WO 3338.293PC01 US 63/314,137 2022-02-25 BRISTOL-MYERS SQUIBB COMPANY Rebecca Anne Moss COMBINATION THERAPY FOR COLORECTAL CARCINOMA 86 447 AA PAT source 1..447 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein note Light Chain Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT source 1..120 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct DYYWN 16 AA PAT source 1..16 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct EINHRGSTNSNPSLKS 12 AA PAT source 1..12 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct GYSDYEYNWFDP 11 AA PAT source 1..11 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct RASQSISSYLA 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct DASNRAT 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct QQRSNWPLT 440 AA PAT source 1..440 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 213 AA PAT source 1..213 mol_type protein note Light Chain Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 113 AA PAT source 1..113 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-PD-1 (BMS-936558) organism synthetic construct QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct NSGMH 17 AA PAT source 1..17 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct VIWYDGSKRYYADSVKG 4 AA PAT source 1..4 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct NDDY 11 AA PAT source 1..11 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct DASNRAT 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (BMS-936558) organism synthetic construct QQSSNWPRT 446 AA PAT source 1..446 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (BMS-986016) organism synthetic construct QVQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 525 AA PAT source 1..525 mol_type protein note Lymphocyte Activation Gene 3 Protein Amino Acid Sequence organism synthetic construct MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLILGVLSLLLLVTGAFGFHLWRRQWRPRRFSALEQGIHPPQAQSKIEELEQEPEPEPEPEPEPEPEPEPEQL 449 AA PAT source 1..449 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct QVQLVESGGGVVQPGRSLRLSCVASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTQYLQMNSLRAEDTAVYYCASVATSGDFDYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein note Light Chain Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct EIVLTQSPATLSLSPGERTTLSCRASQRISTYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTGFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 123 AA PAT source 1..123 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct QVQLVESGGGVVQPGRSLRLSCVASGFTFSSYGMHWVRQAPGKGLEWVAIIWYDGSNKYYADSVKGRFTISRDNSKNTQYLQMNSLRAEDTAVYYCASVATSGDFDYYGMDVWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct EIVLTQSPATLSLSPGERTTLSCRASQRISTYLAWYQQKPGQAPRLLIYDASKRATGIPARFSGSGSGTGFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK 8 AA PAT source 1..8 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct GFTFSSYG 8 AA PAT source 1..8 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct IWYDGSNK 16 AA PAT source 1..16 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct ASVATSGDFDYYGMDV 6 AA PAT source 1..6 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct QRISTY 000 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (REGN3767) organism synthetic construct QQRSNWPLT 444 AA PAT source 1..444 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct EVQLLESGGVLVQPGGSLRLSCAASGFTFSNFGMTWVRQAPGKGLEWVSGISGGGRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNIYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein note Light Chain Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct DIQMTQSPSSLSASVGDSITITCRASLSINTFLNWYQQKPGKAPNLLIYAASSLHGGVPSRFSGSGSGTDFTLTIRTLQPEDFATYYCQQSSNTPFTFGPGTVVDFRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 117 AA PAT source 1..117 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct EVQLLESGGVLVQPGGSLRLSCAASGFTFSNFGMTWVRQAPGKGLEWVSGISGGGRDTYFADSVKGRFTISRDNSKNTLYLQMNSLKGEDTAVYYCVKWGNIYFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct DIQMTQSPSSLSASVGDSITITCRASLSINTFLNWYQQKPGKAPNLLIYAASSLHGGVPSRFSGSGSGTDFTLTIRTLQPEDFATYYCQQSSNTPFTFGPGTVVDFR 8 AA PAT source 1..8 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct GFTFSNFG 8 AA PAT source 1..8 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct ISGGGRDT 10 AA PAT source 1..10 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct VKWGNIYFDY 6 AA PAT source 1..6 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct LSINTF 000 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (REGN2810) organism synthetic construct QQSSNTPFT 451 AA PAT source 1..451 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQARGQRLEWIGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 451 AA PAT source 1..451 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQAPGQGLEWMGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 214 AA PAT source 1..214 mol_type protein note Light Chain Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYLQKPGQSPQLLIYYTSTLHLGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYYNLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Light Chain Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYQQKPGKAPKLLIYYTSTLHLGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQQYYNLPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 125 AA PAT source 1..125 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQARGQRLEWIGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSS 125 AA PAT source 1..125 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGFTLTNYGMNWVRQAPGQGLEWMGWINTDTGEPTYADDFKGRFVFSLDTSVSTAYLQISSLKAEDTAVYYCARNPPYYYGTNNAEAMDYWGQGTTVTVSS 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYLQKPGQSPQLLIYYTSTLHLGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQYYNLPWTFGQGTKVEIK 107 AA PAT source 1..107 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct DIQMTQSPSSLSASVGDRVTITCSSSQDISNYLNWYQQKPGKAPKLLIYYTSTLHLGIPPRFSGSGYGTDFTLTINNIESEDAAYYFCQQYYNLPWTFGQGTKVEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct NYGMN 17 AA PAT source 1..17 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct WINTDTGEPTYADDFKG 16 AA PAT source 1..16 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct NPPYYYGTNNAEAMDY 11 AA PAT source 1..11 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct SSSQDISNYLN 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct YTSTLHL 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (LAG525) organism synthetic construct QQYYNLPWT 443 AA PAT source 1..443 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYTFTTYWMHWVRQATGQGLEWMGNIYPGTGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTGTGAYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 220 AA PAT source 1..220 mol_type protein note Light Chain Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct EIVLTQSPATLSLSPGERATLSCKSSQSLLDSGNQKNFLTWYQQKPGQAPRLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQNDYSYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 117 AA PAT source 1..117 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYTFTTYWMHWVRQATGQGLEWMGNIYPGTGGSNFDEKFKNRVTITADKSTSTAYMELSSLRSEDTAVYYCTRWTTGTGAYWGQGTTVTVSS 113 AA PAT source 1..113 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct EIVLTQSPATLSLSPGERATLSCKSSQSLLDSGNQKNFLTWYQQKPGQAPRLLIYWASTRESGVPSRFSGSGSGTDFTFTISSLEAEDAATYYCQNDYSYPYTFGQGTKVEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct TYWMH 17 AA PAT source 1..17 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct NIYPGTGGSNFDEKFKN 8 AA PAT source 1..8 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct WTTGTGAY 17 AA PAT source 1..17 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct KSSQSLLDSGNQKNFLT 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct WASTRES 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (PDR001) organism synthetic construct QNDYSYPYT 446 AA PAT source 1..446 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct QMQLVQSGPEVKKPGTSVKVSCKASGYTFTDYNVDWVRQARGQRLEWIGDINPNDGGTIYAQKFQERVTITVDKSTSTAYMELSSLRSEDTAVYYCARNYRWFGAMDHWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 218 AA PAT source 1..218 mol_type protein note Light Chain Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct DIVMTQTPLSLSVTPGQPASISCKASQSLDYEGDSDMNWYLQKPGQPPQLLIYGASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSTEDPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 119 AA PAT source 1..119 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct QMQLVQSGPEVKKPGTSVKVSCKASGYTFTDYNVDWVRQARGQRLEWIGDINPNDGGTIYAQKFQERVTITVDKSTSTAYMELSSLRSEDTAVYYCARNYRWFGAMDHWGQGTTVTVSS 111 AA PAT source 1..111 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-LAG-3 Anti-LAG-3 mAb (MK4280) organism synthetic construct DIVMTQTPLSLSVTPGQPASISCKASQSLDYEGDSDMNWYLQKPGQPPQLLIYGASNLESGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCQQSTEDPRTFGGGTKVEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct DYNVD 17 AA PAT source 1..17 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct DINPNDGGTIYAQKFQE 10 AA PAT source 1..10 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct NYRWFGAMDH 15 AA PAT source 1..15 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct KASQSLDYEGDSDMN 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct GASNLES 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-LAG-3 mAb (MK4280) organism synthetic construct QQSTEDPRT 447 AA PAT source 1..447 mol_type protein note Heavy Chain Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 218 AA PAT source 1..218 mol_type protein note Light Chain Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT source 1..120 mol_type protein note Heavy Chain Variable Region (VH) Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSS 111 AA PAT source 1..111 mol_type protein note Light Chain Variable Region (VL) Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIK 5 AA PAT source 1..5 mol_type protein note Heavy Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct NYYMY 17 AA PAT source 1..17 mol_type protein note Heavy Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (MK4280) organism synthetic construct GINPSNGGTNFNEKFKN 11 AA PAT source 1..11 mol_type protein note Heavy Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct RDYRFDMGFDY 15 AA PAT source 1..15 mol_type protein note Light Chain CDR1 Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct RASKGVSTSGYSYLH 7 AA PAT source 1..7 mol_type protein note Light Chain CDR2 Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct LASYLES 9 AA PAT source 1..9 mol_type protein note Light Chain CDR3 Amino Acid Sequence; Anti-PD-1 mAb (MK3475) organism synthetic construct QHSRDLPLT