HER2 ADC CN 202310066299.X 2023-01-19 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Jiangsu Hengrui Pharmaceuticals Co., Ltd. ANTI-HER2 ANTIBODY-DRUG CONJUGATE FOR TREATING BREAST CANCER 10 214 AA PAT source 1..214 mol_type protein note Light chain organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 450 AA PAT source 1..450 mol_type protein note Heavy chain organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 5 AA PAT source 1..5 mol_type protein note HCDR1 organism synthetic construct DTYIH 17 AA PAT source 1..17 mol_type protein note HCDR2 organism synthetic construct RIYPTNGYTRYADSVKG 11 AA PAT source 1..11 mol_type protein note HCDR3 organism synthetic construct WGGDGFYAMDY 11 AA PAT source 1..11 mol_type protein note LCDR1 organism synthetic construct RASQDVNTAVA 7 AA PAT source 1..7 mol_type protein note LCDR2 organism synthetic construct SASFLYS 9 AA PAT source 1..9 mol_type protein note LCDR3 organism synthetic construct QQHYTTPPT 120 AA PAT source 1..120 mol_type protein note Heavy chain variable region organism synthetic construct EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein note Light chain variable region organism synthetic construct DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK