WO 258199.060902 US 63/275368 2021-11-03 Janssen Biotech, Inc Jenna D. Goldberg METHODS OF TREATING CANCERS AND ENHANCING EFFICACY OF BCMAXCD3 BISPECIFIC ANTIBODIES 69 184 AA PAT source 1..184 mol_type protein organism Homo sapiens MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR 207 AA PAT source 1..207 mol_type protein organism Homo sapiens MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI 104 AA PAT source 1..104 mol_type protein organism Homo sapiens DGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMD 300 AA PAT source 1..300 mol_type protein organism Homo sapiens MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI 509 AA PAT source 1..509 mol_type protein organism Homo sapiens MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQIFYNASPSTLSATMFIVSILFLIISSVASL 122 AA PAT source 1..122 mol_type protein organism Homo sapiens EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIK 5 AA PAT source 1..5 mol_type protein organism Homo sapiens SFAMS 17 AA PAT source 1..17 mol_type protein organism Homo sapiens AISGSGGGTYYADSVKG 13 AA PAT source 1..13 mol_type protein organism Homo sapiens DKILWFGEPVFDY 11 AA PAT source 1..11 mol_type protein organism Homo sapiens RASQSVSSYLA 7 AA PAT source 1..7 mol_type protein organism Homo sapiens DASNRAT 9 AA PAT source 1..9 mol_type protein organism Homo sapiens QQRSNWPPT 452 AA PAT source 1..452 mol_type protein organism Homo sapiens EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein organism Homo sapiens EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 330 AA PAT source 1..330 mol_type protein organism Homo sapiens ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 327 AA PAT source 1..327 mol_type protein organism Homo sapiens ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 7 AA PAT source 1..7 mol_type protein organism Homo sapiens SGSYFWG 16 AA PAT source 1..16 mol_type protein organism Homo sapiens SIYYSGITYYNPSLKS 11 AA PAT source 1..11 mol_type protein organism Homo sapiens HDGAVAGLFDY 11 AA PAT source 1..11 mol_type protein organism Homo sapiens GGNNIGSKSVH 7 AA PAT source 1..7 mol_type protein organism Homo sapiens DDSDRPS 11 AA PAT source 1..11 mol_type protein organism Homo sapiens QVWDSSSDHVV 121 AA PAT source 1..121 mol_type protein organism Homo sapiens QLQLQESGPGLVKPSETLSLTCTVSGGSISSGSYFWGWIRQPPGKGLEWIGSIYYSGITYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHDGAVAGLFDYWGQGTLVTVSS 111 AA PAT source 1..111 mol_type protein organism Homo sapiens SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQPPGQAPVVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEAVYYCQVWDSSSDHVVFGGGTKLTVLGQP 448 AA PAT source 1..448 mol_type protein organism Homo sapiens QLQLQESGPGLVKPSETLSLTCTVSGGSISSGSYFWGWIRQPPGKGLEWIGSIYYSGITYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARHDGAVAGLFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein organism Homo sapiens SYVLTQPPSVSVAPGQTARITCGGNNIGSKSVHWYQQPPGQAPVVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEAVYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKGDSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 5 AA PAT source 1..5 mol_type protein organism Homo sapiens TYAMN 19 AA PAT source 1..19 mol_type protein organism Homo sapiens RIRSKYNNYATYYAASVKG 14 AA PAT source 1..14 mol_type protein organism Homo sapiens HGNFGNSYVSWFAY 14 AA PAT source 1..14 mol_type protein organism Homo sapiens RSSTGAVTTSNYAN 7 AA PAT source 1..7 mol_type protein organism Homo sapiens GTNKRAP 9 AA PAT source 1..9 mol_type protein organism Homo sapiens ALWYSNLWV 125 AA PAT source 1..125 mol_type protein organism Homo sapiens EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSS 112 AA PAT source 1..112 mol_type protein organism Homo sapiens QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQP 452 AA PAT source 1..452 mol_type protein organism Homo sapiens EVQLVESGGGLVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 215 AA PAT source 1..215 mol_type protein organism Homo sapiens QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 122 AA PAT source 1..122 mol_type protein organism Homo sapiens QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAFSWVRQAPGQGLEWMGRVIPFLGIANSAQKFQGRVTITADKSTSTAYMDLSSLRSEDTAVYYCARDDIAALGPFDYWGQGTLVTVSSAS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYPRTFGQGTKVEIK 122 AA PAT source 1..122 mol_type protein organism Homo sapiens EVQLVQSGAEVKKPGESLKISCKGSGYSFSNYWIGWVRQMPGKGLEWMGIIYPHDSDARYSPSFQGQVTFSADKSISTAYLQWSSLKASDTAMYYCARHVGWGSRYWYFDLWGRGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPGLLIYDASNRASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK 120 AA PAT source 1..120 mol_type protein organism Homo sapiens QVQLVESGGGLVQPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSGISGDPSNTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDLPLVYTGFAYWGQGTLVTVSS 109 AA PAT source 1..109 mol_type protein organism Homo sapiens DIELTQPPSVSVAPGQTARISCSGDNLRHYYVYWYQQKPGQAPVLVIYGDSKRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCQTYTGGASLVFGGGTKLTVLGQ 120 AA PAT source 1..120 mol_type protein organism Homo sapiens QVQLVQSGAEVAKPGTSVKLSCKASGYTFTDYWMQWVKQRPGQGLEWIGTIYPGDGDTGYAQKFQGKATLTADKSSKTVYMHLSSLASEDSAVYYCARGDYYGSNSLDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism Homo sapiens DIVMTQSHLSMSTSLGDPVSITCKASQDVSTVVAWYQQKPGQSPRRLIYSASYRYIGVPDRFTGSGAGTDFTFTISSVQAEDLAVYYCQQHYSPPYTFGGGTKLEIK 7 AA PAT source 1..7 mol_type protein organism Homo sapiens GFTFNSF 6 AA PAT source 1..6 mol_type protein organism Homo sapiens SGSGGG 10 AA PAT source 1..10 mol_type protein organism Homo sapiens GFTFNSFAMS 10 AA PAT source 1..10 mol_type protein organism Homo sapiens AISGSGGGTY 8 AA PAT source 1..8 mol_type protein organism Homo sapiens GFTFNSFA 8 AA PAT source 1..8 mol_type protein organism Homo sapiens ISGSGGGT 15 AA PAT source 1..15 mol_type protein organism Homo sapiens AKDKILWFGEPVFDY 6 AA PAT source 1..6 mol_type protein organism Homo sapiens QSVSSY 9 AA PAT source 1..9 mol_type protein organism Homo sapiens GGSISSGSY 5 AA PAT source 1..5 mol_type protein organism Homo sapiens YYSGI 7 AA PAT source 1..7 mol_type protein organism Homo sapiens GFTFNTY 8 AA PAT source 1..8 mol_type protein organism Homo sapiens RSKYNNYA 12 AA PAT source 1..12 mol_type protein organism Homo sapiens GGSISSGSYFWG 9 AA PAT source 1..9 mol_type protein organism Homo sapiens SIYYSGITY 10 AA PAT source 1..10 mol_type protein organism Homo sapiens GFTFNTYAMN 12 AA PAT source 1..12 mol_type protein organism Homo sapiens RIRSKYNNYATY 10 AA PAT source 1..10 mol_type protein organism Homo sapiens GGSISSGSYF 7 AA PAT source 1..7 mol_type protein organism Homo sapiens IYYSGIT 13 AA PAT source 1..13 mol_type protein organism Homo sapiens ARHDGAVAGLFDY 6 AA PAT source 1..6 mol_type protein organism Homo sapiens NIGSKS 8 AA PAT source 1..8 mol_type protein organism Homo sapiens GFTFNTYA 10 AA PAT source 1..10 mol_type protein organism Homo sapiens IRSKYNNYAT 16 AA PAT source 1..16 mol_type protein organism Homo sapiens ARHGNFGNSYVSWFAY 9 AA PAT source 1..9 mol_type protein organism Homo sapiens TGAVTTSNY