WO 2025100001CPCT CN 2024101420189 2024-02-01 JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. ANTI-CLDN6 ANTIBODY, ANTIBODY-DRUG CONJUGATE THEREOF, AND MEDICAL USE THEREOF 51 220 AA PAT source 1..220 mol_type protein organism Homo sapiens MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV 220 AA PAT source 1..220 mol_type protein organism Macaca fascicularis MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSRGPSHYMARYSTSAPAISRGPSEYPTKNYV 217 AA PAT source 1..217 mol_type protein organism Homo sapiens MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV 217 AA PAT source 1..217 mol_type protein organism Macaca fascicularis MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLLAITGAQCTTCVEDEGAKARIMLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV 220 AA PAT source 1..220 mol_type protein organism Homo sapiens MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAVIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV 219 AA PAT source 1..219 mol_type protein organism Mus musculus MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVTLLIVLLGLLVYLAGAKCTTCVEDRNSKSRLVLISGIIFVISGVLTLIPVCWTAHSIIQDFYNPLVADAQKRELGASLYLGWAASGLLLLGGGLLCCACSSGGTQGPRHYMACYSTSVPHSRGPSEYPTKNYV 217 AA PAT source 1..217 mol_type protein organism Mus musculus MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVLLLLSGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPSHFERPRGPRLGYSIPSRSGASGLDKRDYV 219 AA PAT source 1..219 mol_type protein organism Rattus norvegicus MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVITLLIVLLGLLLYLAGAKCTTCVEDKNSKSRLVLISGVIFVISGVLTLIPICWTAHAIIQDFYNPLVADAQKRELGASLYLGWAASGLLLIGGGLLCCACSSGGTQGPSHYVARYSSPVPHSRGPSEYPSKNYV 217 AA PAT source 1..217 mol_type protein organism Rattus norvegicus MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVVALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVLLLLSGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPSHFERPRGPRLGYSIPSRSGASGLDKRDYV 220 AA PAT source 1..220 mol_type protein organism Homo sapiens MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV 209 AA PAT source 1..209 mol_type protein organism Homo sapiens MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV 119 AA PAT source 1..119 mol_type protein note VH45 organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYVGSWVRQAPGQGLEWMGTISSGVGRTYYPDVVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGDFRYDGFAYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note VL43 organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDSYLAWYQQKPGKAPKLLIYYSTLLVDGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 5 AA PAT source 1..5 mol_type protein note Ab-1-HCDR1 organism synthetic construct SYVGS 17 AA PAT source 1..17 mol_type protein note Ab-1-HCDR2 organism synthetic construct TISSGVGRTYYPDVVKG 10 AA PAT source 1..10 mol_type protein note Ab-1-HCDR3 organism synthetic construct GDFRYDGFAY 11 AA PAT source 1..11 mol_type protein note Ab-1-LCDR1 organism synthetic construct RASYNIDSYLA 7 AA PAT source 1..7 mol_type protein note Ab-1-LCDR2 organism synthetic construct YSTLLVD 9 AA PAT source 1..9 mol_type protein note Ab-1-LCDR3 organism synthetic construct QHYYSIPYT 330 AA PAT source 1..330 mol_type protein note hIgG1-LALA organism synthetic construct ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein note hu-kappa organism synthetic construct RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT source 1..449 mol_type protein note Ab-1-HC organism synthetic construct QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYVGSWVRQAPGQGLEWMGTISSGVGRTYYPDVVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGDFRYDGFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein note Ab-1-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDSYLAWYQQKPGKAPKLLIYYSTLLVDGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 7 AA PAT source 1..7 mol_type protein note LCDR2-D56E organism synthetic construct YSTLLVE 11 AA PAT source 1..11 mol_type protein note LCDR1-S31R organism synthetic construct RASYNIDRYLA 11 AA PAT source 1..11 mol_type protein note LCDR1-S31Q organism synthetic construct RASYNIDQYLA 11 AA PAT source 1..11 mol_type protein note LCDR1-S31I organism synthetic construct RASYNIDIYLA 11 AA PAT source 1..11 mol_type protein note LCDR1-S31L organism synthetic construct RASYNIDLYLA 11 AA PAT source 1..11 mol_type protein note LCDR1-S31V organism synthetic construct RASYNIDVYLA 107 AA PAT source 1..107 mol_type protein note VL43+D56E organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDSYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein note VL43+D56E+S31R organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDRYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein note VL43+D56E+S31Q organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDQYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein note VL43+D56E+S31I organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDIYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein note VL43+D56E+S31L organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDLYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein note VL43+D56E+S31V organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDVYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIK 214 AA PAT source 1..214 mol_type protein note Ab-2-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDSYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Ab-3-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDRYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Ab-4-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDQYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Ab-5-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDIYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Ab-6-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDLYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 214 AA PAT source 1..214 mol_type protein note Ab-7-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASYNIDVYLAWYQQKPGKAPKLLIYYSTLLVEGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQHYYSIPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 448 AA PAT source 1..448 mol_type protein note Isotype-HC organism synthetic construct QVQLVQSGAEVKKPGASVKVSCKASGYTFTNSWIGWFRQAPGQGLEWIGDIYPGGGYTNYNEIFKGKATMTADTSTNTAYMELSSLRSEDTAVYYCSRGIPGYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 220 AA PAT source 1..220 mol_type protein note Isotype-LC organism synthetic construct DIQMTQSPSSLSASVGDRVTMSCKSSQSLLNSGDQKNYLTWYQQKPGKAPKLLIYWASTGESGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQNDYSYPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 4 AA PAT source 1..4 mol_type protein note L3 organism synthetic construct GGFG 4 AA PAT source 1..4 mol_type protein note linker organism synthetic construct GGVA 4 AA PAT source 1..4 mol_type protein organism synthetic construct SITE 2 note D-Glycine GGVA 4 AA PAT source 1..4 mol_type protein note linker organism synthetic construct GGPI 000 4 AA PAT source 1..4 mol_type protein note linker organism synthetic construct GGVK 4 AA PAT source 1..4 mol_type protein note linker organism synthetic construct SITE 2 note D-Gly GGPI 4 AA PAT source 1..4 mol_type protein note linker organism synthetic construct GGPL