AU 53225888AZD AU 2021903279 2021-10-12 Monash University Modified binding proteins and therapeutic uses thereof 226 10 AA PAT source 1..10 mol_type protein organism Synthetic construct LIKCDERGKM 10 AA PAT source 1..10 mol_type protein organism Synthetic construct GCLFDRRLCS 10 AA PAT source 1..10 mol_type protein organism Synthetic construct EYKIADPICT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct EFRNMVTRCN 10 AA PAT source 1..10 mol_type protein organism Synthetic construct CLLLLSSRPG 10 AA PAT source 1..10 mol_type protein organism Synthetic construct EWQALCAYQA 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AYQAEPNTCA 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ELRKFSSLCY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct PVLLLESHCA 10 AA PAT source 1..10 mol_type protein organism Synthetic construct IICYNWLHRR 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RFRCQPGFVM 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RLMMLQSCSG 10 AA PAT source 1..10 mol_type protein organism Synthetic construct CVRTMSALWN 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ILRSMCGYQT 9 AA PAT source 1..9 mol_type protein organism Homo sapiens EGDCAPEEK 9 AA PAT source 1..9 mol_type protein organism Homo sapiens NYKRCFPVI 9 AA PAT source 1..9 mol_type protein organism Homo sapiens MLAVISCAV 10 AA PAT source 1..10 mol_type protein organism Homo sapiens EYSKECLKEF 9 AA PAT source 1..9 mol_type protein organism Homo sapiens RLSSCVPVA 9 AA PAT source 1..9 mol_type protein organism Homo sapiens FLDRFLSCM 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AVNFGGGKLI 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ALFLASSSFSKLV 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AMRGDSSYKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct LVGEILDNFNK 8 AA PAT source 1..8 mol_type protein organism Synthetic construct LVVDQKLV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct IVWGGYQKVT 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ILPLAGGTSYGKLT 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AVNVAGKST 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AVNVAGKST 12 AA PAT source 1..12 mol_type protein organism Synthetic construct AVQASGGSYIPT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AVRPGGAGPFFVV 12 AA PAT source 1..12 mol_type protein organism Synthetic construct GTERSGGYQKVT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AMREDTGNFY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ILPLAGGTSYGKLT 8 AA PAT source 1..8 mol_type protein organism Synthetic construct VVRAGKLI 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AASFIIQGAQKLV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AFDTNAGKST 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AGAGSQGNLI 15 AA PAT source 1..15 mol_type protein organism Synthetic construct AWGVNAGGTSYGKLT 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AEDNNARLM 10 AA PAT source 1..10 mol_type protein organism Synthetic construct GLGDAGNMLT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AVQDLGTSGSRLT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ALSDPVNDMR 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AVDSATSGTYKYI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ALGEGGAQKLV 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ALSHNSGGSNYKLT 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AYGEDDKII 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AMRDLRDNFNKFY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AGGTGNQFY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AVTTDSWGKLQ 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ALSGFYNTDKLI 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AVNFGGGKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AMRGDSSYKLI 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AFITGNQFY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ILDNNNDMR 14 AA PAT source 1..14 mol_type protein organism Synthetic construct AVGAPSGAGSYQLT 11 AA PAT source 1..11 mol_type protein organism Synthetic construct WGTYNQGGKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AMRGDSSYKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AVKSGGSYIPT 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AVRTNSGYALN 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AVNFGGGKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ATDDDSARQLT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AGQPLGGSNYKLT 12 AA PAT source 1..12 mol_type protein organism Synthetic construct IVVRSSNTGKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSLSFGTEAF 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSDWVSYEQY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASSLWEKLAKNIQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSQRQEGDTQY 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSGGHTGSNEQF 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASRYRDDSYNEQF 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSLGQAYEQY 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AWSETGLGTGELF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ATGTGDSNQPQH 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSFNMATGQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSMSAMGTEAF 16 AA PAT source 1..16 mol_type protein organism Synthetic construct ASSFTWTSGGATDTQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSLGQAYEQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASGQGNFDIQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSLLGGWSEAF 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSIFGQREQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSSRSSYEQY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSIGVYGYT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSIGVYGYT 11 AA PAT source 1..11 mol_type protein organism Synthetic construct SARDGTGNGYT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSLGQGLLYGYT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSARSGELF 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSARSGELF 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSLRGRGDQPQH 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSYQGTEAF 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSFRGGKTQY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASRRGPYEQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASREGLGGTEAF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct AISEVGVGQPQH 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASRPGLAGGRPEQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASPGLAGEYEQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSRTGSTYEQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSQTQLWETQY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASSLAPGTTNEKLF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSPTSGIYEQY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSGASHEQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSSWDTGELF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSYLNRDSALD 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSDTVSYEQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASSLSFGTEAF 15 AA PAT source 1..15 mol_type protein organism Synthetic construct ASSANPGDSSNEKLF 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ASSQDRDTQY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct AAGIGILTV 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ALWGFFPVL 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ALWGPDPAAA 13 AA PAT source 1..13 mol_type protein organism Synthetic construct APRGPHGGAASGL 10 AA PAT source 1..10 mol_type protein organism Synthetic construct EENLLDFVRF 9 AA PAT source 1..9 mol_type protein organism Synthetic construct EEYLQAFTY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ELAGIGILTV 11 AA PAT source 1..11 mol_type protein organism Synthetic construct EPLPQGQLTAY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ESDPIVAQY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct EVDPIGHLY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct FEDLRVLSF 9 AA PAT source 1..9 mol_type protein organism Synthetic construct FLRGRAYGL 9 AA PAT source 1..9 mol_type protein organism Synthetic construct GILGFVFTL 9 AA PAT source 1..9 mol_type protein organism Synthetic construct GLCTLVAML 10 AA PAT source 1..10 mol_type protein organism Synthetic construct GTSGSPIVNR 11 AA PAT source 1..11 mol_type protein organism Synthetic construct HPVGEADYFEY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct HSKKKCDEL 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ILAKFLHWL 9 AA PAT source 1..9 mol_type protein organism Synthetic construct IPLTEEAEL 10 AA PAT source 1..10 mol_type protein organism Synthetic construct KLVALGINAV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct KRWIILGLNK 9 AA PAT source 1..9 mol_type protein organism Synthetic construct LAGIGILTV 9 AA PAT source 1..9 mol_type protein organism Synthetic construct LLFGYPVYV 13 AA PAT source 1..13 mol_type protein organism Synthetic construct LPEPLPQGQLTAY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct MMWDRGLGMM 10 AA PAT source 1..10 mol_type protein organism Synthetic construct MVWGPDPLYV 9 AA PAT source 1..9 mol_type protein organism Synthetic construct NLVPMVATV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RFPLTFGWCF 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RQFGPDFPTI 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RQFGPDWIVA 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RQWGPDPAAV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct RYPLTFGWCF 9 AA PAT source 1..9 mol_type protein organism Synthetic construct SLLMWITQV 9 AA PAT source 1..9 mol_type protein organism Synthetic construct SLYNTVATL 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SMLGIGIVPV 8 AA PAT source 1..8 mol_type protein organism Synthetic construct TAFTIPSI 9 AA PAT source 1..9 mol_type protein organism Synthetic construct VMAPRTLIL 10 AA PAT source 1..10 mol_type protein organism Synthetic construct IAFQGAQKLV 16 AA PAT source 1..16 mol_type protein organism Synthetic construct LVGDGGSFSGGYNKLI 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ILRDGRGGADGLT 12 AA PAT source 1..12 mol_type protein organism Synthetic construct AVDRGSTLGRLY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AALIQGAQKLV 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AVSESPFGNEKLT 12 AA PAT source 1..12 mol_type protein organism Synthetic construct AVGASGNTGKLI 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ALSGGDSSYKLI 11 AA PAT source 1..11 mol_type protein organism Synthetic construct TVYGGATNKLI 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ALSLYSGAGSYQLT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ILRDRSNQFY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ILRDSRAQKLV 11 AA PAT source 1..11 mol_type protein organism Synthetic construct AVGETGANNLF 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AVALNNNAGNMLT 10 AA PAT source 1..10 mol_type protein organism Synthetic construct AFKAAGNKLT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ATDAGYNQGGKLI 13 AA PAT source 1..13 mol_type protein organism Synthetic construct AASDTGANTGKLT 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASPQGGSEKLV 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSFRALAADTQY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct SAGVGGQETQY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASSVAVSAGTYEQY 10 AA PAT source 1..10 mol_type protein organism synthetic construct ASSQIRETQY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ASTYHGTGY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSSTGLPYGYT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSLRDGYTGELF 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSLADRVNTEAF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct SARGGSYNSPLH 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSLAQGGETQY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASSTTPGTGTETQY 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSAGTSGEYEQY 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSEARRYNEQF 12 AA PAT source 1..12 mol_type protein organism Synthetic construct ASSVAPGSDTQY 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSNRGLGTDTQY 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASSRLAGGMDEQF 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ASSAGNTIY 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ASGDFWGDTLY 14 AA PAT source 1..14 mol_type protein organism Synthetic construct ASSSGGWGGGTEAF 13 AA PAT source 1..13 mol_type protein organism Synthetic construct APQPELPYPQPGS 11 AA PAT source 1..11 mol_type protein organism Synthetic construct QPFPQPELPYP 13 AA PAT source 1..13 mol_type protein organism Synthetic construct SGEGSFQPSQENP 15 AA PAT source 1..15 mol_type protein organism Synthetic construct FELIGILNAAKVPAD 15 AA PAT source 1..15 mol_type protein organism Synthetic construct GELIGTLNAAKVPAD 13 AA PAT source 1..13 mol_type protein organism Synthetic construct PKYVKQNTLKLAT 13 AA PAT source 1..13 mol_type protein organism Synthetic construct QHIRCNIPKRISA 15 AA PAT source 1..15 mol_type protein organism Synthetic construct VHFFKNIVTPRTPGG 16 AA PAT source 1..16 mol_type protein organism Synthetic construct FSWGAEGQRPGFGSGG 12 AA PAT source 1..12 mol_type protein organism Synthetic construct QAFWIDLFETIG 18 AA PAT source 1..18 mol_type protein organism Synthetic construct APSGEGSFQPSQENPQGS 16 AA PAT source 1..16 mol_type protein organism Synthetic construct APSGEGSFQPSQENPQ 11 AA PAT source 1..11 mol_type protein organism Synthetic construct QPQQSFPEQEA 11 AA PAT source 1..11 mol_type protein organism Synthetic construct GPQQSFPEQEA 12 AA PAT source 1..12 mol_type protein organism Synthetic construct RFYKTLRAEQAS 19 AA PAT source 1..19 mol_type protein organism Synthetic construct VEELYLVAGEEGCGGGGSL 13 AA PAT source 1..13 mol_type protein organism Synthetic construct RVSYYGPKTSPVQ 12 AA PAT source 1..12 mol_type protein organism Synthetic construct APFSEQEQPVLG 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ILSGGSNYKLT 11 AA PAT source 1..11 mol_type protein organism Synthetic construct ILSGGCNYKLT 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ASSFGREQY 9 AA PAT source 1..9 mol_type protein organism Synthetic construct ASSFCREQY 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLENFRAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLCNFRAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSKENFKAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLENFAAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLENFLAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLCNFKAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLCNFAAYV 10 AA PAT source 1..10 mol_type protein organism Synthetic construct SSLCNFLAYV 15 AA PAT source 1..15 mol_type protein organism Mus musculus KKDWVSLWKGFSFKK 15 AA PAT source 1..15 mol_type protein organism Synthetic construct KKDWVCLWKGFSFKK 15 AA PAT source 1..15 mol_type protein organism Synthetic construct KKDWVSLWKGFCFKK 15 AA PAT source 1..15 mol_type protein organism Synthetic construct KKDCVSLWKGFSFKK 15 AA PAT source 1..15 mol_type protein organism Synthetic construct KKDWVSLWCGFSFKK 18 AA PAT source 1..18 mol_type protein organism Mus musculus KKENPVVHFFKNIVTPKK 20 DNA PAT source 1..20 mol_type other DNA organism Synthetic construct cgtctgaactggggtaggtg 20 DNA PAT source 1..20 mol_type other DNA organism Synthetic construct ctgaaagcccatggaactgc 30 DNA PAT source 1..30 mol_type other DNA organism Synthetic construct modified_base 28..30 mod_base OTHER note each N base is riboguanosine gaattcacctatcaacgcagagtacatnnn 26 DNA PAT source 1..26 mol_type other DNA organism Synthetic construct aattgaattcacctatcaacgcagag 30 DNA PAT source 1..30 mol_type other DNA organism synthetic construct aattctcgagaagtcggtgaacaggcagag 30 DNA PAT source 1..30 mol_type other DNA organism Synthetic construct aattctcgagtggacctccttgccattcac 20 DNA PAT source 1..20 mol_type other DNA organism synthetic construct cctcacattgccaaaagacg 10 AA PAT source 1..10 mol_type protein organism Synthetic construct ALSSGSWQLI 13 AA PAT source 1..13 mol_type protein organism Synthetic construct ASGEGQGRGERLF 15 AA PAT source 1..15 mol_type protein organism Synthetic construct KKDWVSCWKGFSFKK