IEC240373PCT CN 202311307741.X 2023-10-10 SHANGHAI SCIZENG MEDICAL TECHNOLOGY CO., LTD. ANTI-PD-1 MONOCLONAL ANTIBODY AND USE THEREOF 55 5 AA PAT source 1..5 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD heavy chain variable region CDR1 amino acid sequence organism synthetic construct NYPIE 17 AA PAT source 1..17 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD heavy chain variable region CDR2 amino acid sequence organism synthetic construct NFHPYNDDTKYNEKFKG 11 AA PAT source 1..11 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD heavy chain variable region CDR3 amino acid sequence organism synthetic construct EDYGTYGGFAY 12 AA PAT source 1..12 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain variable region CDR1 amino acid sequence organism synthetic construct RASSSVSSSYLL 7 AA PAT source 1..7 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain variable region CDR2 amino acid sequence organism synthetic construct STSNLAS 9 AA PAT source 1..9 mol_type protein note B1-1B5-H1L1/1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain variable region CDR3 amino acid sequence organism synthetic construct QQYSGYPLT 120 AA PAT source 1..120 mol_type protein note B1-1B5-H1L1 heavy chain variable region amino acid sequence organism synthetic construct EVQLQQSGAELVKPGASVKMSCKAFGYTFTNYPIEWMKQSHGKSLEWIGNFHPYNDDTKYNEKFKGKAKLTVEKSSSTVYLELSRLTSDDSAVYYCAREDYGTYGGFAYWGQGTLVTVSS 108 AA PAT source 1..108 mol_type protein note B1-1B5-H1L1 light chain variable region amino acid sequence organism synthetic construct EITVTQSPAIMSASPGEKVTMTCRASSSVSSSYLLWYQQKSGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSVEAEDAATYYCQQYSGYPLTFGAGTKLELK 360 DNA PAT source 1..360 mol_type other DNA note B1-1B5-H1L1 heavy chain variable region nucleotide sequence organism synthetic construct gaggtccagcttcagcagtctggggctgagctggtgaagcctggggcctcagtgaagatgtcctgcaaggcttttggctacaccttcactaactatccaatagagtggatgaagcagagtcatgggaagagcctagagtggattggaaattttcatccttacaatgatgatactaaatacaatgaaaaattcaagggcaaggccaaattgactgtagaaaaatcctctagcacagtctacttggagctcagccgattaacatctgatgactctgctgtttattactgtgcaagggaggactatggtacctacggggggtttgcttactggggccaagggactctggtcaccgtctcgagc 324 DNA PAT source 1..324 mol_type other DNA note B1-1B5-H1L1 light chain variable region nucleotide sequence organism synthetic construct gaaataactgtgacccagtctccagcaatcatgtctgcatctccaggggaaaaggtcaccatgacctgcagggccagctcaagtgtaagttccagttacttgctctggtaccagcagaagtcaggtgcctcccccaaactctggatttatagcacatccaacttggcttctggagtccctgctcgcttcagtggcagtgggtctgggacctcttactctctcacaatcagcagtgtggaggctgaagatgctgccacttattactgccagcagtacagtggttacccactcacgttcggtgctgggaccaagctggagctgaaa 450 AA PAT source 1..450 mol_type protein note B1-1B5-H1L1 heavy chain amino acid sequence organism synthetic construct EVQLQQSGAELVKPGASVKMSCKAFGYTFTNYPIEWMKQSHGKSLEWIGNFHPYNDDTKYNEKFKGKAKLTVEKSSSTVYLELSRLTSDDSAVYYCAREDYGTYGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 215 AA PAT source 1..215 mol_type protein note B1-1B5-H1L1 light chain amino acid sequence organism synthetic construct EITVTQSPAIMSASPGEKVTMTCRASSSVSSSYLLWYQQKSGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSVEAEDAATYYCQQYSGYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1350 DNA PAT source 1..1350 mol_type other DNA note B1-1B5-H1L1 heavy chain nucleotide sequence organism synthetic construct gaggtccagcttcagcagtctggggctgagctggtgaagcctggggcctcagtgaagatgtcctgcaaggcttttggctacaccttcactaactatccaatagagtggatgaagcagagtcatgggaagagcctagagtggattggaaattttcatccttacaatgatgatactaaatacaatgaaaaattcaagggcaaggccaaattgactgtagaaaaatcctctagcacagtctacttggagctcagccgattaacatctgatgactctgctgtttattactgtgcaagggaggactatggtacctacggggggtttgcttactggggccaagggactctggtcaccgtctcgagcgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcctccatctcgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaa 645 DNA PAT source 1..645 mol_type other DNA note B1-1B5-H1L1 light chain nucleotide sequence organism synthetic construct gaaataactgtgacccagtctccagcaatcatgtctgcatctccaggggaaaaggtcaccatgacctgcagggccagctcaagtgtaagttccagttacttgctctggtaccagcagaagtcaggtgcctcccccaaactctggatttatagcacatccaacttggcttctggagtccctgctcgcttcagtggcagtgggtctgggacctcttactctctcacaatcagcagtgtggaggctgaagatgctgccacttattactgccagcagtacagtggttacccactcacgttcggtgctgggaccaagctggagctgaaacggaccgtggcggcgccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggtaccgctagcgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgt 120 AA PAT source 1..120 mol_type protein note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD heavy chain variable region amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKAFGYTFTNYPIEWMRQAPGQSLEWIGNFHPYNDDTKYNEKFKGRVTMTRDTSISTVYLELSRLRSDDTAVYYCAREDYGTYGGFAYWGQGTLVTVSS 108 AA PAT source 1..108 mol_type protein note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain variable region amino acid sequence organism synthetic construct EIVLTQSPATLSLSPGERATLTCRASSSVSSSYLLWYQQKSGAAPRLWIYSTSNLASGVPARFSGSGSGTDFTLTISSLEPEDFATYYCQQYSGYPLTFGQGTKLEIK 360 DNA PAT source 1..360 mol_type other DNA note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD heavy chain variable region nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggctttcggctacacctttaccaactatcccatcgagtggatgcggcaggctcctggccaaagcctggaatggatcggcaactttcacccctacaacgacgacaccaagtacaacgagaagttcaagggccgcgtgaccatgaccagagacacctccatctccaccgtgtacctggaactgtcccggctgagatctgacgacaccgccgtgtactactgcgccagagaggattacggcacctacggcggctttgcttattggggccagggcacactggtcacagtgtcctct 324 DNA PAT source 1..324 mol_type other DNA note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain variable region nucleotide sequence organism synthetic construct gagatcgtgctgacccagtctcctgccacactgtcactgtctccaggcgagagagctaccctgacctgcagagcctcttccagcgtgtcctcctcttacctgctgtggtatcagcagaagtccggcgctgctcccagactgtggatctactccacctccaatctggcctctggcgtgccagccagattttccggttctggctctggcaccgactttaccctgacaatctccagcctggaacctgaggacttcgccacctactactgccagcagtacagcggctaccctctgacctttggccagggcaccaagctggaaatcaag 450 AA PAT source 1..450 mol_type protein note 1B5-zu1-hIgG1 heavy chain amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKAFGYTFTNYPIEWMRQAPGQSLEWIGNFHPYNDDTKYNEKFKGRVTMTRDTSISTVYLELSRLRSDDTAVYYCAREDYGTYGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 215 AA PAT source 1..215 mol_type protein note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain amino acid sequence organism synthetic construct EIVLTQSPATLSLSPGERATLTCRASSSVSSSYLLWYQQKSGAAPRLWIYSTSNLASGVPARFSGSGSGTDFTLTISSLEPEDFATYYCQQYSGYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1350 DNA PAT source 1..1350 mol_type other DNA note 1B5-zu1-hIgG1 heavy chain nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggctttcggctacacctttaccaactatcccatcgagtggatgcggcaggctcctggccaaagcctggaatggatcggcaactttcacccctacaacgacgacaccaagtacaacgagaagttcaagggccgcgtgaccatgaccagagacacctccatctccaccgtgtacctggaactgtcccggctgagatctgacgacaccgccgtgtactactgcgccagagaggattacggcacctacggcggctttgcttattggggccagggcacactggtcacagtgtcctctgcttccaccaagggcccctccgtgttccccctggctccctcttccaagagcaccagcggcggcaccgctgctctgggatgtctggtgaaggactacttccctgagcctgtgaccgtgtcctggaattccggcgccctgacctccggcgtgcacacattccctgctgtgctgcagtcctccggcctgtatagcctgtcctccgtggtgacagtgcctagctccagcctgggcacccagacctatatctgcaacgtgaaccacaagcctagcaataccaaggtggacaagaaggtggagcctaagagctgcgacaagacccacacctgtcctccatgtcctgctccagaactgctcggcggaccttccgtgttcctgtttcctccaaagcctaaggacaccctgatgatcagcagaacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaacagcacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgctcctatcgagaaaaccatcagcaaggccaagggccagcctagggaaccccaggtttacacactgcctccaagcagggacgagctgaccaagaatcaggtgtccctgacctgcctggtcaagggcttctacccttccgatatcgccgtggaatgggagagcaatggccagcctgagaacaactacaagacaacccctcctgtgctggacagcgacggctcattcttcctgtacagcaagctgacagtggacaagagcagatggcagcagggcaacgtgttcagctgcagcgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctgtctcctggcaaa 645 DNA PAT source 1..645 mol_type other DNA note 1B5-zu1-hIgG1/1B5-zu1-hIgG1 DD light chain nucleotide sequence organism synthetic construct gagatcgtgctgacccagtctcctgccacactgtcactgtctccaggcgagagagctaccctgacctgcagagcctcttccagcgtgtcctcctcttacctgctgtggtatcagcagaagtccggcgctgctcccagactgtggatctactccacctccaatctggcctctggcgtgccagccagattttccggttctggctctggcaccgactttaccctgacaatctccagcctggaacctgaggacttcgccacctactactgccagcagtacagcggctaccctctgacctttggccagggcaccaagctggaaatcaagaggaccgtggctgcccccagcgtgttcatcttccctcctagcgacgagcagctgaagagcggcaccgctagcgtggtgtgtctgctgaataacttctatcccagggaggccaaggtgcagtggaaggtggataacgccctgcagagcggcaactcccaggagtccgtgaccgagcaggactccaaggacagcacctactccctgagctccaccctgaccctgtccaaggctgattatgagaagcacaaggtgtatgcttgcgaggtgacacaccagggcctgtccagccctgtgaccaagagcttcaaccggggcgagtgc 450 AA PAT source 1..450 mol_type protein note 1B5-zu1-hIgG1 DD heavy chain amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKAFGYTFTNYPIEWMRQAPGQSLEWIGNFHPYNDDTKYNEKFKGRVTMTRDTSISTVYLELSRLRSDDTAVYYCAREDYGTYGGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSDEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 1350 DNA PAT source 1..1350 mol_type other DNA note 1B5-zu1-hIgG1 DD heavy chain nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggctttcggctacacctttaccaactatcccatcgagtggatgcggcaggctcctggccaaagcctggaatggatcggcaactttcacccctacaacgacgacaccaagtacaacgagaagttcaagggccgcgtgaccatgaccagagacacctccatctccaccgtgtacctggaactgtcccggctgagatctgacgacaccgccgtgtactactgcgccagagaggattacggcacctacggcggctttgcttattggggccagggcacactggtcacagtgtcctctgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccggacgtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagcgacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcctccatctcgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaa 5 AA PAT source 1..5 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD heavy chain variable region CDR1 amino acid sequence organism synthetic construct SYWIT 17 AA PAT source 1..17 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD heavy chain variable region CDR2 amino acid sequence organism synthetic construct RIAPGSGSIYYDEMFKD 10 AA PAT source 1..10 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD heavy chain variable region CDR3 amino acid sequence organism synthetic construct LGNYGWTMDY 11 AA PAT source 1..11 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain variable region CDR1 amino acid sequence organism synthetic construct KASQSVTNNVA 7 AA PAT source 1..7 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain variable region CDR2 amino acid sequence organism synthetic construct YVSNRYT 8 AA PAT source 1..8 mol_type protein note B1-1C4-H1L1/1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain variable region CDR3 amino acid sequence organism synthetic construct QQDYSSWT 119 AA PAT source 1..119 mol_type protein note B1-1C4-H1L1 heavy chain variable region amino acid sequence organism synthetic construct EVQLQQSGDDLVKPGASVKLSCKASGYTFTSYWITWIKQRPGQGLEWIGRIAPGSGSIYYDEMFKDKATLTVDPSSSTAYIQLSSLSSEDSAVYFCARLGNYGWTMDYWGQGTSVTVSS 106 AA PAT source 1..106 mol_type protein note B1-1C4-H1L1 light chain variable region amino acid sequence organism synthetic construct DIVMTQTPKFLLVSAGDRVTITCKASQSVTNNVAWYQQAPGQSPKLLIYYVSNRYTGVPDRFAGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSWTFGGGTKLEIK 357 DNA PAT source 1..357 mol_type other DNA note B1-1C4-H1L1 heavy chain variable region nucleotide sequence organism synthetic construct gaggtccagcttcagcagtctggagatgatctggtaaagcctggggcctcagtgaagctgtcctgcaaggcttctggctacaccttcaccagctactggattacctggataaaacagaggcctggacagggccttgagtggataggacgtattgctcctggaagtggtagtatttactacgatgaaatgttcaaggacaaggcaacactgactgtagacccatcctccagcacagcctacattcaactcagcagcctgtcatctgaggactctgctgtctatttctgtgcaagattgggtaactacggatggactatggactactggggtcaaggaacctcagtcaccgtctcgagc 318 DNA PAT source 1..318 mol_type other DNA note B1-1C4-H1L1 light chain variable region nucleotide sequence organism synthetic construct gatattgtgatgacccagactcccaaattcctgcttgtatcagcaggagacagggttaccataacctgcaaggccagtcagagtgtgactaataatgtagcttggtatcaacaggcgccaggtcagtctcctaaactgctgatatattatgtatccaatcgctacactggagtccctgatcgcttcgctggcagtggatatgggacggatttcactttcaccatcagcactgtgcaggctgaagacctggcagtttatttctgtcaacaggattatagctcttggacgttcggtgggggcaccaagctggaaatcaaa 449 AA PAT source 1..449 mol_type protein note B1-1C4-H1L1 heavy chain amino acid sequence organism synthetic construct EVQLQQSGDDLVKPGASVKLSCKASGYTFTSYWITWIKQRPGQGLEWIGRIAPGSGSIYYDEMFKDKATLTVDPSSSTAYIQLSSLSSEDSAVYFCARLGNYGWTMDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 213 AA PAT source 1..213 mol_type protein note B1-1C4-H1L1 light chain amino acid sequence organism synthetic construct DIVMTQTPKFLLVSAGDRVTITCKASQSVTNNVAWYQQAPGQSPKLLIYYVSNRYTGVPDRFAGSGYGTDFTFTISTVQAEDLAVYFCQQDYSSWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1347 DNA PAT source 1..1347 mol_type other DNA note B1-1C4-H1L1 heavy chain nucleotide sequence organism synthetic construct gaggtccagcttcagcagtctggagatgatctggtaaagcctggggcctcagtgaagctgtcctgcaaggcttctggctacaccttcaccagctactggattacctggataaaacagaggcctggacagggccttgagtggataggacgtattgctcctggaagtggtagtatttactacgatgaaatgttcaaggacaaggcaacactgactgtagacccatcctccagcacagcctacattcaactcagcagcctgtcatctgaggactctgctgtctatttctgtgcaagattgggtaactacggatggactatggactactggggtcaaggaacctcagtcaccgtctcgagcgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcctccatctcgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaa 639 DNA PAT source 1..639 mol_type other DNA note B1-1C4-H1L1 light chain nucleotide sequence organism synthetic construct gatattgtgatgacccagactcccaaattcctgcttgtatcagcaggagacagggttaccataacctgcaaggccagtcagagtgtgactaataatgtagcttggtatcaacaggcgccaggtcagtctcctaaactgctgatatattatgtatccaatcgctacactggagtccctgatcgcttcgctggcagtggatatgggacggatttcactttcaccatcagcactgtgcaggctgaagacctggcagtttatttctgtcaacaggattatagctcttggacgttcggtgggggcaccaagctggaaatcaaacggaccgtggcggcgccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggtaccgctagcgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgt 119 AA PAT source 1..119 mol_type protein note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD heavy chain variable region amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWITWIRQAPGQGLEWIGRIAPGSGSIYYDEMFKDRVTMTVDPSTSTAYIELSSLRSEDTAVYYCARLGNYGWTMDYWGQGTTVTVSS 106 AA PAT source 1..106 mol_type protein note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain variable region amino acid sequence organism synthetic construct DIVMTQSPKSLAVSLGERATINCKASQSVTNNVAWYQQKPGQPPKLLIYYVSNRYTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYFCQQDYSSWTFGGGTKVEIK 357 DNA PAT source 1..357 mol_type other DNA note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD heavy chain variable region nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggcttccggctacacctttaccagctactggatcacctggatcagacaggctcccggccaaggcctggaatggatcggaagaatcgctcctggctccggctccatctactacgacgagatgttcaaggaccgcgtgaccatgacagtggacccttctacctccaccgcctacatcgagctgtccagcctgagatctgaggacaccgccgtgtactactgtgccagactgggcaactacggctggacaatggattactggggccagggcaccaccgtgacagtctcttct 318 DNA PAT source 1..318 mol_type other DNA note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain variable region nucleotide sequence organism synthetic construct gacatcgtgatgacccagtctccaaagtctctggccgtgtctctgggcgagagagccaccatcaattgcaaggcctctcagtccgtgaccaacaacgtggcctggtatcagcagaagcctggccagcctcctaagctgctgatctactacgtgtccaaccggtacaccggcgtgcccgatagattttccggctctggctacggcaccgactttaccctgacaatcagctccctgcaggccgaggatgtggccgtgtacttctgccagcaagactactcctcctggacctttggcggaggcaccaaggtggaaatcaag 449 AA PAT source 1..449 mol_type protein note 1C4-zu1-hIgG1 heavy chain amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWITWIRQAPGQGLEWIGRIAPGSGSIYYDEMFKDRVTMTVDPSTSTAYIELSSLRSEDTAVYYCARLGNYGWTMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 213 AA PAT source 1..213 mol_type protein note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain amino acid sequence organism synthetic construct DIVMTQSPKSLAVSLGERATINCKASQSVTNNVAWYQQKPGQPPKLLIYYVSNRYTGVPDRFSGSGYGTDFTLTISSLQAEDVAVYFCQQDYSSWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 1347 DNA PAT source 1..1347 mol_type other DNA note 1C4-zu1-hIgG1 heavy chain nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggcttccggctacacctttaccagctactggatcacctggatcagacaggctcccggccaaggcctggaatggatcggaagaatcgctcctggctccggctccatctactacgacgagatgttcaaggaccgcgtgaccatgacagtggacccttctacctccaccgcctacatcgagctgtccagcctgagatctgaggacaccgccgtgtactactgtgccagactgggcaactacggctggacaatggattactggggccagggcaccaccgtgacagtctcttctgcttccaccaagggcccctccgtgttccccctggctccctcttccaagagcaccagcggcggcaccgctgctctgggatgtctggtgaaggactacttccctgagcctgtgaccgtgtcctggaattccggcgccctgacctccggcgtgcacacattccctgctgtgctgcagtcctccggcctgtatagcctgtcctccgtggtgacagtgcctagctccagcctgggcacccagacctatatctgcaacgtgaaccacaagcctagcaataccaaggtggacaagaaggtggagcctaagagctgcgacaagacccacacctgtcctccatgtcctgctccagaactgctcggcggaccttccgtgttcctgtttcctccaaagcctaaggacaccctgatgatcagcagaacccctgaagtgacctgcgtggtggtggatgtgtcccacgaggatcccgaagtgaagttcaattggtacgtggacggcgtggaagtgcacaacgccaagaccaagcctagagaggaacagtacaacagcacctacagagtggtgtccgtgctgaccgtgctgcaccaggattggctgaacggcaaagagtacaagtgcaaggtgtccaacaaggccctgcctgctcctatcgagaaaaccatcagcaaggccaagggccagcctagggaaccccaggtttacacactgcctccaagcagggacgagctgaccaagaatcaggtgtccctgacctgcctggtcaagggcttctacccttccgatatcgccgtggaatgggagagcaatggccagcctgagaacaactacaagacaacccctcctgtgctggacagcgacggctcattcttcctgtacagcaagctgacagtggacaagagcagatggcagcagggcaacgtgttcagctgcagcgtgatgcacgaggccctgcacaaccactacacccagaagtccctgagcctgtctcctggcaaa 639 DNA PAT source 1..639 mol_type other DNA note 1C4-zu1-hIgG1/1C4-zu1-hIgG1 DD light chain nucleotide sequence organism synthetic construct gacatcgtgatgacccagtctccaaagtctctggccgtgtctctgggcgagagagccaccatcaattgcaaggcctctcagtccgtgaccaacaacgtggcctggtatcagcagaagcctggccagcctcctaagctgctgatctactacgtgtccaaccggtacaccggcgtgcccgatagattttccggctctggctacggcaccgactttaccctgacaatcagctccctgcaggccgaggatgtggccgtgtacttctgccagcaagactactcctcctggacctttggcggaggcaccaaggtggaaatcaagaggaccgtggctgcccccagcgtgttcatcttccctcctagcgacgagcagctgaagagcggcaccgctagcgtggtgtgtctgctgaataacttctatcccagggaggccaaggtgcagtggaaggtggataacgccctgcagagcggcaactcccaggagtccgtgaccgagcaggactccaaggacagcacctactccctgagctccaccctgaccctgtccaaggctgattatgagaagcacaaggtgtatgcttgcgaggtgacacaccagggcctgtccagccctgtgaccaagagcttcaaccggggcgagtgc 449 AA PAT source 1..449 mol_type protein note 1C4-zu1-hIgG1 DD heavy chain amino acid sequence organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWITWIRQAPGQGLEWIGRIAPGSGSIYYDEMFKDRVTMTVDPSTSTAYIELSSLRSEDTAVYYCARLGNYGWTMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSDEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 1347 DNA PAT source 1..1347 mol_type other DNA note 1C4-zu1-hIgG1 DD heavy chain nucleotide sequence organism synthetic construct caggttcagctggttcagtctggcgccgaagtgaagaaacctggcgcctctgtgaaggtgtcctgcaaggcttccggctacacctttaccagctactggatcacctggatcagacaggctcccggccaaggcctggaatggatcggaagaatcgctcctggctccggctccatctactacgacgagatgttcaaggaccgcgtgaccatgacagtggacccttctacctccaccgcctacatcgagctgtccagcctgagatctgaggacaccgccgtgtactactgtgccagactgggcaactacggctggacaatggattactggggccagggcaccaccgtgacagtctcttctgctagcaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccggacgtcttcctcttccccccaaaacccaaggacaccctcatgatctcccggacccctgaggtcacatgcgtggtggtggacgtgagcgacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtctccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcctccatctcgggatgagctgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctatagcaagctcaccgtggacaagagcaggtggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagagcctctccctgtctccgggtaaa 288 AA PAT source 1..288 mol_type protein note Full-length hPD-1 amino acid sequence organism synthetic construct MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL 147 AA PAT source 1..147 mol_type protein note hPD-1 ECD amino acid sequence organism synthetic construct FLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLV 330 AA PAT source 1..330 mol_type protein note hIgG1 heavy chain constant region amino acid sequence organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT source 1..330 mol_type protein note hIgG1(DD) heavy chain constant region amino acid sequence organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSDEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note Human kappa light chain constant region sequence organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 288 AA PAT source 1..288 mol_type protein note cPD-1 amino acid sequence organism synthetic construct MQIPQAPWPVVWAVLQLGWRPGWFLESPDRPWNAPTFSPALLLVTEGDNATFTCSFSNASESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTRLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQALVVGVVGGLLGSLVLLVWVLAVICSRAAQGTIEARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPAPCVPEQTEYATIVFPSGLGTSSPARRGSADGPRSPRPLRPEDGHCSWPL 147 AA PAT source 1..147 mol_type protein note cPD-1 ECD amino acid sequence organism synthetic construct FLESPDRPWNAPTFSPALLLVTEGDNATFTCSFSNASESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTRLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQALV