ADR-0100588 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base cm modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base um modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 17 mod_base cm modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-50496 misc_feature 1..30 note Synthetic: ADR-0104091 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base cm modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base um modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 17 mod_base cm modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49089 misc_feature 1..30 note Synthetic: ADR-0100589 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base um modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 17 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49090 misc_feature 1..30 note Synthetic: ADR-0100590 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base cm modified_base 19 mod_base um modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-50497 misc_feature 1..30 note Synthetic: ADR-0104090 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 11 mod_base um modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base cm modified_base 19 mod_base um modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-49092 misc_feature 1..30 note Synthetic: ADR-0100592 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-50498 misc_feature 1..30 note Synthetic: ADR-0104087 modified_base 1 mod_base cm modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 7 mod_base OTHER note 2-O-methoxyethylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base OTHER note 2-O-methoxyethylribose 5-methyl-cytidine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 21 mod_base OTHER note 2-O-methoxyethylribose thymine modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-44464 misc_feature 1..30 note Synthetic: ADR-0100529 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-fluororibose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-fluororibose uracil modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base OTHER note 2-fluororibose cytosine modified_base 12..13 mod_base OTHER note S-phosphorothioate modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 15..16 mod_base OTHER note S-phosphorothioate modified_base 16 mod_base OTHER note 2-fluororibose cytosine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base OTHER note 2-fluororibose uracil modified_base 21..22 mod_base OTHER note S-phosphorothioate modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note 2-fluororibose uracil modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose 6-amino-9-substituted 8,9-dihydro-7H-purin-8-one modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttctagtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46323 misc_feature 1..30 note Synthetic: ADR-0100552 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-fluororibose cytosine modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base OTHER note 2-fluororibose uracil modified_base 20..21 mod_base OTHER note S-phosphorothioate modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46313 misc_feature 1..30 note Synthetic: ADR-0100542 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46314 misc_feature 1..30 note Synthetic: ADR-0100543 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 20..21 mod_base OTHER note S-phosphorothioate modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46315 misc_feature 1..30 note Synthetic: ADR-0100544 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-fluororibose uracil modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base OTHER note 2-fluororibose cytosine modified_base 12..13 mod_base OTHER note S-phosphorothioate modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 17 mod_base cm modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 21..22 mod_base OTHER note S-phosphorothioate modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46316 misc_feature 1..30 note Synthetic: ADR-0100545 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-fluororibose uracil modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base OTHER note 2-fluororibose cytosine modified_base 12..13 mod_base OTHER note S-phosphorothioate modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 15..16 mod_base OTHER note S-phosphorothioate modified_base 16 mod_base OTHER note 2-fluororibose cytosine modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 21..22 mod_base OTHER note S-phosphorothioate modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46317 misc_feature 1..30 note Synthetic: ADR-0100546 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46318 misc_feature 1..30 note Synthetic: ADR-0100547 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46319 misc_feature 1..30 note Synthetic: ADR-0100548 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base cm modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46320 misc_feature 1..30 note Synthetic: ADR-0100549 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-fluororibose cytosine modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base cm modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base OTHER note 2-fluororibose cytosine modified_base 17..18 mod_base OTHER note S-phosphorothioate modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-fluororibose uracil modified_base 20..21 mod_base OTHER note S-phosphorothioate modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46321 misc_feature 1..30 note Synthetic: ADR-0100550 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base OTHER note 2-fluororibose cytosine modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 7..8 mod_base OTHER note S-phosphorothioate modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 10 mod_base um modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base cm modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 13..14 mod_base OTHER note S-phosphorothioate modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 16..17 mod_base OTHER note S-phosphorothioate modified_base 17 mod_base cm modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 20 mod_base OTHER note 2-fluororibose uracil modified_base 20..21 mod_base OTHER note S-phosphorothioate modified_base 21 mod_base um modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat 30 RNA PAT misc_feature 1..30 note Synthetic: WV-46322 misc_feature 1..30 note Synthetic: ADR-0100551 modified_base 1 mod_base OTHER note triantennary GalNAc with C12 linker linked to 6-aminohexanol linked by phosphate to the 5' end of 2-O-methylribose cytosine modified_base 1..2 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 2 mod_base cm modified_base 2..3 mod_base OTHER note S-phosphorothioate modified_base 3 mod_base cm modified_base 3..4 mod_base OTHER note S-phosphorothioate modified_base 4 mod_base OTHER note 2-fluororibose adenine modified_base 4..5 mod_base OTHER note S-phosphorothioate modified_base 5 mod_base OTHER note 2-fluororibose guanine modified_base 5..6 mod_base OTHER note S-phosphorothioate modified_base 6 mod_base cm modified_base 7 mod_base OTHER note 2-O-methylribose adenine modified_base 8 mod_base OTHER note 2-fluororibose guanine modified_base 8..9 mod_base OTHER note S-phosphorothioate modified_base 9 mod_base OTHER note 2-fluororibose cytosine modified_base 9..10 mod_base OTHER note S-phosphorothioate modified_base 10 mod_base OTHER note 2-fluororibose uracil modified_base 10..11 mod_base OTHER note S-phosphorothioate modified_base 11 mod_base OTHER note 2-fluororibose uracil modified_base 11..12 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 12 mod_base OTHER note 2-fluororibose cytosine modified_base 12..13 mod_base OTHER note S-phosphorothioate modified_base 13 mod_base OTHER note 2-fluororibose adenine modified_base 14 mod_base OTHER note 2-fluororibose guanine modified_base 14..15 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 15 mod_base OTHER note 2-fluororibose uracil modified_base 16 mod_base cm modified_base 17 mod_base cm modified_base 18 mod_base OTHER note 2-fluororibose cytosine modified_base 18..19 mod_base OTHER note S-phosphorothioate modified_base 19 mod_base OTHER note 2-fluororibose uracil modified_base 19..20 mod_base OTHER note S-phosphorothioate modified_base 20 mod_base um modified_base 21 mod_base um modified_base 21..22 mod_base OTHER note S-phosphorothioate modified_base 22 mod_base OTHER note 2-fluororibose cytosine modified_base 22..23 mod_base OTHER note S-phosphorothioate modified_base 23 mod_base OTHER note deoxyribose thymine modified_base 23..24 mod_base OTHER note S-phosphorothioate modified_base 24 mod_base OTHER note deoxyribose uracil (position 3 connectivity) modified_base 24..25 mod_base OTHER note S-phosphorothioate modified_base 25 mod_base OTHER note deoxyribose inosine modified_base 25..26 mod_base OTHER note S-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 26 mod_base um modified_base 27 mod_base OTHER note 2-fluororibose cytosine modified_base 27..28 mod_base OTHER note S-phosphorothioate modified_base 28 mod_base gm modified_base 28..29 mod_base OTHER note S-phosphorothioate modified_base 29 mod_base OTHER note 2-O-methylribose adenine modified_base 29..30 mod_base OTHER note R-N-(1,3-dimethylimidazolidin-2-ylidene)phosphoramidate modified_base 30 mod_base um source 1..30 mol_type other RNA organism synthetic construct cccagcagcttcagtccctttcttgtcgat