230008WO01 EP 22159644.8 2022-03-02 Novo Nordisk A/S Mads KreilGaard NOVEL METHODS OF ADMINISTERING FVIII MIMETICS 22 415 AA PAT source 1..415 mol_type protein organism Homo sapiens YNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAEAVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 448 AA PAT source 1..448 mol_type protein organism Homo sapiens ANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 5 AA PAT REGION 1..5 note HCDR1 source 1..5 mol_type protein organism synthetic construct DYAMH 17 AA PAT REGION 1..17 note HCDR2 source 1..17 mol_type protein organism synthetic construct GISWRGDIGGYVKSVKG 13 AA PAT REGION 1..13 note HCDR3 source 1..13 mol_type protein organism synthetic construct SYGSGSFYNAFDS 122 AA PAT REGION 1..122 note Artificial source 1..122 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFHDYAMHWVRQVPGKGLEWVSGISWRGDIGGYVKSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVKSYGSGSFYNAFDSWGQGTLVTVSS 448 AA PAT REGION 1..448 note Artificial, anti-FIX heavy chain source 1..448 mol_type protein organism synthetic construct EVQLVESGGGLVQPGRSLRLSCAASGFTFHDYAMHWVRQVPGKGLEWVSGISWRGDIGGYVKSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVKSYGSGSFYNAFDSWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 11 AA PAT REGION 1..11 note LCDR1 source 1..11 mol_type protein organism synthetic construct RASQSISSWLA 7 AA PAT REGION 1..7 note LCDR2 source 1..7 mol_type protein organism synthetic construct KASKLER 9 AA PAT REGION 1..9 note LCDR3 source 1..9 mol_type protein organism synthetic construct LEYSSYIRT 107 AA PAT REGION 1..107 note anti-FIX(a) VL source 1..107 mol_type protein organism synthetic construct DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKFLIYKASKLERGTPSRFSGSGSGTEFSLTISSLQPDDFATYYCLEYSSYIRTFGQGTKVEIK 214 AA PAT REGION 1..214 note anti-FIX light chain source 1..214 mol_type protein organism synthetic construct DIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKFLIYKASKLERGTPSRFSGSGSGTEFSLTISSLQPDDFATYYCLEYSSYIRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 5 AA PAT REGION 1..5 note anti-FX(a) HCDR1 source 1..5 mol_type protein organism synthetic construct TSWIV 17 AA PAT REGION 1..17 note anti-FX(a) HCDR2 source 1..17 mol_type protein organism synthetic construct MIDPSDSFTSYSPSFQG 11 AA PAT REGION 1..11 note anti-FX(a) HCDR3 source 1..11 mol_type protein organism synthetic construct LHYYNSEEFDV 120 AA PAT REGION 1..120 note anti-FX(a) VH source 1..120 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYSFSTSWIVWVRQMPGKGLEWMGMIDPSDSFTSYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCARLHYYNSEEFDVWGQGTLVTVSS 446 AA PAT REGION 1..446 note Artificial, anti-FX heavy chain source 1..446 mol_type protein organism synthetic construct EVQLVQSGAEVKKPGESLRISCKGSGYSFSTSWIVWVRQMPGKGLEWMGMIDPSDSFTSYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCARLHYYNSEEFDVWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 12 AA PAT REGION 1..12 note anti-FX(a) LCDR1 source 1..12 mol_type protein organism synthetic construct RASQSVSSSYLA 7 AA PAT REGION 1..7 note anti-FX(a) LCDR2 source 1..7 mol_type protein organism synthetic construct GQSSRTR 10 AA PAT REGION 1..10 note anti-FX(a) LCDR3 source 1..10 mol_type protein organism synthetic construct QQFGDSQLFT 109 AA PAT REGION 1..109 note anti-FX(a) VL source 1..109 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGQSSRTRGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFGDSQLFTFGQGTKLEIK 216 AA PAT REGION 1..216 note Artificial, anti-FX light chain source 1..216 mol_type protein organism synthetic construct EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGQSSRTRGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQFGDSQLFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC